Imaging in psychiatric illnesses

Gupta, Adarsh; El-Heis, Mwaffaq; Pansari, K

doi:10.1111/j.1742-1241.2004.00224.x

Cited by 12 publications

(2 citation statements)

References 80 publications

(81 reference statements)

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“…A correlation was only found after reduction of intersubject variation in CMR glc by scaling to the global CMR glc . Scaled CMR glc showed a significant correlation with depression scores in some areas, which have been shown to be affected in depression in former studies: the orbitofrontal cortex, the cingulate gyrus, and the hippocampal region (Gupta et al, 2004;Kimbrell et al, 2002). It should be noted that scaling of CMR glc to global CMR glc can result in scaling artefacts as described for example in the study by Borghammer et al (2008).…”

Section: Discussionmentioning

confidence: 87%

Cerebral Glucose Utilisation in Hepatitis C Virus Infection-Associated Encephalopathy

Heeren

Weißenborn

Arvanitis

et al. 2011

J Cereb Blood Flow Metab

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Patients with hepatitis C virus (HCV) infection frequently show neuropsychiatric symptoms. This study aims to help clarify the neurochemical mechanisms behind these symptoms and to add further proof to the hypothesis that HCV may affect brain function. Therefore, 15 patients who reported increasing chronic fatigue, mood alterations, and/or cognitive decline since their HCV infection underwent neurologic and neuropsychological examination, magnetic resonance imaging, (18)F-fluoro-deoxy-glucose positron emission tomography of the brain, and single photon emission tomography of striatal dopamine and midbrain serotonin transporter (SERT) availability. None of the patients had liver cirrhosis. Patients' data were compared with data of age-matched controls. In addition, regression analysis was performed between cognitive deficits, and mood and fatigue scores as dependent variables, and cerebral glucose metabolism, dopamine, or SERT availability as predictors. Patients showed significant cognitive deficits, significantly decreased striatal dopamine and midbrain SERT availability, and significantly reduced glucose metabolism in the limbic association cortex, and in the frontal, parietal, and superior temporal cortices, all of which correlated with dopamine transporter availability and psychometric results. Thus, the study provides further evidence of central nervous system affection in HCV-afflicted patients with neuropsychiatric symptoms. Data indicate alteration of dopaminergic neurotransmission as a possible mechanism of cognitive decline.

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Section: Discussionmentioning

confidence: 87%

Cerebral Glucose Utilisation in Hepatitis C Virus Infection-Associated Encephalopathy

Heeren

Weißenborn

Arvanitis

et al. 2011

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Although hyperactivation of brain regions has been reported (Callicott et al, 2000;Manoach et al, 2001;Quintana et al, 2001), recent meta-analyses suggest that the most consistent finding is hypoactivation, or increased variability, in frontal and temporal lobes for SP compared with HNV (Davidson & Heinrichs, 2003;Glahn et al, 2005). Although the exact mechanism or mechanisms producing the hypoactivation in SP are still being debated (Callicott et al, 1998;Callicott & Weinberger, 1999Davidson & Heinrichs, 2003;Gupta et al, 2004;Weinberger et al, 1996), possible explanations include disease-related neuronal pathology, neuronal pathology resulting from secondary disease characteristics, inefficient cognitive strategies, medication effects, and differences in behavioral performance.…”

Section: Introductionmentioning

confidence: 99%

Assessment and quantification of head motion in neuropsychiatric functional imaging research as applied to schizophrenia

Mayer

Franco

Ling³

et al. 2007

J. Inter. Neuropsych. Soc.

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Differing degrees of head motion have long been recognized as a potential confound in functional neuroimaging studies comparing neuropsychiatric populations to healthy normal volunteers, and studies often cite excessive head motion as a possible reason for the different patterns of functional activation frequently observed between groups. We empirically tested the degree of head motion in 16 patients with chronic schizophrenia and 16, age- and education-matched controls during the acquisition of functional magnetic resonance imaging data. We examined the degree of motion across three different indices (total motion, relative motion, task-correlated motion) during a complex attentional task and the effect of entering the motion parameters as additional regressors in a general linear model analysis. Results indicate that individuals with schizophrenia did not exhibit more task-correlated or total motion compared with controls. Moreover, the residual error term from the general linear model analysis was similar for both groups of subjects. In conclusion, current results suggest that stable patients with schizophrenia are capable of controlling head motion compared with matched normal controls. However, a direct comparison of the motion parameters is an essential step for any quality assurance protocol to determine whether additional corrective techniques need to be implemented.

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Virginia Woolf’s Suicide

Bennett¹

2012

Virginia Woolf and Neuropsychiatry

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Imaging in psychiatric illnesses

Cited by 12 publications

References 80 publications

Cerebral Glucose Utilisation in Hepatitis C Virus Infection-Associated Encephalopathy

Cerebral Glucose Utilisation in Hepatitis C Virus Infection-Associated Encephalopathy

Assessment and quantification of head motion in neuropsychiatric functional imaging research as applied to schizophrenia

Virginia Woolf’s Suicide

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