Imaging of Cu, Zn, Pb and U in human brain tumor resections by laser ablation inductively coupled plasma mass spectrometry

Zoriy, Miroslav; Dehnhardt, Markus; Reifenberger, Guido; Zilles, Karl; Becker, J. Sabine

doi:10.1016/j.ijms.2006.06.005

Cited by 81 publications

(84 citation statements)

References 23 publications

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“…34 The Mn tumour levels in that study varied 10-fold between two patients, in line with the large variation that we observed between tumours of glioblastoma patients. No information was available on the third patient.…”

Section: Controls and Standards From Normal Tissuessupporting

confidence: 83%

Distributions of manganese in diverse human cancers provide insights into tumour radioresistance

Doble

Miklos²

2018

Metallomics

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Section: Controls and Standards From Normal Tissuessupporting

confidence: 83%

Distributions of manganese in diverse human cancers provide insights into tumour radioresistance

Doble

Miklos²

2018

Metallomics

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“…Maps can then be constructed of both metals and non-metals essential to physiology. Recently, elemental bioimaging has been applied to human glioblastomas 16 , labelled β-amyloid-bound antibodies in Alzheimer's disease 17 , implanted tumour cells 18 and Cu, Zn and Pt in cis-platin dosed mice 19 .…”

Section: Introductionmentioning

confidence: 99%

Elemental bio-imaging of melanoma in lymph node biopsies

Hare

Burger

Austin

et al. 2009

Analyst

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The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging of 31 P within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative 31 P concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the 31 P/ 34 S ratio. 31 P/ 66 Zn ratio images showed a decreasing ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue.

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“…The main field of application for LA-ICP-MS is in geological research, including geochronology, isotope variation in nature, and geochemistry [13][14][15][16][17]. LA-ICP-MS is established as a powerful and sensitive analytical technique in material and environmental research, in particular, for the investigation of highpurity materials, superhard materials of layered systems, or for monitoring of long-lived radionuclides in contaminated soil samples [18,19].…”

mentioning

confidence: 99%

“…LA-ICP-MS is established as a powerful and sensitive analytical technique in material and environmental research, in particular, for the investigation of highpurity materials, superhard materials of layered systems, or for monitoring of long-lived radionuclides in contaminated soil samples [18,19]. As a new application field LA-ICP-MS is employed in biological and medical research [20,21] for image (mapping) of the lateral element distribution in an entire sample [13,14,[22][23][24][25][26]. As an example, imaging LA-ICP-MS techniques were developed [27] for quantitative mapping of selected elements (P, S, Fe, Cu, Zn, and C) in thin sections of brain samples, infected and noninfected with tumor (thickness 20 m).…”

mentioning

confidence: 99%

Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

Zoriy¹,

Mayer

Becker³

2009

J. Am. Soc. Mass Spectrom.

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An analytical mass spectrometric method for the elemental analysis of nano-bioelectronic devices involved in bioengineering research was developed and applied for measurements of selected metals (Au, Ti, Pt, Cr, etc.) on interdigitated electrode array chips (IDA-chip). An imaging laser ablation inductively coupled plasma mass spectrometric (LA-ICP-MS) procedure was used to map the elements of interest on the surface of the analyzed sample. The obtained images of metals were in a good agreement and corresponded to the micro-and nanofabricated metal electrode pattern. For the analysis at nanometer resolution scale a NF-LA-ICP-MS (NF-near-field) procedure was applied, which utilize thin Ag needle to enhance laser beam energy and improve spatial resolution of the method. The results show a ϳ100ϫ enhancement of analyte signal, when the needle was positioned in the "near-field region" to the sample surface and the laser shot was performed. In addition, mass spectrometric studies of reproducibly for five separated NF-LA shots in different places of analyzed sample yielded an RSD of the measurement of 16%. io engineering (or biological engineering), including biomedical engineering and nanobiotechnology, is a new, challenging, and rapidly growing high-tech research field [1,2]. The use of biomolecules as the building blocks of higher-level functional devices will lead to applications that range from the integration of biomaterials with electronics in recognition or sensing devices [3]. Bioelectronics research also exploits to use biomolecules to perform the electronic functions that semiconductor devices currently perform, thereby offering the potential to increase integration in combination with additional functionality at the nanometer level. However, the integration of biomolecules or even whole cells with inorganic devices brings several challenges about as there are, for instance, operation of the electronic components under physiological conditions, electrically, biochemically as well as size-adapted bioinorganic interfaces, and biocompatibility of the electronic devices. The implementation of these challenges and the realization of functional bioelectronic junctions require interdisciplinary research, including microengineering, biotechnology, surface chemistry, and analytical research.The fabrication of bioelectronic component on the basis of silicon microtechnology facilitates high integration densities, high spatial resolution, combining signal recording and transducing in one device at relatively low production costs. To build and assemble bioinorganic electronic components with well defined and optimized features, it usually requires control over impurities of trace levels contaminations, which can influence the physical, electrical, magnetic, and chemical properties of thin layered systems. In particular, the biocompatibility of device can be strongly affected by organic and inorganic impurities introduced during the fabrication processes. Therefore, powerful and sensitive trace analytical techniques are ne...

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Imaging of Cu, Zn, Pb and U in human brain tumor resections by laser ablation inductively coupled plasma mass spectrometry

Cited by 81 publications

References 23 publications

Distributions of manganese in diverse human cancers provide insights into tumour radioresistance

Distributions of manganese in diverse human cancers provide insights into tumour radioresistance

Elemental bio-imaging of melanoma in lymph node biopsies

Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

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