Imaging of corticobasal degeneration syndrome

Abstract

CBDS might be unique in showing hyperintensity in the subcortical white matter in the rolandic region on FLAIR images with asymmetric atrophy predominantly contralateral to the side clinically more severely affected. Asymmetric atrophy in the cerebral peduncle without signal abnormalities was also characteristic of CBDS. Atrophy in the midbrain tegmentum was also seen in patients with CBDS.

Imaging-Pathologic Correlation in Corticobasal Degeneration

“…The localization of SCWM abnormalities, though different from those in previous reports, 1,15 was prominent in the present study. In CBD, Tokumaru et al, 15 Doi et al, 16 and Koyama et al 1 described predominantly unilateral SCWM abnormalities on T2-weighted imaging and FLAIR.…”

“…In their re- ports, localization in the precentral gyrus of the SCWM and signal-intensity abnormalities contralateral to the clinically affected side were noted. 1,15 However, in the present study, the localization of white matter signal-intensity abnormalities differed among the 3 cases. In particular, in case 3, T2-weighted imaging and FLAIR showed widespread signal-intensity changes in the frontal lobe white matter bilaterally.…”

“…Koyama et al 1 recently reported asymmetric cerebral atrophy with dominance contralateral to the more clinically affected side, hyperintensity in the subcortical white matter (SCWM) in the frontotemporal area on fluid-attenuated inversion recovery (FLAIR), and atrophy of the midbrain tegmentum as new imaging findings of clinically diagnosed CBD, but no imaging findings in pathologically proved cases have been reported. 3,4 We encountered 4 patients with neuropathologically confirmed CBD in whom the findings could be compared with those of MR imaging.…”

“…We also thought that it was important to identify differences in imaging findings between CBD and PSP, in which severe atrophy of the midbrain tegmentum has been reported. 1,2 Therefore, MR imaging findings in CBD were compared with those in 13 cases of neuropathologically confirmed PSP.…”

Overlapping MRI findings in progressive supranuclear palsy ? corticobasal syndrome

“…, Victor Hugo Marussi 2,3 A 59 year old woman presented with an atypical parkinsonian syndrome with clinical and neuroimaging features of corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). CBS manifestations were slurred/scanning speech and asymmetrical right signs: levitation phenomena, pseudo-hemiparetic gait and hypertonia/hyperreflexia.…”