Imaging of neural conduction block by neuromagnetic recording

Fukuoka, Yuko; Komori, Hiromichi; Kawabata, Shigenori; Ohkubo, Harunobu; Shinomiya, Kenichi; Terasaki, Omi

doi:10.1016/s1388-2457(02)00345-0

Cited by 24 publications

(9 citation statements)

References 20 publications

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“…Because the perpendicular inflow currents correspond to volume currents flowing into depolarization sites, attenuation of the perpendicular currents at C4/5 indicates conduction block around C4/5. As we previously reported, the trailing component also disappeared when the perpendicular inflow currents disappeared 41, 42 , because it too was generated by the depolarization site.…”

Section: Discussionsupporting

confidence: 69%

“…To date, we have reported neuromagnetic fields in animals using MSG, propagation and conduction block of spinal cord evoked magnetic fields (SCEFs) 37–39 , magnetic fields evoked by synaptic activity in the lumbar spinal cord of the rabbit 40 , and the detailed characteristics of action currents and magnetic fields at the site of conduction block in isolated nerves 41, 42 . In addition, we have recorded neuromagnetic fields from the lumbar canal of human subjects 43 .…”

Section: Introductionmentioning

confidence: 99%

“…In our early studies, we made assumptions about action currents and volume conductors for source localization 41, 42 that proved useful for relatively simple systems, such as an isolated peripheral nerve, but were not satisfactory when applied to the spinal cord. In the present study, we used a spatial filter called a recursive null-steering (RENS) beamformer 47, 48 that does not assume any volume conductor.…”

Section: Introductionmentioning

confidence: 99%

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Magnetospinography visualizes electrophysiological activity in the cervical spinal cord

Sumiya

Kawabata

Hoshino

et al. 2017

Sci Rep

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Diagnosis of nervous system disease is greatly aided by functional assessments and imaging techniques that localize neural activity abnormalities. Electrophysiological methods are helpful but often insufficient to locate neural lesions precisely. One proposed noninvasive alternative is magnetoneurography (MNG); we have developed MNG of the spinal cord (magnetospinography, MSG). Using a 120-channel superconducting quantum interference device biomagnetometer system in a magnetically shielded room, cervical spinal cord evoked magnetic fields (SCEFs) were recorded after stimulation of the lower thoracic cord in healthy subjects and a patient with cervical spondylotic myelopathy and after median nerve stimulation in healthy subjects. Electrophysiological activities in the spinal cord were reconstructed from SCEFs and visualized by a spatial filter, a recursive null-steering beamformer. Here, we show for the first time that MSG with high spatial and temporal resolution can be used to map electrophysiological activities in the cervical spinal cord and spinal nerve.

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Section: Discussionsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Magnetospinography visualizes electrophysiological activity in the cervical spinal cord

Sumiya

Kawabata

Hoshino

et al. 2017

Sci Rep

Self Cite

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“…We had reported that spinal cord evoked magnetic fields (SCEFs) after spinal cord stimulation could be detected over the skin surface of cats and we were able to identify the conduction block at the site of spinal cord transection [1,2].…”

Section: Introductionmentioning

confidence: 98%

Segmental spinal cord evoked magnetic fields by peripheral nerve stimulation

Tomizawa

Komori

Kawabata

et al. 2005

International Congress Series

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“…We studied magnetic fields of peripheral nerves and spinal cord evoked magnetic fields (SCEFs) in animals [1][2][3][4], and demonstrated that the conductive spinal cord activity could be visualized by magnetic contour maps. In this study, we recorded three-dimensional SCEFs of the cervical spine of rabbits at the skin surface, and evaluated the usefulness of three-dimensional SCEFs in the examination of spinal cord function.…”

Section: Introductionmentioning

confidence: 99%