Imaging of Huntington's disease

Negi, R. S.; Manchanda, K.L.; Sanga, Sunil

doi:10.1016/j.mjafi.2012.08.002

Cited by 9 publications

(6 citation statements)

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“…There will be atrophy of the caudate nucleus, leading to the absence of the typical bulge of these structures on the frontal horns, causing localized enlargement. Caudate nucleus atrophy and increased signal intensity on T2-weighted imaging in the basal ganglia and thalamus are common findings in HD [ 11 , 12 ]. Later in the disease progression, ventriculomegaly due to parenchymal atrophy becomes apparent.…”

Section: Discussionmentioning

confidence: 99%

Huntington's Disease: A Report of an Interesting Case and Literature Review

Sharma,

Aram,

Polaka

et al. 2024

Cureus

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Huntington's disease (HD), referred to as Huntington's chorea, is an infrequent neurodegenerative ailment with an autosomal-dominant inheritance pattern characterized by the progressive deterioration of GABAergic neurons in the basal ganglia. Other ones include subcortical-type dementia, behavioral abnormalities, midlife psychosis, and gradual inadvertent choreoathetosis movements. HD is characterized by atrophy of the dorsal striatum (caudate nucleus and putamen) with concurrent expansion of the frontal horns of the lateral ventricles on imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). A molecular study validates the diagnosis of HD by identifying the disorder's hallmark amplified CAG triplet. Currently, there is no cure for HD, and treatment focuses on providing supportive care and managing the symptoms. Multidisciplinary approaches involving healthcare professionals, neurologists, and psychiatrists are crucial for comprehensive management. Medications are used to alleviate motor symptoms and manage psychiatric manifestations. Physical and occupational therapies help maintain functional abilities and improve quality of life. Genetic counseling and psychosocial support are essential for patients and their families. An additional crucial objective entails advancing more precise and dependable techniques for the timely identification and assessment of HD. Timely interventions and improved symptom management are made possible by early diagnosis. Based on clinical and imaging findings, we present a case of HD in a 62-year-old female.

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Section: Discussionmentioning

confidence: 99%

Huntington's Disease: A Report of an Interesting Case and Literature Review

Sharma,

Aram,

Polaka

et al. 2024

Cureus

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“…Gambaran signal hiperintens pada striatum menunjukkan hilangnya neuron dan glial di mana penumpukan besi memberikan gambaran signal hipointens. 16 Pada bentuk juvenil, putamen juga mengalami atrofi dan memberikan peningkatan signal T2. 15 Pada beberapa kasus tertentu ganglia basalis dapat menunjukkan penurunan signal T2 dan meningkat pada susceptibility weighted imaging (SWI) sesuai dengan deposisi besi.…”

Section: Temuan Mriunclassified

“…15 Pada studi volumetrik penurunan volume pada otak dapat ditemukan pada struktur striatum, talamus dan hipokampus. 16 Gambar 2. MRI Kepala T1 dengan potongan aksial .Atrofi nukleus kaudatus bilateral pada penderita Huntington dengan lebar FH terukur (33.5mm) (2), lebar inner Gambar 4.…”

Section: Temuan Mriunclassified

“…MRI aksial T2-weighted menunjukkan atrofi bilateral kaput nukleus kaudatus dengan pembesaran kornu anterior ventrikel lateral yang memberikan konfigurasi "box-like". 16 fMRI fMRI memberikan pendekatan neuroradiologi untuk menelaah aktifitas neuron dengan mengukur adanya respon hemodinamik dari aktivasi neuron. Pada penyakit Huntington tampak adanya penurunan aktivasi di beberapa regio seperti sub-kortikal dan kortikal, disertai dengan peningkatan aktivasi di beberapa regio lainnya.…”

Section: Temuan Mriunclassified

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Penyakit Pre-Huntington dan Huntington

Tjan

Widhiasih²,

Sitanggang³

2016

J Rad Idn

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“…MRI examination of the patient's brain did not reveal pathology typical of Huntington's disease ( Fig. 1) [1,2]. Putamen and Caudate are the primary sites to be affected for the structural changes in Huntington's disease.…”

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confidence: 98%