Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose: correlation with CT.

Abstract

These preliminary data indicate excellent accuracy for FDG-PET imaging of thoracicoabdominal lymphoma. All grades of NHL were successfully imaged with FDG-PET. PET appears to be a useful method for imaging lymphoma.

Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose

“…Results were different in patients with low-grade NHL: Concordant results were observed in 9/14 patients by clinical examination and in 7/13 patients by CT. More sites were detected by PET than by clinical examination in two patients and more were detected by PET than by CT in one patient, while more sites were detected by clinical examination in three patients and by CT in five patients. These results differ from other reports concerning low-grade NHL [185,186]. One possible reason is that other reports have concentrated on a single area for comparison while this study involved whole-body scans.…”

“…Several reports have shown the feasibility of imaging lymphomas using FDG [183][184][185][186][187][188][189][190]. This approach is of particular interest as metabolic imaging does not face the difficulties of structural imaging modalities in defining the presence and extent of lymphomatous turnouts.…”

“…space occupation) or enlargement (e.g. nodal) of anatomical structure to suggest tumour, and abnormal findings lack specificity [185].…”

“…Newman et al [185] compared FDG PET and CT in 16 patients with mixed lymphoma cases. PET (not using the whole-body technique) identified 54 abnormalities in 13 patients compared with 49 by CT.…”

Comparison of fluorine‐18 fluorodeoxyglucose positron emission tomography and Ga‐67 scintigraphy in evaluation of lymphoma

“…Preliminary data suggest that FDG-PET is a useful tool to stage and monitor lymphoma. [13][14][15][16][17][18][19][20][21][22][23] However, there has been scarce data comparing FDG-PET and Ga-67 scintigraphy; thus, their comparative value is still conjectural. 13,24,25 Accordingly, we prospectively compared the accuracy of whole-body FDG-PET and Ga-67 scintigraphy to identify disease sites in HD and non-Hodgkin lymphoma (NHL; intermediate grade and high grade) at initial staging or recurrence before chemotherapy.…”