Imaging Intracranial Vessel Wall Pathology With Magnetic Resonance Imaging

Dieleman, Nikki; Kolk, Anja G. van der; Zwanenburg, Jaco J.M.; Harteveld, Anita A.; Biessels, Geert Jan; Luijten, Peter R.; Hendrikse, Jeroen

doi:10.1161/circulationaha.113.006919

Cited by 149 publications

(138 citation statements)

References 78 publications

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“…Recent advances in MR imaging have made it possible to reliably image intracranial vessel wall pathologies, including ICAS. 19 Vessel wall MR imaging can reveal the presence of atherosclerotic plaques or focal thickening and enhancement of the intracranial vessel wall in patients with ICAS. In addition, recent studies showed that vessel wall MR imaging might be used for the characterization of intracranial atherosclerotic plaques to assess the vulnerability of these plaques.…”

Section: Discussionmentioning

confidence: 99%

Negative Susceptibility Vessel Sign and Underlying Intracranial Atherosclerotic Stenosis in Acute Middle Cerebral Artery Occlusion

Kim¹,

Yoon²,

Heo³

et al. 2015

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

Negative Susceptibility Vessel Sign and Underlying Intracranial Atherosclerotic Stenosis in Acute Middle Cerebral Artery Occlusion

Kim¹,

Yoon²,

Heo³

et al. 2015

American Journal of Neuroradiology

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“…The solution currently available to clinicians heavily relies on luminography imaging, with which the stenotic degree is a primary criterion for defining a culprit or high‐risk lesion. However, extensive research on the atherosclerosis disease has suggested that lumen narrowing may not be a reliable indicator of plaque severity because of positive remodeling of the vessel wall,8 and the features exhibited directly by plaques may provide complementary information 9, 10…”

Section: Introductionmentioning

confidence: 99%

Differential Features of Culprit Intracranial Atherosclerotic Lesions: A Whole‐Brain Vessel Wall Imaging Study in Patients With Acute Ischemic Stroke

Song

et al. 2018

JAHA

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BackgroundIntracranial atherosclerotic disease tends to affect multiple arterial segments. Using whole‐brain vessel wall imaging, we sought to study the differences in plaque features among various types of plaques in patients with a recent unilateral anterior circulation ischemic stroke.Methods and ResultsSixty‐one patients with unilateral anterior circulation ischemic stroke were referred to undergo whole‐brain vessel wall imaging (before and after contrast) within 1 month of symptom onset for intracranial atherosclerotic disease evaluations. Each plaque was classified as a culprit, probably culprit, or nonculprit lesion, according to its likelihood of causing the stroke. The associations between plaque features (thickening pattern, plaque‐wall contrast ratio, high signal on T1‐weighted images, plaque contrast enhancement ratio, enhancement grade, and enhancement pattern) and culprit lesions were estimated using mixed multivariable logistic regression after adjustment for maximum wall thickness. In 52 patients without motion corruption in whole‐brain vessel wall imaging, a total of 178 intracranial plaques in the anterior circulation were identified, including 52 culprit lesions (29.2%), 51 probably culprit lesions (28.7%), and 75 nonculprit lesions (42.1%). High signal on T1‐weighted images (adjusted odds ratio, 9.1; 95% confidence interval, 1.9–44.1; P=0.006), grade 2 (enhancement ratio of plaque ≥ enhancement ratio of pituitary) contrast enhancement (adjusted odds ratio, 17.4; 95% confidence interval, 1.8–164.9; P=0.013), and type 2 (≥50% cross‐sectional wall involvement) enhancement pattern (adjusted odds ratio, 10.1; 95% confidence interval, 1.3–82.2; P=0.030) were independently associated with culprit lesions.ConclusionsHigh signal on T1‐weighted images, grade 2 contrast enhancement, and type 2 enhancement pattern are associated with cerebrovascular ischemic events, which may provide valuable insights into risk stratification.

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“…[1][2][3][4] Previous reports established a link between ruptured aneurysms and wall enhancement by using qualitative vessel wall MR imaging assessments. 1,5,6 However wall enhancement was also observed in unruptured aneurysms 1,6 ; thus, we hypothesized that the degree of enhancement is higher in ruptured than in unruptured aneurysms.…”

mentioning

confidence: 99%

Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging

Omodaka¹,

Endo²,

Niizuma

et al. 2016

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:The incidence of wall enhancement of cerebral aneurysms on vessel wall MR imaging has been described as higher in ruptured intracranial aneurysms than in unruptured intracranial aneurysms, but the difference in the degree of enhancement between ruptured and unruptured aneurysms is unknown. We compared the degree of enhancement between ruptured and unruptured intracranial aneurysms by using quantitative MR imaging measures.

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Imaging Intracranial Vessel Wall Pathology With Magnetic Resonance Imaging

Cited by 149 publications

References 78 publications

Negative Susceptibility Vessel Sign and Underlying Intracranial Atherosclerotic Stenosis in Acute Middle Cerebral Artery Occlusion

Negative Susceptibility Vessel Sign and Underlying Intracranial Atherosclerotic Stenosis in Acute Middle Cerebral Artery Occlusion

Differential Features of Culprit Intracranial Atherosclerotic Lesions: A Whole‐Brain Vessel Wall Imaging Study in Patients With Acute Ischemic Stroke

Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging

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