Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance

Solon, Eric; Groseclose, M. Reid; Ho, Stacy; Tanaka, Kouji; Nakada, Naoyuki; Linehan, Stefan; Nishidate, Masanobu; Yokoi, Hiroyuki; Kaji, Hidefumi; Urasaki, Yoko; Watanabe, Kenichi; Ishida, Takahiro; Komatsu, Rika; Yoshida, Kenji; Yamazaki, Hiroshi; Saito, Kosuke; Saito, Yoshiro; Tanaka, Yukari

doi:10.1016/j.dmpk.2021.100438

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…Over the past decades, pharmaceutical companies, instrument manufacturers and academic institutions have been actively involved in researching and applying MSI in drug discovery and development. [1][2][3][4][5] Highlighted below are a few key research areas that have been reported to drive MSI application in pharmaceutical research:…”

Section: Perspectivementioning

confidence: 99%

“…Furthermore, compared to QWBA, MSI is less standardized and not as widely accepted by regulatory agencies. 5 To address these challenges, ongoing efforts are being made to improve the field of pharmaceutical MSI. One area of focus is Quantitative MSI (QMSI), which aims to quantify analytes with high precision while measuring their spatial distribution.…”

Section: Perspectivementioning

confidence: 99%

“…The nature of MSI enables the identification of drug molecules and facilitates researchers in studying their localization at the molecular level. Over the past decades, pharmaceutical companies, instrument manufacturers and academic institutions have been actively involved in researching and applying MSI in drug discovery and development 1–5 . Highlighted below are a few key research areas that have been reported to drive MSI application in pharmaceutical research: Advancing of MSI techniques: Pharmaceutical MSI researchers have been focusing on refining existing MSI techniques, such as matrix‐assisted laser desorption/ionization (MALDI), secondary ion mass spectrometry (SIMS) 2 and DropletProbe Mass Spectrometry (DPMS) 6 .…”

Section: Perspectivementioning

confidence: 99%

“…Secondly, in many cases MSI lacks the sensitivity to detect analytes at actual dosing levels. Furthermore, compared to QWBA, MSI is less standardized and not as widely accepted by regulatory agencies 5 …”

Section: Perspectivementioning

confidence: 99%

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From molecules to visuals: Empowering drug discovery and development with mass spectrometry imaging

Chen,

Vavrek,

Cancilla

2024

J Mass Spectrom

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Over the past three decades, mass spectrometry imaging (MSI) has emerged as a valuable tool for the spatial localization of drugs and metabolites directly from tissue surfaces without the need for labels. MSI offers molecular specificity, making it increasingly popular in the pharmaceutical industry compared to conventional imaging techniques like quantitative whole‐body autoradiography (QWBA) and immunohistochemistry, which are unable to distinguish parent drugs from metabolites. Across the industry, there has been a consistent uptake in the utilization of MSI to investigate drug and metabolite distribution patterns, and the integration of MSI with omics technologies in preclinical investigations. To continue the further adoption of MSI in drug discovery and development, we believe there are two key areas that need to be addressed. First, there is a need for accurate quantification of analytes from MSI distribution studies. Second, there is a need for increased interactions with regulatory agencies for guidance on the utility and incorporation of MSI techniques in regulatory filings. Ongoing efforts are being made to address these areas, and it is hoped that MSI will gain broader utilization within the industry, thereby becoming a critical ingredient in driving drug discovery and development.

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Section: Perspectivementioning

confidence: 99%

Section: Perspectivementioning

confidence: 99%

Section: Perspectivementioning

confidence: 99%

Section: Perspectivementioning

confidence: 99%

See 2 more Smart Citations

From molecules to visuals: Empowering drug discovery and development with mass spectrometry imaging

Chen,

Vavrek,

Cancilla

2024

J Mass Spectrom

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“…Furthermore, there is another outstanding mass spectrometry technique, mass spectrometry imaging [ 148 , 149 , 150 , 151 , 152 ], which can play a significant role in promoting the studies of PHAs. Compared with those common mass spectrometry techniques, mass spectrometry imaging can not only get the content information of PAHs throughout the whole sample, but also obtain the information about the distribution of PAHs on a media surface.…”

Section: Prospectsmentioning

confidence: 99%

Contemporary Research Progress on the Detection of Polycyclic Aromatic Hydrocarbons

Zhang

Yuan

et al. 2022

IJERPH

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Polycyclic aromatic hydrocarbons (PAHs) are a class of the most common and widespread contaminants. The accumulation of PAHs has made a certain impact on the environment and is seriously threatening human health. Numerous general analytical methods suitable for PAHs were developed. With the development of economy, the environmental problems of PAHs in modern society are more extensive and prominent, and attract more attention from environmental scientists and analysts. Deeper understanding of the properties of PAHs depends on the advent of detection methods, which can also be more conducive to promoting the protection of the environment. Till now, more sensitive, more high-speed and more high-throughput analytical tools are being invented and have played important roles in the research of PAHs. In this short review article, we focused mainly on the contemporary analytical methods about PAHs. We started with a brief review on the hazards, migration, distribution and traditional analysis methods of PAHs in recent years, including liquid chromatography, gas chromatography, surface enhanced Raman spectroscopy and so on. We also presented the applications of the modern ambient mass spectrometry, especially microwave plasma torch mass spectrometry, in the detection of PAHs, as well as the far out novel results in our lab by using microwave plasma torch (MPT) mass spectrometry; for example, some new insights about Birch reduction, regular hydrogen addition and the robustness of molecular structure. These studies have demonstrated the versatility of MPT MS as a platform in the research of PAHs.

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A survey of imaging mass spectrometry methods in the pharmaceutical industry: initial steps to establishing best practices for use in a regulated environment

Solon

2022

Visualizing and Quantifying Drug Distribution in Tissue VI

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Imaging Mass Spectrometry (IMS) for drug discovery and development survey: Results on methods, applications and regulatory compliance

Cited by 4 publications

References 18 publications

From molecules to visuals: Empowering drug discovery and development with mass spectrometry imaging

From molecules to visuals: Empowering drug discovery and development with mass spectrometry imaging

Contemporary Research Progress on the Detection of Polycyclic Aromatic Hydrocarbons

A survey of imaging mass spectrometry methods in the pharmaceutical industry: initial steps to establishing best practices for use in a regulated environment

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