Imaging of anti-inflammatory effects of HNO <i>via</i> a near-infrared fluorescent probe in cells and in rat gouty arthritis model

Huang, Yan; Zhang, Xia; He, Na; Wang, Yue; Kang, Qi; Shen, Dazhong; Yu, Fabiao; Chen, Lingxin

doi:10.1039/c8tb02494d

Cited by 40 publications

(17 citation statements)

References 65 publications

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“…Insofar, unfavorable actions can be expected by both of them, in particular, at the mitochondrial level. In fact, most actions of NO + were reported to be detrimental and, in fact, caused ΔΨ mt breakdown and apoptosis induction [ 36 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. The apoptotic effect of NO + was found to be considerably more rapid that that by • NO [ 56 , 57 ].…”

Section: Nitric Oxide Its Congeners and Reactive Productsmentioning

confidence: 99%

“…An alternative may be the earlier suggested reduction of • NO to NO − by ferrocytochrome c [ 66 ]. In contrast to the toxicological findings on HNO, this compound had also been discussed as an anti-inflammatory agent [ 67 ]. It remains to be clarified whether these concepts are truly controversial or reflect different aspects that appear in different concentration ranges.…”

Section: Nitric Oxide Its Congeners and Reactive Productsmentioning

confidence: 99%

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Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds

Hardeland

2021

Molecules

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Melatonin and several of its metabolites are interfering with reactive nitrogen. With the notion of prevailing melatonin formation in tissues that exceeds by far the quantities in blood, metabolites come into focus that are poorly found in the circulation. Apart from their antioxidant actions, both melatonin and N1-acetyl-5-methoxykynuramine (AMK) downregulate inducible and inhibit neuronal NO synthases, and additionally scavenge NO. However, the NO adduct of melatonin redonates NO, whereas AMK forms with NO a stable product. Many other melatonin metabolites formed in oxidative processes also contain nitrosylatable sites. Moreover, AMK readily scavenges products of the CO2-adduct of peroxynitrite such as carbonate radicals and NO2. Protein AMKylation seems to be involved in protective actions.

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Section: Nitric Oxide Its Congeners and Reactive Productsmentioning

confidence: 99%

Section: Nitric Oxide Its Congeners and Reactive Productsmentioning

confidence: 99%

Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds

Hardeland

2021

Molecules

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“…Our novel nanocomposite played a signicant role as an anti-inammatory material in the inhibition of inammation in a rat model of an inamed paw, which is just as important as the crucial role played by nitroxyl (HNO) in the inhibition of induced inammation in a rat model of gouty arthritis. 85…”

Section: Evaluation Of the Anti-inammatory Effectmentioning

confidence: 99%

Sustainable waste management and recycling of Zn–Al layered double hydroxide after adsorption of levofloxacin as a safe anti-inflammatory nanomaterial

et al. 2020

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“…Recently, the NIR fluorescent probe 18 for evaluating the anti-inflammatory effects of HNO in a rat gouty arthritis (GA) model was presented. 74 The emission turn-on behavior of the probe was mediated by HNO-triggered removal of the diphenylphosphinobenzoyl group and concomitant release of the fluorophore. In HEPES buffer (pH 7.4), probe 18 displayed a dramatic emission enhancement at 730 nm upon reaction with HNO upon excitation at 680 nm (Figure 10).…”

Section: Arthritismentioning

confidence: 99%

Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

Hou

Sunwoo

et al. 2020

Chem

152

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play their essential roles in regulating biological events. Their aberrant behaviors are mostly associated with pathophysiological processes. A better understanding of these processes can assuredly help us in examining the pathogenesis and progression of diseases and is beneficial for the ultimate clinical therapy. Numerous fluorescent probes have been developed in the last 5 years for detecting ROS and RNS involved in diverse pathophysiological processes, and these are summarized in this review. Optical properties of the fluorescent probes will be described, and their applications in ROS and RNS detection in pathophysiological models, including in chemical-and bacteria-triggered inflammation, druginduced organ toxicity, specific diseases, injury of different tissues and organs, and other pathophysiological processes, will be elaborated. Finally, we judiciously highlight the achievement, limitations, and future perspectives in this field.

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Imaging of anti-inflammatory effects of HNO via a near-infrared fluorescent probe in cells and in rat gouty arthritis model

Abstract: A mitochondria-targeting near-infrared fluorescent probe, namely, Mito-JN, was developed for determining the generation of nitroxyl in cells and rat models.

Cited by 40 publications

References 65 publications

Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds

Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds

Sustainable waste management and recycling of Zn–Al layered double hydroxide after adsorption of levofloxacin as a safe anti-inflammatory nanomaterial

Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

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