Imaging of Intrathoracic Paragangliomas

Ocazionez, Daniel; Shroff, Girish S.; Vargas, Daniel; Dicks, Demetrius; Chaturvedi, Abhishek; Nachiappan, Arun C.; Murillo, Horacio; Baxi, Ameya; Restrepo, Carlos S.

doi:10.1053/j.sult.2017.07.004

Cited by 8 publications

(12 citation statements)

References 39 publications

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“…Paragangliomas arising in the anterior or middle mediastinum are clinically and histologically similar to their cervical counterparts. In contrast, paragangliomas of the posterior mediastinum are similar to their retroperitoneal counterparts with possible catecholamine release [50]. It is important to differentiate paragangliomas (cytokeratin-negative) from thymic carcinoids (cytokeratin-positive), since familial paragangliomas may be associated with germline mutations such as succinate dehydrogenase gene mutations and patients may benefit from genetic testing [51].…”

Section: Paragangliomasmentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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The diagnosis of a mediastinal mass may be challenging for clinicians, since lesions arising within the mediastinum include a variety of disease entities, frequently requiring a multidisciplinary approach. Age and sex represent important information, which need to be integrated with imaging and laboratory findings. In addition, the location of the mediastinal lesion is fundamental; indeed, we propose to illustrate mediastinal diseases based on the compartment of origin. We consider that this structured approach may serve as hint to the diagnostic modalities and management of mediastinal diseases. In this review, we present primary mediastinal tumours in the evolving context of new diagnostic and therapeutic tools, with recently described entities, based on our own experience with >900 cases encountered in the past 10 years.

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Section: Paragangliomasmentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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“…Twenty to 30% of paragangliomas are hereditary and present in one of the family forms: multiple paraganglioma disease and Von Hippel-Lindau disease. In these familial forms, the paragangliomas are often present on several sites and are recurrent [3][4][5][6].…”

Section: Paragangliomas As a Rare Tumormentioning

confidence: 99%

“…Internal hemorrhage and cystic components contribute to the heterogeneous MRI appearance of these tumors. Additional use of opposed phase imaging can be helpful as paragangliomas do not exhibit dropout of signal on opposed phase imaging, but adenomas do [1,6,10,13,18].…”

Section: Pre-treatment Assessmentmentioning

confidence: 99%

“…These examinations are generally based on the radiation emitted by a radioactive isotope which is concentrated by the tumor and allows its detection. Firstly, the scintigraphy of the whole body by 123 I-MIBG (Meta Iodo Benzyl Guanidine) or the Scintigraphy of the Somatostatin Receptors (SRS), also called Octreoscan ® , provide details on the tumor(s), explore the whole body, and participate in the extension assessment [2,6,8,12]. In addition to the interest for the detection of tumors, these scintigraphy examinations assess the importance of the tumor concentration of tracers and the interest of their therapeutic use.…”

Section: Pre-treatment Assessmentmentioning

confidence: 99%

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Resection of a Giant Middel Mediastinum Paraganglioma by Clamshell Incision without Cardiopulmonary Bypass

2023

Ann Case Report

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Paraganglioma is a tumor developed from paraganglia, which are groups of neuroendocrine cells located along the vascular and nerve axes of the head and neck and along the spine. These tumors are benign and still localized in more than 80% of cases.Middle mediastinal paragangliomas represent less than 1% of mediastinal tumors and grow from the superior or middle mediastinal autonomic ganglion; they mostly are non-functional and are found in older patients. The often large volume and complex location of these tumors make their surgical resection challenging forcing the surgical team to resort to cardiopulmonary bypass and practice transfection of the aortic artery.We successfully operated an 80-year-old patient by clamshell incision without bypass or arterial procedure.

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“…Intrathoracic paragangliomas account for <10% of all paragangliomas and clinically significant intrathoracic paragangliomas are found most commonly in the mediastinum (48). Paragangliomas can also be found in the lungs, trachea, heart, pericardium, and esophagus (49). Anterior and middle mediastinal paragangliomas (Fig 7B) usually arise from aortic body chemoreceptors at the aorticopulmonary region whereas posterior mediastinal paragangliomas (Fig 7C) arise from the paravertebral sympathetic chain (47).…”

Section: Malignancies and Conditions Associated With Malignancy Paragmentioning

confidence: 99%

It's Not All in Your Head: Thoracic Manifestations of Neurologic Diseases and Disorders

Shroff

Ocazionez

et al. 2022

Academic Radiology

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Myriad conditions may affect both the neurologic system and the thorax, while other diseases primarily affecting the thorax may manifest with neurologic abnormalities. Correlation of signs, symptoms, and imaging findings in the neurological system with those in the thorax can help diagnose certain conditions and/or guide further diagnostic work-up and treatment. We will review and illustrate the imaging appearance of several systemic/neurological diseases with thoracic manifestations as well as discuss conditions in the thorax that can lead to neurologic symptoms.

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Imaging of Intrathoracic Paragangliomas

Cited by 8 publications

References 39 publications

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Resection of a Giant Middel Mediastinum Paraganglioma by Clamshell Incision without Cardiopulmonary Bypass

It's Not All in Your Head: Thoracic Manifestations of Neurologic Diseases and Disorders

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