Imaging Musculoskeletal Manifestations of Pediatric Hematologic Malignancies

Tannenbaum, Melissa F.; Noda, Sakura; Cohen, Sara; Rissmiller, Julia G.; Golja, Anna M.; Schwartz, Daniel M.

doi:10.2214/ajr.19.21833

Cited by 11 publications

(2 citation statements)

References 73 publications

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“…백혈병 환자에서 경미한 외상으로 인해 병적 골절이 발생할 수도 있는데, 외상과 관련하여 시행한 근골격 영상에서 골수의 이상 유무를 항상 확인하여 진단을 놓치거나 지체하지 않도록 하여야 한다( Fig. 10 ) ( 25 26 ).…”

Section: 소아의 악성 골수 질환unclassified

MR Imaging Features of Pediatric Bone Marrow

Yeom,

Yoo,

Jeon

et al. 2024

J Korean Soc Radiol

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MRI는 골수의 평가에 있어 가장 예민도가 높은 검사로서 골수 질환의 진단에 있어 매우 중요한 역할을 한다. 그러나, 소아 영상을 자주 접하지 않는 영상의학과 의사들에게는 종종 정상 골수와 병적 골수의 구분이 어려울 수 있고, 소아의 흔한 악성질환인 백혈병이나 신경모세포종의 전이 등 골수를 침범하는 질환들이 임상적으로 다양한 근골격계 증상으로 발현하여 근골격 MRI 검사를 통해 진단되기도 한다. 소아에서 시행되는 MRI를 정확하게 판독하려면 골수의 정상 구성 성분에 대한 이해뿐만 아니라 나이에 따른 골수의 변화(age-related developmental change)와 소아에서 흔하게 골수를 침범하는 질환들에 대한 이해가 중요하다. 본 종설에서는 정상 골수의 구성과 소아 골수의 정상 및 비정상 MRI 소견을 기술하고 백혈병, 신경모세포종의 전이 등의 악성 골수 질환을 중심으로 임상 증례들을 고찰하고자 한다.

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Section: 소아의 악성 골수 질환unclassified

MR Imaging Features of Pediatric Bone Marrow

Yeom,

Yoo,

Jeon

et al. 2024

J Korean Soc Radiol

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“…More than 65% of women treated for various pelvic tumours have hip fracture five years postradiotherapy. Tennenbaum et al [5] stated that 20% of normal osteoporosis patient with fragility fracture reported mortality due to long term hospitalisation. Fixation implant treatment would be impossible on the osteoporosis patient due to weak bone structure.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture

Bakar

Mohamad

Mahmud

et al. 2022

BioMed Research International

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Introduction. Modern radiation therapy has become an effective method to treat and monitor tumour growth in cancer patients. It has proved to be a successful way to minimise mortality rates. However, the adverse effects of radiation have been historical evidence in the clinical environment involving diminishing the quality and density of bone and causing fragility fracture to the bone in the long run. This systematic review was aimed at identifying and evaluating the effects of irradiation on morphology and mechanical properties of murine model bone in previous publications. Methods. A systematic literature review was undertaken following the Preferred Reporting Items for Systemic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive literature search was performed using Scopus, Web of Science, and Science Direct databases (English only studies published between 2015 and 2020). The selected studies were evaluated according to three criteria: (1) criteria for study sample selection; (2) criteria for methodological procedures; and (3) criteria for detection and evaluation. Results. The initial search strategy identified 1408 related studies, 8 of were included based on inclusion and exclusion criteria. This review revealed an association between bone destruction and the magnitude of time and dose postirradiation. We agreed that the effect of radiation on bone morphology and strength primarily is a later stage event but noticeable in both low (1 Gy) and high dose (30 Gy) radiation. Trabecular and cortical bone microstructures were significantly altered at irradiation and contralateral sites. Besides, the mechanical strength was significantly impacted in both shorter and longer periods. Conclusion. Overall, the radiotherapy altered bone microstructures and substantially decreases bone mechanical properties. The alteration was related to quantity and the activity of the osteoblast and osteoclast. Early detection of those most at risk for radiation-induced bone alterations could lead to better prophylactic intervention decisions.

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Pädiatrische Entwicklungsstörungen des muskuloskeletalen Systems

Steinborn

2024

Radiologie

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Imaging Musculoskeletal Manifestations of Pediatric Hematologic Malignancies

Cited by 11 publications

References 73 publications

MR Imaging Features of Pediatric Bone Marrow

MR Imaging Features of Pediatric Bone Marrow

Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture

Pädiatrische Entwicklungsstörungen des muskuloskeletalen Systems

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