Imaging of Oncolytic Virus Gene Expression

Rojas, Juan J.; Thorne, Steve H.

doi:10.1016/b978-0-12-394295-1.00031-7

Cited by 1 publication

(1 citation statement)

References 79 publications

(62 reference statements)

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“…In contrast to fluorescence-based imaging, BLI does not require laser excitation, thus avoiding phototoxicity and background interference. The main disadvantage of in vivo BLI is a poor spatial resolution of 1–10 mm and a limited imaging depth of 1–2 cm due to the light scattering of tissues ( 24 , 31 ). The imaging photons quickly diffuse at depths deeper than 0.5 mm, and the corresponding resolution of images degrades severely at deeper depths.…”

Section: Optical Imaging Techniquesmentioning

confidence: 99%

Discovering Macrophage Functions Using In Vivo Optical Imaging Techniques

Liu

2018

Front. Immunol.

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Macrophages are an important component of host defense and inflammation and play a pivotal role in immune regulation, tissue remodeling, and metabolic regulation. Since macrophages are ubiquitous in human bodies and have versatile physiological functions, they are involved in virtually every disease, including cancer, diabetes, multiple sclerosis, and atherosclerosis. Molecular biological and histological methods have provided critical information on macrophage biology. However, many in vivo dynamic behaviors of macrophages are poorly understood and yet to be discovered. A better understanding of macrophage functions and dynamics in pathogenesis will open new opportunities for better diagnosis, prognostic assessment, and therapeutic intervention. In this article, we will review the advances in macrophage tracking and analysis with in vivo optical imaging in the context of different diseases. Moreover, this review will cover the challenges and solutions for optical imaging techniques during macrophage intravital imaging.

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Section: Optical Imaging Techniquesmentioning

confidence: 99%

Discovering Macrophage Functions Using In Vivo Optical Imaging Techniques

Liu

2018

Front. Immunol.

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Imaging of Oncolytic Virus Gene Expression

Cited by 1 publication

References 79 publications

Discovering Macrophage Functions Using In Vivo Optical Imaging Techniques

Discovering Macrophage Functions Using In Vivo Optical Imaging Techniques

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