Imaging of a Mediastinal Thymic Carcinoid Tumor With Radiolabeled Somatostatin Analogue

Dg, Cadigan; Pd, Hollett; Pw, Collingwood; E, Ur

doi:10.1097/00003072-199606000-00017

Cited by 17 publications

(10 citation statements)

References 2 publications

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“…The 123 I MIBG scan was also performed in order to detect neuroendocrine tissues, but its sensitivity is unknown in this tumor. We note that SRS detects primary and metastatic thymic tumors, including TNET [7,8,14]. …”

Section: Discussionmentioning

confidence: 99%

“…To our best knowledge, 28 cases of TNET in which SRS was performed have been reported to date in the literature (table 1) [5,7-10,15-18], and only one study in abstract form has reported a patient with TNET with MEN 1 having a "false" negative SRS [17]. Tiffet et al [19] in a study of 12 neuroendocrine tumors arising in the thymus, found that none of the 12 tumors stained positively for somatostatin receptors, while Boix et al in a case of a 33 year-old-woman with MEN 1 described positive somatostatin receptor staining by immunohistochemistry [20].…”

Section: Discussionmentioning

confidence: 99%

“…However, pentetreotide has also been shown to concentrate in primary and metastatic thymic tumors, including thymoma, thymic carcinoma, and TNET [7-9] where subtype SSRT2 is present in high density.…”

Section: Introductionmentioning

confidence: 99%

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Leondi

Koutsikos

Zerva

2005

Int Semin Surg Oncol

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A case of a thymic neuroendocrine tumor and the interpretation problems in a post-surgical Somatostatin Receptor Scintigraphy are presented. In a 53-year-old man with superior vena cava obstruction syndrome an atypical carcinoid of the thymus (neuroendocrine carcinoma of intermediate grade 2), was found at surgery.During his first year of follow-up a Somatostatin Receptor Scintigraphy was recommended. An area of abnormal concentration of the radiopharmaceutical was revealed in the mediastinum at this time.A thorough understanding of the mechanisms of the radiopharmaceutical uptake and of the various clinical settings in which uptake can occur are essential for a proper evaluation of the scintigraphic findings and result in the optimal use of this valuable modality.The literature review provides an overview of this rare type of tumor and insight into the clinical significance of Somatostatin Receptor Scintigraphy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Untitled

Leondi

Koutsikos

Zerva

2005

Int Semin Surg Oncol

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“…Recently, a high in vivo uptake of 111 In-DTPA-d-Phe 1 -octreotide was reported in patients bearing thymic neoplasms (17,18) and a successful treatment with octreotide was reported in one patient with thymoma (19). Recently, a high in vivo uptake of 111 In-DTPA-d-Phe 1 -octreotide was reported in patients bearing thymic neoplasms (17,18) and a successful treatment with octreotide was reported in one patient with thymoma (19).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, SS-R have been demonstrated in vitro in various lymphatic tissues (16). Recently, a high in vivo uptake of 111 In-DTPA-d-Phe 1 -octreotide was shown in patients bearing thymomas and thymic carcinoids (17,18), and a successful treatment with octreotide was reported in one patient with thymoma (19). The presence of SS and SS-R in the thymus suggests their involvement in controlling the immuno-and/or neuroendocrine functions in this organ.…”

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confidence: 99%

In Vitro Characterization of Somatostatin Receptors in the Human Thymus and Effects of Somatostatin and Octreotide on Cultured Thymic Epithelial Cells

et al. 1999

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Somatostatin (SS) and its analogs exert inhibitory effects on secretive and proliferative processes of various cells via high affinity SS receptors (SS-R). SS analogs bind with different affinity to the five cloned SS-R subtypes. Octreotide, an octapeptide SS analog, binds with high affinity to the SS-R subtype 2 (sst2). SS-R have been demonstrated in vivo and in vitro on cells from endocrine and immune systems. Among the lymphatic tissues, the thymus has been shown to contain the highest amount of SS, suggesting a local functional role of the peptide. We investigated the SS distribution and SS-R expression pattern in the normal human thymus using autoradiography, membrane homogenate binding studies, and RT-PCR. In addition, the effect of SS and octreotide on growth of cultured thymic epithelial cells (TEC) was studied. By autoradiography, binding of [125I-Tyr0]-SS-28 and [125I-Tyr3]-octreotide was detected in all seven thymuses studied. Specific [125I-Tyr3]-octreotide binding was shown on membrane preparations from thymuses, while not from cultured thymocytes. RT-PCR showed the expression of sst1, sst2A and sst3 messenger RNA (mRNA) in the thymic tissue, whereas sst1 and sst2A mRNAs were found in isolated TEC. SS mRNA was present in thymic tissue and in isolated TEC. SS and octreotide significantly inhibited 3H-thymidine incorporation in 3 of 3 and 6 of 6 TEC cultures, respectively. The percent inhibition ranged from 38.8 to 66.8% for SS and from 19.1 to 59.5% for octreotide. In conclusion, SS mRNA and sst1, sst2A, and sst3 mRNAs are expressed in the normal human thymus. Cultured TEC selectively express sst1 and sst2A mRNA and respond in vitro to SS and octreotide administration with an inhibition of cell proliferation. These data suggest a paracrine/autocrine role of SS and its receptors in the regulation of cell growth in thymic microenvironment.

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Mediastinal Masses

Laurent¹,

Parrens²

Radiologic-Pathologic Correlations From Head to Toe

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Imaging of a Mediastinal Thymic Carcinoid Tumor With Radiolabeled Somatostatin Analogue

Cited by 17 publications

References 2 publications

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In Vitro Characterization of Somatostatin Receptors in the Human Thymus and Effects of Somatostatin and Octreotide on Cultured Thymic Epithelial Cells

Mediastinal Masses

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