Imaging of Brown Adipose Tissue: State of the Art

Sampath, Srihari C.; Sampath, Srinath C.; Bredella, Miriam A.; Cypess, Aaron M.; Torriani, Martin

doi:10.1148/radiol.2016150390

Cited by 77 publications

(94 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The latter mentioned beige adipose tissue will not be further addressed in this article, as methods to characterize it with imaging are still in early stages of development [8,9]. MRI is a way to differentiate between white and brown adipose tissue (WAT and BAT) based on their different characteristics from a histological (e. g. based on their water content) and also functional (e. g. based on their blood perfusion) point of view, as described in detail later on in the section "MRI characteristics of white and brown adipose tissue".…”

Section: Types Of Adipose Tissuementioning

confidence: 99%

Magnetic Resonance Imaging of Adipose Tissue in Metabolic Dysfunction

Franz

Syväri

Weidlich

et al. 2018

Fortschr Röntgenstr

View full text Add to dashboard Cite

Section: Types Of Adipose Tissuementioning

confidence: 99%

Magnetic Resonance Imaging of Adipose Tissue in Metabolic Dysfunction

Franz

Syväri

Weidlich

et al. 2018

Fortschr Röntgenstr

View full text Add to dashboard Cite

“…[8][9][10][11][12][13] BAT regulates basal and inducible energy expenditure in humans and is composed of cells that contain numerous lipid droplets, dense packing of mitochondria, and the expression of the mitochondria-associated UCP1 (uncoupling protein 1).…”

Section: See Article By Panagia Et Almentioning

confidence: 99%

“…11 Instead, the chemical energy generated by cellular respiration in brown adipocytes is dissipated in the form of heat, which allows thermogenesis by mammals in cold environments and newborn humans. Traditionally, BAT was considered to be no longer present and possessed no significant physiological functions in adult humans; however, positron emission tomography/computed tomography (PET/ CT) imaging investigations have clearly demonstrated that discreet depots of BAT are still present in human adults.…”

Section: See Article By Panagia Et Almentioning

confidence: 99%

The Gift of Light

Wardak

Nguyen

2018

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

“…In adult humans, where this tissue is present only in scattered amounts around major blood vessels, muscle, or mixed within the more abundant white fat, detection of BAT is still a challenge. 5,6 For BAT detection, fat faction magnetic resonance imaging (MRI) techniques have been proposed. 7 These techniques take advantage of the differences in hydration between brown adipose tissue and white adipose tissue (WAT).…”

mentioning

confidence: 99%

Effect of microscopic susceptibility gradients on chemical‐shift‐based fat fraction quantification in supraclavicular fat

McCallister

Zhang

Burant

et al. 2018

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Susceptibility differences between fat and water can cause changes in the water-fat frequency separation that can negatively affect the accuracy of fat fraction techniques. This may be especially relevant for brown adipose tissue as MRI fat fraction techniques have been proposed for its detection. Purpose To assess the effect of microscopic magnetic susceptibility gradients on the water-fat frequency separation and its impact on chemical-shift based fat fraction quantification techniques in the supraclavicular fat, where brown adipose tissue is commonly found in humans. Study Type Prospective Population/Subjects/Phantom/Specimen/Animal Model Subjects: eleven healthy volunteers, mean age of 26 and mean BMI of 23, three overweight volunteers, mean age of 38 and mean BMI of 33. Phantoms: bovine phantom and intralipid fat emulsion. Simulations: various water-fat distributions. Field Strength/Sequence 6-echo gradient echo chemical-shift-encoded sequence at 3T Assessment Fat fraction values as obtained from a water-fat spectral model accounting for susceptibility-induced water-fat frequency variations were directly compared to traditional spectral models which assume constant water-fat frequency separation. Statistical Tests Two-tail t-tests were used for significance testing(P<0.05.) A BIC difference of 6 between fits was taken as strong evidence of an improved model. Results Phantom experiments and simulation results showed variations of the water-fat frequency separation up to 0.4 ppm and 0.6 ppm, respectively. In the supraclavicular area, the water-fat frequency separation produced by magnetic susceptibility gradients varied by as much as ±0.4 ppm, with a mean of 0.08±0.14 ppm, producing a mean difference in fat fraction of −1.26±5.26%. Conclusions In the supraclavicular fat depot, microscopic susceptibility gradients that exist within a voxel between water and fat compartments can produce variations in the water-fat frequency separation. These variations may produce fat fraction quantification errors of 5% when a spectral model with a fixed water-fat frequency separation is applied, which could impact MR brown fat techniques.

show abstract

Imaging of Brown Adipose Tissue: State of the Art

Cited by 77 publications

References 97 publications

Magnetic Resonance Imaging of Adipose Tissue in Metabolic Dysfunction

Magnetic Resonance Imaging of Adipose Tissue in Metabolic Dysfunction

The Gift of Light

Effect of microscopic susceptibility gradients on chemical‐shift‐based fat fraction quantification in supraclavicular fat

Contact Info

Product

Resources

About