Imaging haemopoietic stem cells and microenvironment dynamics through transplantation

Williams, Kirsten M.; Chakrabarty, Jennifer Holter

doi:10.1016/s2352-3026(20)30003-x

Cited by 4 publications

(2 citation statements)

References 50 publications

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“…T-cell reconstitution after ASCT is mediated by the homeostatic proliferation and generation of newborn T-cells through thymopoiesis. Restoration in the early post-transplant period is predominantly mediated by the homeostatic proliferation of CD8+ memory T-cells[ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Zhang¹,

Dou²,

Yan³

et al. 2023

World J Clin Cases

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BACKGROUND Angioimmunoblastic T-cell lymphoma (AITL), a unique subtype of peripheral T-cell lymphoma, has relatively poor outcomes. High-dose chemotherapy with autologous stem cell transplantation (ASCT) can achieve complete remission and improve outcomes. Unfortunately, subsequent T-cell lymphoma-triggered hemophagocytic lymphohistiocytosis (HLH) has a worse prognosis than B-cell lymphoma-triggered HLH. CASE SUMMARY We here report a 50-year-old woman with AITL who achieved a favorable outcome after developing HLH 2 mo after receiving high-dose chemotherapy/ ASCT. The patient was initially admitted to our hospital because of multiple enlarged lymph nodes. The final pathologic diagnosis, made on biopsy of a left axillary lymph node was AITL (Stage IV, Group A). Four cycles of the following chemotherapy regimen were administered: Cyclophosphamide 1.3 g, doxorubicin 86 mg, and vincristine 2 mg on day 1; prednisone 100 mg on days 1-5; and lenalidomide 25 mg on days 1-14. The interval between each cycle was 21 d. The patient received a conditioning regimen (busulfan, cyclophosphamide, and etoposide) followed by peripheral blood stem cell infusion. Unfortunately, she developed sustained fever and a low platelet count 17 d after ACST, leading to a diagnosis of HLH after ASCT. During treatment, she experienced thrombocytopenia and Pneumocystis carinii pneumonia. The patient was successfully treated with etoposide and glucocorticoids. CONCLUSION It is possible that development of HLH is related to immune reconstitution after ASCT.

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Section: Discussionmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Zhang¹,

Dou²,

Yan³

et al. 2023

World J Clin Cases

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“…I 124 -trastuzumab undergoes preferential uptake in HER2-positive tumors relative to HER2-negative ones, allowing for visualization of HER2 positivity in both primary and metastatic lesions in gastric cancer patients using PET imaging [136] (Figure 5). Yet another PET application, the aforementioned 18 F-FLT imaging, has been utilized in imaging of proliferative processes, specifically in cancer and to identify repopulation in proliferative systems such as the hematopoietic and lymphocyte systems [137][138][139][140]. Touted as a major advantage over 18 F-FDG, 18 F-FLT does not identify predictably inflammatory events in differentiated hematopoietic cells such as neutrophils [141].…”

Section: Imaging Gastrointestinal Tract Cancersmentioning

confidence: 99%

Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract

Harold

MacCuaig

Holter-Charkabarty

et al. 2022

IJMS

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Gastrointestinal disease is prevalent and broad, manifesting itself in a variety of ways, including inflammation, fibrosis, infection, and cancer. However, historically, diagnostic technologies have exhibited limitations, especially with regard to diagnostic uncertainty. Despite development of newly emerging technologies such as optoacoustic imaging, many recent advancements have focused on improving upon pre-existing modalities such as ultrasound, computed tomography, magnetic resonance imaging, and endoscopy. These advancements include utilization of machine learning models, biomarkers, new technological applications such as diffusion weighted imaging, and new techniques such as transrectal ultrasound. This review discusses assessment of disease processes using imaging strategies for the detection and monitoring of inflammation, fibrosis, and cancer in the context of gastrointestinal disease. Specifically, we include ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, graft vs. host disease, intestinal fibrosis, colorectal stricture, gastric cancer, and colorectal cancer. We address some of the most recent and promising advancements for improvement of gastrointestinal imaging, including unique discussions of such advancements with regard to imaging of fibrosis and differentiation between similar disease processes.

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Approximate Vertebral Body Instance Segmentation by PET-CT Fusion for Assessment After Hematopoietic Stem Cell Transplantation

Carson,

Hurtado,

Havlicek

et al. 2023

2023 IEEE 23rd International Conference on Bioinformatics and Bioengineering (BIBE)

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Imaging haemopoietic stem cells and microenvironment dynamics through transplantation

Cited by 4 publications

References 50 publications

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Hemophagocytic lymphohistiocytosis after autologous stem cell transplantation in angioimmunoblastic T-cell lymphoma: A case report

Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract

Approximate Vertebral Body Instance Segmentation by PET-CT Fusion for Assessment After Hematopoietic Stem Cell Transplantation

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