Imaging in neurooncology

Kracht, Lutz W.; Goßmann, Axel; Rüger, Maria Adele; Thomas, Anne; Thiel, Alexander; Herholz, Karl

doi:10.1007/bf03206675

Cited by 29 publications

(57 citation statements)

References 141 publications

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“…Recently, PET data and MRI data have been retrospectively combined for detection and staging of gliomas [19,20] as well as for identification of areas with critical neurofunction in the vicinity of tumours, which is important for planning surgery [21]. Image fusion has gained a place in the early diagnosis of dementia and mild cognitive impairment [22] and degenerative disorders, e.g.…”

Section: Advantages Of An Integrated Pet/mr System For Image Fusionmentioning

confidence: 99%

The potential of PET/MR for brain imaging

Heiss

2008

Eur J Nucl Med Mol Imaging

131

100

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Introduction The completion of an integrated PET/MR prototype system for brain imaging is the latest step in the evolution of positron emission tomography. Early images with this new imaging system demonstrate that highresolution multiparametric studies can be combined without significant loss of performance of either imaging modality. Objective This new technology will make fusion of morphological and biological information much easier, yield real-time assessment of complementary variables and will provide dynamic information for kinetic model- IntroductionSince the first prototypes [1, 2] and the first commercial system [3], positron emission tomography (PET) has developed to multiring systems permitting high resolution and three-dimensional imaging of various physiological, functional and molecular targets. The first applications of PET were in brain research, and despite the many other diagnostic indications, particularly in oncology and cardiology, brain imaging remains a stronghold of PET.Therefore, this discussion of perspectives of an integrated PET/MR system is focused on research applications in neuroscience to which the combination of PET and MRI may add further impetus. This perspective is in parts speculative and it does not include a discussion of the technical or methodological challenges of combined PET/ MR imaging. These aspects are reviewed elsewhere in the articles of this supplement to EJNMMI. Development of PET for brain imagingThe progress in image quality may be followed by metabolic images of glucose consumption in one volunteer acquired on several generation PET systems over the years. The first transaxial image (Fig. 1a) was acquired on a single hexagonal array, the ECAT PET, which covered only the cortical rim. Early PET images suffered from limited spatial resolution (approximately 15 mm), low sensitivity and insufficient attenuation and scatter correction [3,4]. PET image quality improved with the four-ring PC-384 (Scanditronix) [5], which yielded seven simultaneous, partly overlapping transaxial images and that provided a spatial resolution of 8.4 mm FWHM across 12-mm slices (Fig. 1b) [6] and limited axial reconstruction (Fig. 2). Further improvements came with the Eur

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Section: Advantages Of An Integrated Pet/mr System For Image Fusionmentioning

confidence: 99%

The potential of PET/MR for brain imaging

Heiss

2008

Eur J Nucl Med Mol Imaging

131

100

View full text Add to dashboard Cite

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“…To enable assessment of the dynamic changes occurring in gliomas, noninvasive imaging is being implemented in patients (8,9) and translated into model systems (10,11).…”

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confidence: 99%

Analysis of the Growth Dynamics of Angiogenesis-Dependent and -Independent Experimental Glioblastomas by Multimodal Small-Animal PET and MRI

Viel¹,

Talasila²,

Monfared³

et al. 2012

J Nucl Med

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“…FDG accumulation reflects the rate of glucose utilization in a tissue, and mapping of FDG uptake within the body is altered in various inflammatory and neoplastic diseases [16]. Therefore, FDG-PET has assumed an increasingly important role in clinics and neurosciences by detecting the alteration of glucose utilization shown in various intracranial diseases [10,13,15,25,28]. Recently, FDG-PET has become available in veterinary medicine to obtain metabolic information of intracranial inflammation and tumor [8,17,19].…”

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confidence: 99%

FDG Uptake of Normal Canine Brain Assessed by High-Resolution Research Tomography-Positron Emission Tomography and 7 T-Magnetic Resonance Imaging

et al. 2012

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ABSTRACT. The purpose of this study was to assess the normal distribution of 18 F-fluoro-2-deoxy-D-glucose (FDG) uptake of canine brain structures using a high-resolution research tomography-positron emission tomography (HRRT-PET) and 7 T-magnetic resonance imaging (MRI) fusion system. FDG-PET and T2-weighted MRI of the brain were performed on 4 healthy laboratory beagle dogs. On MRI, regions of interests (ROIs) were manually drawn over 51 intracranial structures, including nine gross structures and 42 detailed structures. Relative standard uptake value ratio (rSUV=SUV of ROI/SUV of whole brain) was calculated for each ROI. The HRRT-PET and 7 T-MRI fusion imaging system demonstrated significant differences in glucose metabolism among various intracranial structures. Among gross structures, the midbrain and the pons and medulla oblongata had the highest uptake (rSUV: 1.12 ± 0.03) and lowest uptake (rSUV: 0.90 ± 0.06) of FDG, respectively. When rSUVs were calculated on detailed regions, the caudal colliculus and the longitudinal fibers of pons had the highest (rSUV: 1.62 ± 0.05) and the lowest (rSUV: 0.63 ± 0.03) glucose metabolism, respectively. Because the high resolution of PET-MRI fusion images provided clearly identifiable metabolic activities of canine brain, the HRRT-PET and 7 T-MRI fusion imaging might be a good tool for evaluation of intracranial diseases in canines. KEY WORDS: 7 T-MRI, canine brain, FDG, HRRT-PET.

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Imaging in neurooncology

Cited by 29 publications

References 141 publications

The potential of PET/MR for brain imaging

The potential of PET/MR for brain imaging

Analysis of the Growth Dynamics of Angiogenesis-Dependent and -Independent Experimental Glioblastomas by Multimodal Small-Animal PET and MRI

FDG Uptake of Normal Canine Brain Assessed by High-Resolution Research Tomography-Positron Emission Tomography and 7 T-Magnetic Resonance Imaging

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