Imaging of giant cell arteritis – recent advances

Owen, Claire; Yates, Max; Liew, David; Poon, Aurora; Keen, Helen; Hill, Catherine; McDermott, Michael

doi:10.1016/j.berh.2023.101827

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…The “ideal” way to monitor disease activity using this plethora of imaging modalities is consistently being explored given the common discordance between imaging findings and typical disease activity measures. 37…”

Section: Pro—ultrasound Can Replace Temporal Artery Biopsy For Diagno...mentioning

confidence: 99%

“…The "ideal" way to monitor disease activity using this plethora of imaging modalities is consistently being explored given the common discordance between imaging findings and typical disease activity measures. 37 In 2023, the European Alliance of Associations for Rheumatology (EULAR), updated their 2018 recommendations for the use of imaging modalities in primary large vessel vasculitis including GCA. The recommendations were updated based on evidence and expert consensus.…”

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confidence: 99%

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Can Ultrasound Replace Temporal Artery Biopsy for Diagnosing Giant Cell Arteritis?

Hamann,

Ing,

Lee

et al. 2024

Journal of Neuro-Ophthalmology

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Giant cell arteritis (GCA) is one of the most feared diagnoses for neuro ophthalmologists, eye care providers in general, rheumatologists, and primary care providers. Treatment for GCA typically requires a long duration of immunosuppressive therapy, which carries the risk of shortterm and long-term side effects. These side effects can be particularly debilitating in the affected elderly population. Therefore, the goal of diagnostic testing for GCA is to secure the diagnosis with as high a level of confidence as possible, to justify the potential risks of long-term treatment. In the past, temporal artery biopsy (TAB) has been the gold standard for diagnosis. More recently, temporal artery ultrasonography (TAU) has emerged as a potential alternative, with more convenience and lower cost. Two authors debate whether temporal artery ultrasound can replace temporal artery biopsy.

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Section: Pro—ultrasound Can Replace Temporal Artery Biopsy For Diagno...mentioning

confidence: 99%

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confidence: 99%

Can Ultrasound Replace Temporal Artery Biopsy for Diagnosing Giant Cell Arteritis?

Hamann,

Ing,

Lee

et al. 2024

Journal of Neuro-Ophthalmology

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Treat-to-target in polymyalgia rheumatica and giant cell arteritis: an impending, multifaceted challenge

Liew,

Owen

2024

Rheumatology

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Association between diabetes mellitus and giant cell arteritis: a bidirectional 2-sample mendelian randomization study

Chen,

Zeng,

et al. 2024

Egypt J Med Hum Genet

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Objective Recent studies have indicated a potential association between giant cell arteritis (GCA) and diabetes mellitus, encompassing both type 1 diabetes (T1D) and type 2 diabetes (T2D). However, the exact nature of this relationship requires further investigation to be fully elucidated. Methods Genetic links between T1D/T2D and GCA were explored using data from genome-wide association studies available to the public, focusing on populations of European ancestry. We applied a bidirectional mendelian randomization (MR) approach to assess the potential association between these diseases. Confirmatory analyses, including additional datasets and a comprehensive meta-analysis, were utilized. The inverse-variance-weighted (IVW) method was applied to pinpoint heterogeneity and pleiotropy, while subsequent sensitivity analyses aimed to trace the origins of any heterogeneity. Results Initial analysis demonstrated a correlation between T1D and an elevated likelihood of developing GCA (IVW odds ratio = 1.33, with a 95% confidence interval of 1.22–1.46, and a P-value of 9.42E−10). The causal association was verified through four validation datasets and meta-analysis (all P-value < 0.001). However, the reverse MR analysis was unable to detect any genetic basis for the increased risk of T1D due to GCA. Furthermore, we could not establish any causal links between T2D and GCA. Conclusion T1D patients may have a higher risk of developing GCA, whereas an inverse causal relationship was not evident. Furthermore, no causal relationship was detected between T2D and GCA. These insights shed light on the possible pathological mechanisms underlying GCA and may influence the future clinical handling of both T1D and GCA.

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Imaging of giant cell arteritis – recent advances

Cited by 3 publications

References 85 publications

Can Ultrasound Replace Temporal Artery Biopsy for Diagnosing Giant Cell Arteritis?

Can Ultrasound Replace Temporal Artery Biopsy for Diagnosing Giant Cell Arteritis?

Treat-to-target in polymyalgia rheumatica and giant cell arteritis: an impending, multifaceted challenge

Association between diabetes mellitus and giant cell arteritis: a bidirectional 2-sample mendelian randomization study

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