Imaging of Brain Metastases of Bronchial Carcinomas with 7 T MRI – Initial Results

Mönninghoff, Christoph; Maderwald, Stefan; Theysohn, JM; Schütt, Philipp; Gauler, Thomas; Kraff, Oliver; Ladd, ME; Ladd, Susanne C.; Wanke, Isabel

doi:10.1055/s-0029-1245440

Cited by 27 publications

(19 citation statements)

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“…The current neurocognitive frameworks for understanding changes in QOL over time requires further refinement and would benefit from the development of imaging biomarkers of radiation effects in order to gain additional insights into the pathogenesis of treatment-related brain injury. To date, there have been no definitive studies to identify specific brain regions that are most vulnerable to radiotherapy, although some authors have suggested that the hippocampus may be particularly sensitive to RT (29–33), and that visual attention and memory are disproportionately impaired in late radiation damage (28, 34–36). …”

Section: Discussionmentioning

confidence: 99%

7-Tesla Susceptibility-Weighted Imaging to Assess the Effects of Radiotherapy on Normal-Appearing Brain in Patients With Glioma

Lupo

Chuang

Chang

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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Purpose The potential effects of radiotherapy on neurocognitive function and quality of life are of great significance in patients with brain tumors. In this study we have used 7T Susceptibility-Weighted-Imaging (SWI) to evaluate the intermediate- and long-term imaging manifestations of RT on normal-appearing brain tissue in patients with treated gliomas. Methods and Materials 7T SWI was performed on twenty-five patients with stable gliomas. Microbleeds were identified as discrete foci of susceptibility that did not correspond to vessels. The number of microbleeds was counted within and outside of the T2-hyperintense lesion. For three patients, radiation dosimetry maps were reconstructed and fused with the 7T SWI data. Results Multiple foci of susceptibility consistent with microhemorrhages were observed in patients two years following chemoradiation. These lesions were not present in patients who were not irradiated. The prevalence of microhemorrhages increased with the time since completion of radiotherapy, and these lesions often extended outside the boundaries of the initial high-dose volume and into the contralateral hemisphere. Conclusions High-field SWI has potential for visualizing the appearance of microbleeds associated with long-term effects of radiotherapy on brain tissue. The ability to visualize these lesions in normal-appearing brain tissue may be important in further understanding the utility of this treatment in patients with longer survival.

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Section: Discussionmentioning

confidence: 99%

7-Tesla Susceptibility-Weighted Imaging to Assess the Effects of Radiotherapy on Normal-Appearing Brain in Patients With Glioma

Lupo

Chuang

Chang

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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“…Despite the higher spatial resolution of 3T or 7T MRI, Mö nninghoff et al (34) reported that the detection of brain metastases on 7T MP-RAGE images was almost equal to 1.5 T MP-RAGE images. However, they showed 7T susceptibility weighted image (SWI) sequence allowed the detection of 20% more microhemorrhages in brain metastases compared to the 1.5 T SWI sequence.…”

Section: Conventional Mr Findingsmentioning

confidence: 99%

Intracranial Metastases: Spectrum of Mr Imaging Findings

et al. 2012

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Intracranial metastatic lesions arise through a number of routes. Therefore, they can involve any part of the central nervous system and their imaging appearances vary.Magnetic resonance imaging (MRI) plays a key role in lesion detection, lesion delineation, and differentiation of metastases from other intracranial disease processes.This article is a reasoned pictorial review illustrating the many faces of intracranial metastatic lesions based on the location -intra-axial metastases, calvarial metastases, dural metastases, leptomeningeal metastases, secondary invasion of the meninges by metastatic disease involving the calvarium and skull base, direct or perineural intracranial extension of head and neck neoplasm, and other unusual manifestations of intracranial metastases.We also review the role of advanced MRI to distinguish metastases from high-grade gliomas, tumor-mimicking lesions such as brain abscesses, and delayed post-radiation changes in radiosurgically treated patients.Intracranial metastases occur in approximately 20-40% of patients with cancer and account for up to 40% of all adult brain neoplasms (1, 2). Cancer is the second leading cause of death in the United States, and the incidence continues to rise, with brain metastases representing an increasing challenge to healthcare providers. Early diagnosis of brain metastasis and intensive, aggressive treatment can reduce the symptoms, improve the patient's quality of life, and prolong survival. Therapeutic considerations have to be individualized, and depend on the patient's neurologic status, dissemination of systemic malignancy, number and location of brain metastases, and sensitivity of the primary tumor to radiation and chemotherapy. Magnetic resonance imaging (MRI) plays a major role in the evaluation and management of patients with metastatic brain tumors. The preferred examination providing the best information about the presence, location, and number of intracranial metastases and their response to treatment is contrast-enhanced MRI (CE-MRI) (3 -5). Although brain parenchyma is more frequently involved, extra-axial metastases are the second most common extra-axial neoplasms in the supratentorial compartment, with leptomeningeal metastases accounting for 8 -10% of patients and dural metastases for 3 -4% (6).This article describes the MR findings of various intracranial metastases, based on the lesion's location, and role of advanced MRI. Skull metastasesCarcinomas of the lung, breast, kidney, and prostate are the most frequent primary neoplasm in skull metastasis. Skull metastases are hyperintense on T2-weighted sequences. On pre-contrast T1-weighted sequences skull metastases are more easily detected, where they appear as hypointense focal marrow lesions. CE-MRI findings are superior for detecting lesions, delineating lesion extent, and determining involvement of the underlying dura or brain (6, 7). On CE-MRI, the lesion may enhance to "normal" T1 marrow signal which require fat saturation (6,8). Skull metastases commonly also involve the adja...

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“…With an increasing field strength, the RF field becomes more inhomogeneous and more susceptible to T2* dephasing effects, potentially improving the detection of blood products in brain MRI [12,14] or impeding diagnostics, when imaging abdominal organs with air-tissue interfaces [6].…”

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confidence: 99%

7 Tesla MR Imaging: Opportunities and Challenges

Umutlu

Ladd

Forsting³

et al. 2013

Fortschr Röntgenstr

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The urge to increase magnetic field strength is driven by a number of potentially beneficial physical changes, possibly resulting in improved MR diagnostics. With the successful introduction of in-vivo ultra-high-field MR imaging, by means of 7 Tesla MRI, the focus of scientific research has been set on compiling different applications of brain and body imaging. This review presents an overview on the current status of 7?T MR imaging, investigating the opportunities as well as challenges associated with ultra-high-field MRI. Citation Format: ??Umutlu L, Ladd ME, Forsting M et?al. 7 Tesla MR?Imaging: Opportunities and Challenges. Fortschr R?ntgenstr 2014; 186: 121???129

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Imaging of Brain Metastases of Bronchial Carcinomas with 7 T MRI – Initial Results

Cited by 27 publications

References 0 publications

7-Tesla Susceptibility-Weighted Imaging to Assess the Effects of Radiotherapy on Normal-Appearing Brain in Patients With Glioma

7-Tesla Susceptibility-Weighted Imaging to Assess the Effects of Radiotherapy on Normal-Appearing Brain in Patients With Glioma

Intracranial Metastases: Spectrum of Mr Imaging Findings

7 Tesla MR Imaging: Opportunities and Challenges

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