Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli–Leydig cell tumors and Leydig cell tumors

Демидов, В Н; Lipatenkova, J; Vikhareva, O; Holsbeke, C. Van; Timmerman, Dirk; Valentin, Lil

doi:10.1002/uog.5227

Cited by 75 publications

(39 citation statements)

References 5 publications

(11 reference statements)

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“…9 Compared with the cystic appearance of a mature teratoma, these tumors are mostly solid. If a cystic component is present, the fluid component is anechoic 10 and lacks the typical findings of a mature teratoma, such as echogenic masses with acoustic shadowing or hyperechoic lines and dots, as was seen in our case.…”

Section: Discussionsupporting

confidence: 48%

Testosterone‐Secreting Mature Ovarian Teratoma Causing Severe Virilization in an Adolescent

Rotenberg

Shahabi

Dar

2009

J of Ultrasound Medicine

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A 15-year-old nulligravida came to our clinic with hirsutism, acne, voice changes, menometrorrhagia, clitoromegaly, and an abdominal mass. She had her menarche at 12 years of age and, since then, had had regular periods. She was never sexually active. Two years earlier, she was hospitalized for several months with seizures and a mental status change that was diagnosed as Mycoplasma encephalitis. A few months after her discharge, hirsutism and aggressive behavioral changes developed, which were attributed to her encephalitis. This was followed by development of an adult masculine voice and irregular periods. Her vocal cords were visualized and were found to be normal. The patient was referred to our clinic after she was noted to have increased abdominal girth, and a large cystic mass was palpated in the left adnexa. Case ReportSonographic and Color Doppler Characteristics yperandrogenism, associated with hirsutism in adolescent girls and premenopausal women, is a common cause of irregular menses; it affects 5% to 7% of adult women.1 The most common etiology of androgen disorders is polycystic ovary syndrome, occurring in 70% to 80% of cases. 1,2Androgen-secreting neoplasms are rare and account for less than 0.3% of patients with hirsutism.2 These neoplasms should be suspected when the onset of androgenic symptoms is rapid and sudden. We report a rare case of an adolescent girl with severe virilism and behavioral changes associated with a testosterone-secreting mature ovarian teratoma.H

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Section: Discussionsupporting

confidence: 48%

Testosterone‐Secreting Mature Ovarian Teratoma Causing Severe Virilization in an Adolescent

Rotenberg

Shahabi

Dar

2009

J of Ultrasound Medicine

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“…On ultrasound, Sertoli-Leydig cell tumors appear to be heterogeneous vascularized masses with solid zones; in the pure Sertoli cell forms, they are multilocular, associated with anechoic liquid zones. Their size can achieve up to about 20 cm [8]. In our case, the patient neglected the enlargement of the abdomen over the years, the tumor reached 22 cm in the major axis.…”

Section: Diagnosismentioning

confidence: 57%

Inoperable Ovarian Sertoli Cell Tumor in an Elderly Patient, Case Report and Review of Literature

Bedoudou¹,

Aboueljaoud²,

Mai³

et al. 2017

J Cancer Sci Ther

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Ovarian sex cord-stromal tumors are a group of rare neoplasms, considered to be low-grade malignant tumors. The Sertoli-Leydig cell tumors subgroup occur mostly in young patients and reveals itself with virilization symptoms. Here we report a rare case of a voluminous well differentiated tumor in a 75-year-old patient with no sign of secretory effects. The radical treatment was impossible, and a palliative chemotherapy was indicated.

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“…It is difficult to predict the long-term clinical nature of the disease, particularly in terms of different histology. The prognosis depends on tumor staging, differentiation, presence of heterologous elements, mitotic index, and tumor dissemination before, or during surgery (11). Most of the children with SLCT present with intermediate-grade tumor (2).…”

Section: Discussionmentioning

confidence: 99%

Severe virilization in adolescent girl with Sertoli-Leydig cell tumor – case report and review of the literature

Krnić

Putarek

Kubat

et al. 2018

CEJP

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Objective -The aim was to report a case of a 17-year-old girl with marked virilization and secondary amenorrhea due to androgen producing Sertoli-Leydig cell tumor (SLCT). We also provided a brief review of the literature with insight into clinical picture, pathological features and treatment of patients with this rare tumor. Case report − We present a 17-year-old girl with SLCT, who developed clinical symptoms of severe virilization. The tumor secreted testosterone and alpha fetoprotein (AFP). The imaging revealed tumor of the right ovary which histologically corresponded to intermediate-grade SLCT with low mitotic rate. Furthermore, it was stage IA according to International Federation of Gynecology and Obstetrics. Laparoscopic right salpingo-oophorectomy was preformed, resulting in regression of virilization symptoms and normalization of serum testosterone and AFP levels. Conclusion − Due to rarity of SLCT in children and adolescents, gathering information from available case reports is necessary to establish guidelines regarding optimal management, including type of surgery and adjuvant chemotherapy. New knowledge regarding related diseases in SLCT survivors emphasize the need for long-term follow up of these patients.

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Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli–Leydig cell tumors and Leydig cell tumors

Abstract: Objective To describe the clinical history and ultrasound findings in women with ovarian Sertoli cell, Sertoli-Leydig cell and Leydig cell tumors. Methods

Cited by 75 publications

References 5 publications

Testosterone‐Secreting Mature Ovarian Teratoma Causing Severe Virilization in an Adolescent

Testosterone‐Secreting Mature Ovarian Teratoma Causing Severe Virilization in an Adolescent

Inoperable Ovarian Sertoli Cell Tumor in an Elderly Patient, Case Report and Review of Literature

Severe virilization in adolescent girl with Sertoli-Leydig cell tumor – case report and review of the literature

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