Imaging findings of spinal brown tumors: a rare but important cause of pathologic fracture and spinal cord compression

Colucci, Philip G.; Schweitzer, Andrew D.; Saab, Jad; Lavi, Ehud; Chazen, J. Levi

doi:10.1016/j.clinimag.2015.06.002

Cited by 7 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skeletal X-rays remain mostly unremarkable in milder primary hyperparathyroidism; however, in advanced disease, characteristic changes such as demineralization, subperiosteal erosion, and terminal resorption in the phalanges can occur. Clinically, OFC can also be associated with pathological fractures (7). Bone involvement in hyperparathyroidism has shown a significant decrease in incidence over the past decades (from 80% to as low as 15%).…”

Section: Discussionmentioning

confidence: 99%

Investigating Unexpected Shortening of Height of A Middle-Aged Woman: A Case Report

Muhtasim,

Persi,

Khan

et al. 2023

Bangladesh J. Nuclear Med.

View full text Add to dashboard Cite

Osteitis fibrosa cystica (OFC) is a late sequela of untreated hyperparathyroidism caused by the autonomous secretion of parathyroid hormone (PTH). It is characterized by bone pain, skeletal deformities, and pathological fractures. OFC is caused by hypersecretion of PTH, leading to demineralization of bone and pathological fractures. We report a case of unusual presentation of OFC in a middle aged woman who noticed gradual shortening of her height within a particular period of time. Apart from height reduction, the patient had weight loss and pain in different parts of the body for over a decade. Despite being treated with analgesics and steroids initially, there was no significant improvement in her condition. Treatment history included surgical reduction of right elbow fracture and empirical anti-tubercular drug twice as there was a suspicion of disseminated tuberculosis. The patient developed lytic changes, skeletal deformities, and osteoporosis, and was diagnosed with a solitary parathyroid adenoma on the right side. Bangladesh J. Nuclear Med. 26(1): 58-61, 2023

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating Unexpected Shortening of Height of A Middle-Aged Woman: A Case Report

Muhtasim,

Persi,

Khan

et al. 2023

Bangladesh J. Nuclear Med.

View full text Add to dashboard Cite

show abstract

“…The most typical skeletal manifestation of hyperparathyroidism were loss of cortical bone and trabecular remodeling due to osteoclast activation. OFC can be associated clinically with bone fractures, skeletal deformities and bone pain [6]. At present, osteitis brosa cystica, though rare, was easily misdiagnosed.…”

Section: Introductionmentioning

confidence: 99%

A Patient With Femoral Osteitis Fibrosa Cystica Due To Hyperparathyroidism: A Case Report

Yang

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Osteitis fibrosa cystica is a rare benign, lytic bone lesion attributed to hyperparathyroidism. The high level of parathyroid hormone cause rapid bone loss.Case presentation: The patient is a 50-year-old male complaining of severe sustained pain of the right knee joint. Imaging studies were suspicious for a benign tumor of the right distal femur. Biopsy under CT guidance showed numerous osteoclast aggregation and hemosiderin deposition around the bone trabeculae. Blood tests disclosed significantly elevated parathyroid hormone, serum calcium, serum alkaline phosphatase. Parathyroid ultrasonography and CT scan showed a solid mass in front of the trachea at the thoracic entrance plane. After resection of the mass, the clinical symptoms were relieved and the radiological findings were significantly improved, which further confirmed the diagnosis.Conclusions: Metabolic diseases-associated bone lesions require a comprehensive diagnosis of multiple inspection items.An interprofessional team approach to the diagnosis and treatment of Osteitis fibrosa cystica will provide the best outcome.

show abstract

“…The most typical skeletal manifestation of hyperparathyroidism were loss of cortical bone and trabecular remodeling due to osteoclast activation. OFC can be associated clinically with bone fractures, skeletal deformities and bone pain [ 6 ]. At present, osteitis fibrosa cystica, though rare, was easily misdiagnosed.…”

Section: Introductionmentioning

confidence: 99%

A patient with femoral osteitis fibrosa cystica mimicking bone neoplasm: a case report

Yang

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Osteitis fibrosa cystica is a rare, benign and osteolytic lesion attributed to hyperparathyroidism. The high level of parathyroid hormone cause rapid bone loss. Case presentation The patient is a 50-year-old male complaining of severe and persistent pain in the right knee joint. Imaging studies were suspicious for a benign tumor in the right distal femur. Biopsy under CT guidance showed numerous osteoclast aggregation and hemosiderin deposition around the bone trabeculae. Blood tests disclosed significantly elevated parathyroid hormone, serum calcium, serum alkaline phosphatase. Parathyroid ultrasonography and CT scan showed a solid mass in front of the trachea at the thoracic entrance plane. After resection of the mass, the clinical symptoms were relieved and the radiological results were significantly improved, which further confirmed the diagnosis. Conclusions Metabolic diseases-associated bone lesions require a comprehensive diagnosis of multiple inspection items. An interprofessional team approach to the diagnosis and treatment of osteitis fibrosa cystica will provide the best outcome.

show abstract

Imaging findings of spinal brown tumors: a rare but important cause of pathologic fracture and spinal cord compression

Cited by 7 publications

References 5 publications

Investigating Unexpected Shortening of Height of A Middle-Aged Woman: A Case Report

Investigating Unexpected Shortening of Height of A Middle-Aged Woman: A Case Report

A Patient With Femoral Osteitis Fibrosa Cystica Due To Hyperparathyroidism: A Case Report

A patient with femoral osteitis fibrosa cystica mimicking bone neoplasm: a case report

Contact Info

Product

Resources

About