Imaging-guided photoacoustic drug release and synergistic chemo-photoacoustic therapy with paclitaxel-containing nanoparticles

Zhong, Junping; Yang, Sihua; Wen, Liewei; Xing, Da

doi:10.1016/j.jconrel.2016.02.010

Cited by 43 publications

(33 citation statements)

References 50 publications

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“…Nowadays, multimodal imaging that combines various imaging modalities to provide complementary information has demonstrated obvious advantages over single-modal imaging, promising for cancer diagnosis and prognostic evaluation 1-4. On the other hand, combination therapy in which different treatment strategies are applied via a synergistic manner has become an important trend in the development of cancer treatment 5-7.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Zhao¹,

Chao²,

Liu³

et al. 2016

Theranostics

113

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Single-walled carbon nanotubes (SWNTs) with various unique properties have attracted great attention in cancer theranostics. Herein, SWNTs are coated with a shell of polydopamine (PDA), which is further modified by polyethylene glycol (PEG). The PDA shell in the obtained SWNT@PDA-PEG could chelate Mn2+, which together with metallic nanoparticulate impurities anchored on SWNTs offer enhanced both T1 and T2 contrasts under magnetic resonance (MR) imaging. Meanwhile, also utilizing the PDA shell, radionuclide 131I could be easily labeled onto SWNT@PDA-PEG, enabling nuclear imaging and radioisotope cancer therapy. As revealed by MR & gamma imaging, efficient tumor accumulation of SWNT@PDA-131I-PEG is observed after systemic administration into mice. By further utilizing the strong near-infarared (NIR) absorbance of SWNTs, NIR-triggered photothermal therapy in combination with 131I-based radioisotope therapy is realized in our animal experiments, in which a remarkable synergistic antitumor therapeutic effect is observed compared to monotherapies. Our work not only presents a new type of theranostic nanoplatform based on SWNTs, but also suggests the promise of PDA coating as a general approach to modify nano-agents and endow them with highly integrated functionalities.

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Section: Introductionmentioning

confidence: 99%

Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Zhao¹,

Chao²,

Liu³

et al. 2016

Theranostics

113

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“…This study suggests that, beyond ultrasounds, other physical forces can be used to trigger taxane release form NBs. Accordingly, very recently, Zhong et al demonstrated, very recently, that upon pulsed laser irradiation, paclitaxel loaded nanoparticles induced apoptosis in prostate cancer cells and inhibited tumor growth in vivo [32]. …”

Section: Discussionmentioning

confidence: 99%

Targeting Taxanes to Castration-Resistant Prostate Cancer Cells by Nanobubbles and Extracorporeal Shock Waves

et al. 2016

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To target taxanes to castration-resistant prostate cancer cells, glycol-chitosan nanobubbles loaded with paclitaxel and docetaxel were constructed. The loaded nanobubbles were then combined with Extracorporeal Shock Waves, acoustic waves widely used in urology and orthopedics, with no side effects. Nanobubbles, with an average diameter of 353.3 ± 15.5 nm, entered two different castration-resistant prostate cancer cells (PC3 and DU145) as demonstrated by flow cytometry and immunofluorescence. The shock waves applied increased the amount of intracellular nanobubbles. Loading nanobubbles with paclitaxel and docetaxel and combining them with shock waves generated the highest cytotoxic effects, resulting in a paclitaxel GI50 reduction of about 55% and in a docetaxel GI50 reduction of about 45% respectively. Combined treatment also affected cell migration. Paclitaxel-loaded nanobubbles and shock waves reduced cell migration by more than 85% with respect to paclitaxel alone; whereas docetaxel-loaded nanobubbles and shock waves reduced cell migration by more than 82% with respect to docetaxel alone. The present data suggest that nanobubbles can act as a stable taxane reservoir in castration-resistant prostate cancer cells and shock waves can further increase drug release from nanobubbles leading to higher cytotoxic and anti-migration effect.

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“…The researchers found that the PA signal was enhanced due to the vaporization of perfluorocarbon as compared to the signal from Au NRs that were produced thermal expansion only. Taking advantage of this design, the Xing group loaded paclitaxel and Au NRs into perfluorohexane nanodroplets for PAI-guided chemotherapy and additionally functionalized the nanodroplets with folic acid for tumor targeting [65]. Upon application of a pulsed laser, the nanodroplets were rapidly destroyed due to the vaporization of perfluorohexane, resulting in rapid drug release.…”

Section: Inorganic Nanomaterials-based Photoacoustic Therapymentioning

confidence: 99%

Photoacoustic Drug Delivery

Zhang

Kahkoska

et al. 2017

Sensors

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Photoacoustic (PA) technology holds great potential in clinical translation as a new non-invasive bioimaging modality. In contrast to conventional optical imaging, PA imaging (PAI) enables higher resolution imaging with deeper imaging depth. Besides applications for diagnosis, PA has also been extended to theranostic applications. The guidance of PAI facilitates remotely controlled drug delivery. This review focuses on the recent development of PAI-mediated drug delivery systems. We provide an overview of the design of different PAI agents for drug delivery. The challenges and further opportunities regarding PA therapy are also discussed.

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Imaging-guided photoacoustic drug release and synergistic chemo-photoacoustic therapy with paclitaxel-containing nanoparticles

Cited by 43 publications

References 50 publications

Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Targeting Taxanes to Castration-Resistant Prostate Cancer Cells by Nanobubbles and Extracorporeal Shock Waves

Photoacoustic Drug Delivery

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