Imaging in Tuberculosis

Bomanji, Jamshed; Gupta, Neil; Gulati, Parveen; Das, Chandan Jyoti

doi:10.1101/cshperspect.a017814

Cited by 67 publications

(63 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies suggest that sensitivities from automated readers can be similar to those obtained by eye but that specificity is reduced [27], a finding confirmed by studies in Africa [28,29]. Alternative imaging technologies such as magnetic resonance imaging, computed tomography, and positron emission tomography-computed tomography (PET-CT) may eventually find utility in the investigation of extrapulmonary disease [26]. PET-CT is another modality that is being explored for tuberculosis [19].…”

Section: Imagingmentioning

confidence: 76%

“…A number of imaging techniques can be used to gauge the extent of disease and to monitor treatment, and imaging remains a first-line tool for investigating extrapulmonary manifestations of the disease [26]. Chest radiography played a major role in reducing the prevalence of tuberculosis in Europe and North America in the 1950s and 1960s, with mobile radiograph units used for mass screening of communities.…”

Section: Imagingmentioning

confidence: 99%

See 1 more Smart Citation

Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines

et al. 2015

View full text Add to dashboard Cite

Despite concerted efforts over the past 2 decades at developing new diagnostics, drugs, and vaccines with expanding pipelines, tuberculosis remains a global emergency. Several novel diagnostic technologies show promise of better point-of-care rapid tests for tuberculosis including nucleic acid-based amplification tests, imaging, and breath analysis of volatile organic compounds. Advances in new and repurposed drugs for use in multidrug-resistant (MDR) or extensively drug-resistant (XDR) tuberculosis have focused on development of several new drug regimens and their evaluation in clinical trials and now influence World Health Organization guidelines. Since the failure of the MVA85A vaccine 2 years ago, there have been no new tuberculosis vaccine candidates entering clinical testing. The current status quo of the lengthy treatment duration and poor treatment outcomes associated with MDR/XDR tuberculosis and with comorbidity of tuberculosis with human immunodeficiency virus and noncommunicable diseases is unacceptable. New innovations and political and funder commitment for early rapid diagnosis, shortening duration of therapy, improving treatment outcomes, and prevention are urgently required.

show abstract

Section: Imagingmentioning

confidence: 76%

Section: Imagingmentioning

confidence: 99%

Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines

et al. 2015

View full text Add to dashboard Cite

show abstract

“…At radiology, primary PTB manifests as four main entities -parenchymal disease, lymphadenopathy, pleural effusion, and miliary disease -or any combination thereof. 1 Chest radiography continues to be the mainstay of diagnosis. Typically, parenchymal disease manifests as consolidation in any lobe, with predominance in the lower and middle lobes.…”

Section: Primary Tuberculosismentioning

confidence: 99%

“…Although new imaging methods are now being used, conventional radiography remains the initial modality for suspected PTB and for mass screening purposes. 1 CT and MRI are the modalities of choice for the evaluation of specific body parts. 1 Positron emission tomography/computed tomography with the use of 18 F-fluorodeoxyglucose ( 18 F-FDG PET/CT) is a non-invasive imaging method that has been used widely for the differentiation of malignant from benign lesions.…”

Section: Introductionmentioning

confidence: 99%

“…1 CT and MRI are the modalities of choice for the evaluation of specific body parts. 1 Positron emission tomography/computed tomography with the use of 18 F-fluorodeoxyglucose ( 18 F-FDG PET/CT) is a non-invasive imaging method that has been used widely for the differentiation of malignant from benign lesions. However, 18 F-FDG also accumulates in inflammatory cells such as neutrophils, activated macrophages, and lymphocytes at the site of inflammation or infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging in tuberculosis

Skoura

Zumla

Bomanji

2015

International Journal of Infectious Diseases

235

182

View full text Add to dashboard Cite

Early diagnosis of tuberculosis (TB) is necessary for effective treatment. In primary pulmonary TB, chest radiography remains the mainstay for the diagnosis of parenchymal disease, while computed tomography (CT) is more sensitive in detecting lymphadenopathy. In post-primary pulmonary TB, CT is the method of choice to reveal early bronchogenic spread. Concerning characterization of the infection as active or not, CT is more sensitive than radiography, and (18)F-fluorodeoxyglucose positron emission tomography/CT ((18)F-FDG PET/CT) has yielded promising results that need further confirmation. The diagnosis of extrapulmonary TB sometimes remains difficult. Magnetic resonance imaging (MRI) is the preferred modality in the diagnosis and assessment of tuberculous spondylitis, while (18)F-FDG PET shows superior image resolution compared with single-photon-emitting tracers. MRI is considered superior to CT for the detection and assessment of central nervous system TB. Concerning abdominal TB, lymph nodes are best evaluated on CT, and there is no evidence that MRI offers added advantages in diagnosing hepatobiliary disease. As metabolic changes precede morphological ones, the application of (18)F-FDG PET/CT will likely play a major role in the assessment of the response to anti-TB treatment.

show abstract