Imaging in urethral stricture disease: an educational review of current techniques with a focus on MRI

Harris, Daniel; Zhou, Christopher; Girardot, Jeffrey; Kidron, Ariel; Gupta, Shubham; Cavalcanti, André G.; Bittencourt, Leonardo Kayat

doi:10.1007/s00261-022-03761-5

Cited by 6 publications

(9 citation statements)

References 42 publications

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“…1 Urethral diseases are usually evaluated using retrograde urethrography, voiding cystourethrography, ultrasound with or without a contrast agent, and magnetic resonance imaging. 2 Among these modalities, ultrasound is paramount in pediatric patients owing to the lack of radiation exposure, sedation, and real-time evaluation at the patient's bedside. Various sonographic approaches have been used to evaluate the urethra that is, via the bladder, transperineal, or just on the penis (Figure 1A).…”

Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

“…Urethra is involved in various diseases such as congenital obstruction, malignant, and infectious diseases, or traumatic changes 1 . Urethral diseases are usually evaluated using retrograde urethrography, voiding cystourethrography, ultrasound with or without a contrast agent, and magnetic resonance imaging 2 . Among these modalities, ultrasound is paramount in pediatric patients owing to the lack of radiation exposure, sedation, and real‐time evaluation at the patient's bedside.…”

Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

“…Various sonographic approaches have been used to evaluate the urethra that is, via the bladder, transperineal, or just on the penis (Figure 1A). Male urethra is divided into two parts: posterior and anterior 1,2 . The posterior urethra includes prostate and membranous urethra, whereas the anterior urethra includes bulbar and penile urethra 1,2 .…”

Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

“…Male urethra is divided into two parts: posterior and anterior 1,2 . The posterior urethra includes prostate and membranous urethra, whereas the anterior urethra includes bulbar and penile urethra 1,2 . Herein, we present ultrasound images of various urethral lesions in pediatric patients.Case Posterior urethral valve.…”

Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

See 3 more Smart Citations

Ultrasound for the evaluation of the urethra in pediatric patients

Hosokawa,

Ohashi,

Yoshizawa

et al. 2024

J of Clinical Ultrasound

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Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

Section: Ultrasound For the Evaluation Of The Urethra In Pediatric Pa...mentioning

confidence: 99%

See 2 more Smart Citations

Ultrasound for the evaluation of the urethra in pediatric patients

Hosokawa,

Ohashi,

Yoshizawa

et al. 2024

J of Clinical Ultrasound

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“…In the intricate landscape of urethral stricture management, the meticulous diagnosis and precise assessment of stricture intricacies serve as pivotal guides for surgical decision-making 1 . Imaging, positioned at the core of this diagnostic endeavor, assumes a paramount role in unraveling the nuanced details of the stricture.…”

Section: Introductionmentioning

confidence: 99%

Optimizing Anterior Urethral Stricture Assessment: Leveraging AI-Assisted Three-Dimensional Sonourethrography in Clinical Practice

Feng,

Lu,

Xue

et al. 2024

Preprint

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Purpose This investigation sought to validate the clinical precision and practical applicability of AI-enhanced three-dimensional sonographic imaging for the identification of anterior urethral stricture. Methods The study enrolled 63 male patients with diagnosed anterior urethral strictures alongside 10 healthy volunteers to serve as controls. The imaging protocol utilized a high-frequency 3D ultrasound system combined with a linear stepper motor, which enabled precise and rapid image acquisition. For image analysis, an advanced AI-based segmentation process using a modified U-net algorithm was implemented to perform real-time, high-resolution segmentation and three-dimensional reconstruction of the urethra. A comparative analysis was performed against the surgically measured stricture lengths. Spearman’s correlation analysis was executed to assess the findings. Results The AI model completed the entire processing sequence, encompassing recognition, segmentation, and reconstruction, within approximately 5 minutes. The mean intraoperative length of urethral stricture was determined to be 14.452 ± 8.385 mm. Notably, the mean lengths of the urethral strictures reconstructed by manual and AI models were 13.092 ± 7.463 mm and 13.419 ± 7.216 mm, respectively. Interestingly, no statistically significant disparity in urethral stricture length between manually reconstructed and AI-reconstructed images was observed. Spearman’s correlation analysis underscored a more robust association of AI-reconstructed images with intraoperative urethral stricture length than manually reconstructed 3D images (0.869811 vs. 0.8201756). Furthermore, AI-reconstructed images provided detailed views of the corpus spongiosum fibrosis from multiple perspectives. Conclusions The research heralds the inception of an innovative, efficient AI-driven sonographic approach for three-dimensional visualization of urethral strictures, substantiating its viability and superiority in clinical application

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Overexpressed miR‐486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats

Xu,

Huang,

Qiu

et al. 2024

Journal of Cell Communication and Signaling

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Urethral stricture (US) is a challenging problem in urology and its pathogenesis of US is closely related to the fibrotic process. Previous evidence has indicated the downregulation of microRNA (miR)‐486 in injured urethral specimens of rats. This study aimed to explore the effects of miR‐486‐overexpressed bone marrow mesenchymal stem cells (BMSCs) on US. BMSCs were identified by detecting their multipotency and surface antigens. Lentivirus virus expressing miR‐486 was transduced into rat BMSCs to overexpress miR‐486. Transforming growth factor (TGF)‐β1 induced fibrotic phenotypes in urethral fibroblasts (UFs) and rat models. Western blotting showed protein levels of collagen I/III and collagen type XIII alpha 1 chain (Col13a1). Real time quantitative polymerase chain reaction was utilized for messenger RNA level evaluation. Hematoxylin‐eosin, Masson's trichrome, and Von Willebrand Factor staining were conducted for histopathological analysis. Immunofluorescence staining was employed for detecting alpha smooth muscle actin (α‐SMA) expression. Luciferase reporter assay verified the interaction between miR‐486 and Col13a1. The results showed that miR‐486‐overexpressed BMSCs suppressed collagen I/III and α‐SMA expression in TGF‐β1‐stimulated UFs. miR‐486‐overexpressed BMSCs alleviated urethral fibrosis, collagen deposition, and epithelial injury in the urethral tissue of US rats. miR‐486 targeted and negatively regulated Col13a1 in US rats. In conclusion, overexpression of miR‐486 in BMSCs targets Col13a1 and attenuates urethral fibrosis in TGF‐β1‐triggered UFs and US rats.

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Imaging in urethral stricture disease: an educational review of current techniques with a focus on MRI

Cited by 6 publications

References 42 publications

Ultrasound for the evaluation of the urethra in pediatric patients

Ultrasound for the evaluation of the urethra in pediatric patients

Optimizing Anterior Urethral Stricture Assessment: Leveraging AI-Assisted Three-Dimensional Sonourethrography in Clinical Practice

Overexpressed miR‐486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats

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