Imaging of Breast Cancer With Optical Coherence Tomography Needle Probes: Feasibility and Initial Results

McLaughlin, Robert A.; Quirk, Bryden C.; Curatolo, Andrea; Kirk, Rodney W.; Scolaro, Loretta; Lorenser, Dirk; Robbins, Peter; Wood, Benjamin A.; Saunders, Christobel; Sampson, David D.

doi:10.1109/jstqe.2011.2166757

Cited by 90 publications

(80 citation statements)

References 42 publications

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“…[15][16][17][18][19] and optical coherence tomography (OCT; refs. [20][21][22] can potentially perform rapid and accurate evaluation of the entire surgical margin intraoperatively. Previously, our laboratory has shown promising results in delineating cancer in ex vivo samples of breast ductal carcinomas using a combination of WFPI and standard OCT (16).…”

Section: Introductionmentioning

confidence: 99%

Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer

et al. 2014

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Intraoperative delineation of breast cancer is a significant problem in surgical oncology. A reliable method for demarcation of malignant breast tissue during surgery would reduce the re-excision rate due to positive margins. We present a novel method of identifying breast cancer margins using combined dye-enhanced wide-field fluorescence polarization imaging for en face cancer margins and polarization-sensitive (PS) optical coherence tomography (OCT) for cross-sectional evaluation. Tumor specimens were collected following breast surgery, stained with methylene blue, and imaged. Wide-field fluorescence polarization images were excited at 640 nm and registered between 660 and 750 nm. Standard and PS OCT images were acquired using a commercial 1,310-nm swept-source system. The imaging results were validated against histopathology. Statistically significant higher fluorescence polarization of cancer as compared with both normal and fibrocystic tumor tissue was measured in all the samples. Fluorescence polarization delineated lateral breast cancer margins with contrast superior to that provided by OCT. However, OCT complemented fluorescence polarization imaging by facilitating cross-sectional inspection of tissue. PS OCT yielded higher contrast between cancer and connective tissue, as compared with standard OCT. Combined PS OCT and fluorescence polarization imaging shows promise for intraoperative delineation of breast cancer. Cancer Res; 74(17); 4685-93. Ó2014 AACR.

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Section: Introductionmentioning

confidence: 99%

Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer

et al. 2014

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“…When voltage was applied to the wires, the coil oscillated and transversely displaced the fiber tip prior to a GRIN lens used for focusing. Additionally, needle-based probes were demonstrated for guidance of breast biopsy [101,102] and delineation of breast tumor boundaries [103]. The 23-gauge probe described in [103], in particular, employed a side-imaging strategy in which the focused light was directed orthogonal to the needle ( Fig.…”

Section: Needle-based Intraoperative Oct Probesmentioning

confidence: 99%

“…Additionally, needle-based probes were demonstrated for guidance of breast biopsy [101,102] and delineation of breast tumor boundaries [103]. The 23-gauge probe described in [103], in particular, employed a side-imaging strategy in which the focused light was directed orthogonal to the needle ( Fig. 2(a)) and transverse optical scanning was achieved by rotating and retracting the probe during imaging.…”

Section: Needle-based Intraoperative Oct Probesmentioning

confidence: 99%

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Review of intraoperative optical coherence tomography: technology and applications [Invited]

Carrasco-Zevallos

Viehland

Keller

et al. 2017

Biomed. Opt. Express

134

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During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeon's depth perception and visualization of instruments and subsurface anatomy. Surgical procedures outside microsurgery, such as breast tumor resections, may also benefit from visualization of the sub-surface tissue structures. The widespread clinical adoption of optical coherence tomography (OCT) in ophthalmology and its growing prominence in other fields, such as cancer imaging, has motivated the development of intraoperative OCT for real-time tomographic visualization of surgical interventions. This article reviews key technological developments in intraoperative OCT and their applications in human surgery. We focus on handheld OCT probes, microscope-integrated OCT systems, and OCT-guided laser treatment platforms designed for intraoperative use. Moreover, we discuss intraoperative OCT adjuncts and processing techniques currently under development to optimize the surgical feedback derivable from OCT data. Lastly, we survey salient clinical studies of intraoperative OCT for human surgery.

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“…Compared to SAW OCE that has a spatial resolution in the order of millimeter and MM OCE that requires external contrast agent, compression OCE provides the highest spatial resolution for elastography and is based on intrinsic mechanical changes during compression [14][15][16][17][18][19]. On the other hand, recently developed fiber optic probes allowed endoscopic OCT imaging/sensing despite small penetration depth of OCT signal [20][21][22][23]. Needle OCE has been used to measure mechanical response from deep tissue [10].…”

Section: Introductionmentioning

confidence: 99%

Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties

Qiu

Wang

et al. 2016

Biomed. Opt. Express

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Abstract:We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allowed us to extract Young's modulus of biological tissue. We experimentally calibrated our qOCE instrument, and validated its effectiveness on tissue mimicking phantoms and biological tissues.

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Imaging of Breast Cancer With Optical Coherence Tomography Needle Probes: Feasibility and Initial Results

Cited by 90 publications

References 42 publications

Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer

Polarization-Sensitive Multimodal Imaging for Detecting Breast Cancer

Review of intraoperative optical coherence tomography: technology and applications [Invited]

Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties

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