Imaging findings of ovarian leiomyosarcoma with histopathologic correlations

Fischetti, Aldo; Rutigliani, Mariangela; Romano, Nicola; Marinaro, E.; Puppo, Cristina; Gorlero, Franco; Melani, E.; Rollandi, Gian Andrea

doi:10.1016/j.ejogrb.2019.02.038

Cited by 3 publications

(11 citation statements)

References 3 publications

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“…Most of the tumors are >10 cm in diameter, and the cut surface is fish‐like, accompanied by hemorrhagic necrosis and cystic degeneration 12 . The diagnosis of POLMS mainly depends on ultrasound and MRI findings, and pathological immunohistochemistry 1,6,12,13 . The tumor cells are arranged in a spiral, woven, and fence‐like shape, with multinucleated giant cells, medium‐severe atypia, and ≥10 mitotic figures/hpf 6,12 .…”

Section: Discussionmentioning

confidence: 99%

“…12 The diagnosis of POLMS mainly depends on ultrasound and MRI findings, and pathological immunohistochemistry. 1,6,12,13 The tumor cells are arranged in a spiral, woven, and fence-like shape, with multinucleated giant cells, medium-severe atypia, and ≥10 mitotic figures/hpf. 6,12 Desmin, SMA, vimentin, P53, and hcaldesmon are diffusely and strongly positive based on immunohistochemistry staining.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent primary ovarian leiomyosarcoma preconception, pregnancy, delivery, and puerperal management: A case report and literature review

Fan

Wang

et al. 2022

J of Obstet and Gynaecol

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A primary ovarian leiomyosarcoma (POLMS) is a rare malignant tumor of the ovary. Herein, we report a patient with an early‐stage POLMS who underwent unilateral adnexectomy in our department with a subsequent pregnancy, delivery, and tumor recurrence. In this case, the patient was a 29‐year‐old female with a complaint of abdominal distention who underwent a right adnexectomy for a solid tumor in the right ovary. The pathological diagnosis was a stage IA leiomyosarcoma of the right ovary. One month later, a recurrence in the left ovary tumor was diagnosed. The patient did not agree to further treatment. She subsequently achieved a spontaneous pregnancy and had an uneventful pregnancy and delivery at term. During the puerperium, she underwent radical surgery and chemotherapy with the recommended follow‐up evaluation. The literature review shows the pathogenesis of POLMS has not been established. There are no specific tumor markers, and it is difficult to distinguish the nature and origin of the tumor with imaging modalities, thus, early diagnosis is difficult. The malignancy rate is high, and the prognosis of advanced tumors is poor. To properly counsel patients to optimize treatment, more reports of cases, the disease course, treatments, and outcomes are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrent primary ovarian leiomyosarcoma preconception, pregnancy, delivery, and puerperal management: A case report and literature review

Fan

Wang

et al. 2022

J of Obstet and Gynaecol

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“…POLMS was treated by surgical resection in 76/80 (95%) patients [1,2,[4][5][6]9,10,15,16,19,20,22,[25][26][27][28][29][30][31][32][33]. A total of 34/80 (42.5%) patients received surgery without lymphadenectomy [2,9,13,14,16,19,20,22,26,[28][29][30][34][35][36][37]39,40,43,[57][58][59][60]64,65]…”

Section: Surgerymentioning

confidence: 99%

“…A total of 52/89 (58.4%) patients were stage I, 8/89 (9%) patients were stage II, 25/89 (28%) patients were stage III, and 4/89 (4.6%) patients were stage IV. Mitotic count was reported in 81/113 (71.7%) patients [1,[4][5][6]9,[13][14][15][16][18][19][20]22,23,25,26,28,29,[31][32][33][34][35][36][37][38][39][40][41][43][44][45][46][47]49,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65], and the mean number of mitoses w...…”

Section: Risk Factorsmentioning

confidence: 99%

“…CD68 testing was available in 3/113 (2.6%) patients [10,16,46] and was positive in 2/3 (66.7%) patients [16,27] and negative in 1/3 (33.3%) patients [10]. Ki-67 testing was available in 12/113 (10.6%) patients [1,5,14,16,38,45,51,53,60,62,64,67] and was negative in 2/12 (16.7%) patients [14,64] and positive in 10/12 (83.3%) patients [1,5,16,38,45,51,53,60,62,67], with mean value of 26.3% and range between 10% and 50%.…”

Section: Immunohistochemistrymentioning

confidence: 99%

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Primary Ovarian Leiomyosarcoma Is a Very Rare Entity: A Narrative Review of the Literature

Mandato

Torricelli

Mastrofilippo

et al. 2023

Cancers

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Background: Primary ovarian leiomyosarcoma is a very rare malignancy characterized by unclear management and poor survival. We reviewed all the cases of primary ovarian leiomyosarcoma to identify prognostic factors and the best treatment. Methods: We collected and analyzed the articles published in the English literature regarding primary ovarian leiomyosarcoma from January 1951 to September 2022, using PubMed research. Clinical and pathological characteristics, different treatments and outcomes were analyzed. Results: 113 cases of primary ovarian leiomyosarcoma were included. Most patients received surgical resection, associated with lymphadenectomy in 12.5% of cases. About 40% of patients received chemotherapy. Follow-up information was available for 100/113 (88.5%) patients. Stage and mitotic count were confirmed to affect survival, and lymphadenectomy and chemotherapy were associated with a better survival rate. A total of 43.4% of patients relapsed, and their mean disease-free survival was 12.5 months. Conclusions: Primary ovarian leiomyosarcomas are more common in women in their 50s (mean age 53 years). Most of them are at an early stage at presentation. Advanced stage and mitotic count showed a detrimental effect on survival. Surgical excision associated with lymphadenectomy and chemotherapy are associated with increased survival. An international registry could help collect clear and reliable data to standardize the diagnosis and treatment.

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Mesenchymal Tumors of the Ovary

Nucci,

Baniak

2023

Essentials of Diagnostic Gynecological Pathology

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Imaging findings of ovarian leiomyosarcoma with histopathologic correlations

Cited by 3 publications

References 3 publications

Recurrent primary ovarian leiomyosarcoma preconception, pregnancy, delivery, and puerperal management: A case report and literature review

Recurrent primary ovarian leiomyosarcoma preconception, pregnancy, delivery, and puerperal management: A case report and literature review

Primary Ovarian Leiomyosarcoma Is a Very Rare Entity: A Narrative Review of the Literature

Mesenchymal Tumors of the Ovary

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