Imaging macrophage distribution and density in mammary tumors and lung metastases using fluorine‐19 MRI cell tracking

Makela, Ashley V.; Foster, Paula J.

doi:10.1002/mrm.27081

Cited by 37 publications

(35 citation statements)

References 40 publications

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“…Dual-contrast agents for 19 F-MRI and fluorescence, e.g. perfluorocarbon-TexasRed, have been used to track tumour-associated macrophages in mice ( Makela and Foster, 2018 ). MRI reporter genes have also been developed ( Table 1 ) and have the advantage of co-registration with soft-tissue anatomy and certain functional imaging parameters.…”

Section: Multi-modal Imaging Is Necessary For In Vivo mentioning

confidence: 99%

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking

Volpe

Kurtys

Fruhwirth

2018

The International Journal of Biochemistry & Cell Biology

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Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging. Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques.

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Section: Multi-modal Imaging Is Necessary For In Vivo mentioning

confidence: 99%

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking

Volpe

Kurtys

Fruhwirth

2018

The International Journal of Biochemistry & Cell Biology

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“…These types of labelling agents include fluorinated emulsions (CS-1000 and VS-1000H) and other fluorescently tagged formulations (CS-ATM DM Red, Green, NIR) for ex vivo and in situ cell labels. 133 , 134 A recent study showed that it is possible to effectively label hMSCs with cell sense without affecting cell viability, function or differentiation. The bSSFP sequence was used to detect and quantify the signal of Cell Sense-labeled hMSC cells in vitro and in intramuscular implantation.…”

Section: Cell Trackingmentioning

confidence: 99%

<p>Perfluorocarbons-Based <sup>19</sup>F Magnetic Resonance Imaging in Biomedicine</p>

Liu

et al. 2020

IJN

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Fluorine-19 (19 F) magnetic resonance (MR) molecular imaging is a promising noninvasive and quantitative molecular imaging approach with intensive research due to the high sensitivity and low endogenous background signal of the 19 F atom in vivo. Perfluorocarbons (PFCs) have been used as blood substitutes since 1970s. More recently, a variety of PFC nanoparticles have been designed for the detection and imaging of physiological and pathological changes. These molecular imaging probes have been developed to label cells, target specific epitopes in tumors, monitor the prognosis and therapy efficacy and quantitate characterization of tumors and changes in tumor microenvironment noninvasively, therefore, significantly improving the prognosis and therapy efficacy. Herein, we discuss the recent development and applications of 19 F MR techniques with PFC nanoparticles in biomedicine, with particular emphasis on ligand-targeted and quantitative 19 F MR imaging approaches for tumor detection, oxygenation measurement, smart stimulus response and therapy efficacy monitoring, et al.

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“…Several groups, Khurana et al [120], Makela et al [121] and Huyn Shin et al [122], have also reported 19 F-based MRI cell tracking by using in vivo PFC-labelled nanoparticles to detect, quantify and track TAMs inside murine orthotopic breast cancer tumors and its associated metastasis or in mouse model of head and neck squamous cells carcinoma.…”

Section: Cell Trackingmentioning

confidence: 99%

Fluorinated MRI Contrast Agents and Their Versatile Applications in the Biomedical Field

et al. 2019

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MRI has been recognized as one of the most applied medical imaging techniques in clinical practice. However, the presence of background signal coming from water protons in surrounding tissues makes sometimes the visualization of local contrast agents difficult. To remedy this, fluorine has been introduced as a reliable perspective, thanks to its magnetic properties being relatively close to those of protons. In this review, we aim to give an overall description of fluorine incorporation in contrast agents for MRI. The different kinds of fluorinated probes such as perfluorocarbons, fluorinated dendrimers, polymers and paramagnetic probes will be described, as will their imaging applications such as chemical exchange saturation transfer (CEST) imaging, physico-chemical changes detection, drug delivery, cell tracking and inflammation or tumors detection.

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Imaging macrophage distribution and density in mammary tumors and lung metastases using fluorine‐19 MRI cell tracking

Cited by 37 publications

References 40 publications

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking

Cousins at work: How combining medical with optical imaging enhances in vivo cell tracking

<p>Perfluorocarbons-Based <sup>19</sup>F Magnetic Resonance Imaging in Biomedicine</p>

Fluorinated MRI Contrast Agents and Their Versatile Applications in the Biomedical Field

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