Imaging-Guided Radiofrequency Ablation of Solid Renal Tumors

Farrell, Michael; Charboneau, William J.; DiMarco, David S.; Chow, George K.; Zincke, Horst; Callstrom, Matthew R.; Lewis, Bradley D.; Lee, R. A.; Reading, Carl C.

doi:10.2214/ajr.180.6.1801509

Cited by 255 publications

(120 citation statements)

References 30 publications

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“…In general, RCC tumors that are Յ3 cm in diameter are ideal for ablation, with near-perfect success rates on postprocedural imaging (7-13). Most tumors smaller than 3 cm can also be treated successfully in a single session (7)(8)(9)(10)(11)(12)(13). Tumors between 3.0 and 3.5 cm in diameter can also be treated successfully with confidence, but multiple ablations and sessions may be required (7)(8)(9)(10)(11)(12)(13).…”

Section: Tumor Factorsmentioning

confidence: 99%

“…Even larger exophytic tumors are almost always treated successfully, with Ն70% requiring only a single RF session (7)(8)(9)(10)(11)(12)(13). Parenchymal tumors may be more difficult to treat, but centrally located tumors represent the largest obstacle for successful ablation.…”

Section: Tumor Factorsmentioning

confidence: 99%

“…Indeed, more than 5,000 RF ablations of focal liver tumors have been performed during the last 5 years, with Food and Drug Administration (FDA) approval being granted for this indication (1)(2)(3)(4)(5)(6). More recently, however, the clinical potential of RF ablation has greatly expanded under the blanket FDA approval for soft tissue including the treatment of kidney (7)(8)(9)(10)(11)(12)(13), breast (14), bone (15)(16)(17), lung (18), retroperitoneum (19), thyroid (20), adrenal gland (21), spleen (22), prostate (23,24), and even pheochromocytoma (25). One site in particular, the kidney, is poised for significant growth as a target for RF ablation.…”

Section: Introductionmentioning

confidence: 99%

“…One site in particular, the kidney, is poised for significant growth as a target for RF ablation. A contributing factor includes the significant increase in the incidence of renal cell carcinoma (RCC), which, when coupled with improved understanding of RF techniques, has recently led many investigators to assess the feasibility and efficacy of RF ablation for renal tumors in select patient populations (7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Review of Radiofrequency Ablation for Renal Cell Carcinoma

Hines-Peralta

Goldberg

2004

Clinical Cancer Research

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This review will discuss how minimally invasive, imageguided radiofrequency (RF) tumor ablation [i.e., coagulating tumor using short-duration heating (<15 minutes) by directly applying temperatures >50°C via needle electrodes] is being incorporated as a clinical tool for the treatment of renal cell carcinoma. RF ablation has been used to treat focal liver tumors. Potential benefits of this thermal therapy include reduced morbidity and mortality compared with standard surgical resection and the ability to treat nonsurgical patients. More recently, this technique has been introduced to treat focal renal tumors, particularly incidental lesions smaller than 3 cm in elderly patients and those with comorbid conditions. Other uses have included treatment in patients with von Hippel-Lindau syndrome and other diseases that predispose patients to multiple renal carcinomas, where renal parenchymal preservation is desired. Techniques, complications, and results will be discussed. Additionally, strategies that we are currently studying to improve RF outcomes and enable the potential treatment of larger tumors will be addressed. Most notably, recent data on increased coagulation achieved by combining RF ablation with antivascular/antiangiogenic therapies, such as arsenic trioxide, that reduce blood flow and promote heat retention are provided.

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Section: Tumor Factorsmentioning

confidence: 99%

Section: Tumor Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Review of Radiofrequency Ablation for Renal Cell Carcinoma

Hines-Peralta

Goldberg

2004

Clinical Cancer Research

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“…However, many practitioners treat T1b lesions with ablation. The main factors that help to decide whether a mass can be treated with ablation are the size and location of the tumour [22][23]. Most of the current evidence supports treatment of tumours smaller than 4 cm (T1a) [14].…”

Section: A Adammentioning

confidence: 99%

Friday 14 October 2016

2016

J Med Imag Rad Onc

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Purpose: Varicocele (abnormal dilatation of the pampiniform plexus secondary to a defect in the venous renospermatic system) is a relatively common condition, affecting 8-23% of young healthy males (1). Though often benign, it may create problems (significant pain in 14% or male factor infertility) that warrant intervention (1). Options for treatment are broadly classified into surgical or radiological (2). We aimed to determine the efficacy of radiological embolisation for the treatment of varicoceles by a single interventional radiology unit. Materials and methods: A retrospective review of all varicocele embolisation procedures performed by the interventional radiology unit at Austin Hospital (Melbourne) for the period of July 2005 to June 2015 was performed. Records and details (demographics, side, indication, duration, length of coil, complications) were obtained from electronic databases. Follow-up data was collected from the referring urologists. Results: A total of 131 varicocele embolisation procedures were performed. The majority of patients 105/131 (80%) were less than 40 years of age. Major indications were symptomatic pain (69%) or subfertility (10%). Laterality was 127/131 (97%) for left and 4/131 (3.1%) for bilateral varicoceles. Total coil length ranged from 18 to 38 mm. Procedure lengths averaged at 45mins. Complication rate was 6.1%, and mostly minor and not resulting in procedural abandonment. Complete follow-up data was obtained for 83patients only. Of these, recurrence occurred in only five patients (6.0%). Conclusions: Our study demonstrates that radiological embolisation is an effective modality for the treatment of varicoceles. Our single centre experience demonstrates comparable complication and recurrence rates of radiological embolisation versus the surgical treatment options (3). Given radiological embolisation is a day procedure with a reasonably short procedure time; our findings make it an effective option comparable to surgery. Objective / Introduction: Radiography of the immature skeleton is complex for junior doctors and students due to physes and ossification centers. Knowledge of normal radiographic characteristics is important to interpretation, which form the majority of xray studies of the paediatric population. Books and image based resources such as Keats Atlas of Normal Variants are cumbersome as an introductory resource, and a video/timelapse approach to normal skeletal development would condense the knowledge to a more accessible form. Project objective is to improve JMO proficiency in reading paediatric radiographs, including familiarity with the order of appearance of ossification centers, and improved fracture detection accuracy. Methods and materials:To demonstrate feasibility, a test timelapse was completed for the pelvis and proximal femur for 0-10 years of age. Anonymised radiographs were obtained from the local radiology department PACS. Images were aligned and stacked in a video editor, and annotated the order of appearance of ossification centres and physeal...

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