Imaging findings of gastric plexiform fibromyxoma with a cystic change

Yang, Ming; Zhao, Zhenhua; Yang, Jianfeng; Chen, Bing; Shen, Xizhong; Wei, Jianguo; Wang, Boyin

doi:10.1097/md.0000000000008967

Cited by 14 publications

(15 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is consistent with another recently reported case of a histologically confirmed GPF with imaging findings of a cystic-solid well-circumscribed extraluminal mass located in the posterior wall of the gastric upper body. 7 Reportedly, no KIT or platelet-derived growth factor receptor alpha (PDGFRa) mutations were identified in the three examined cases. 3 A recent study also mentioned that the gene glioma-associated oncogene homologue 1 (GLI1) may be present in a subgroup of these tumors.…”

Section: Discussionmentioning

confidence: 94%

“…Gastric plexiform fibromyxoma (GPF) is a rare benign mesenchymal neoplasm usually arising in the gastric antrum and clinically manifesting similar to a GIST. Only a few cases of GPF have been reported since the first case described in 2007 by Takahashi et al [2][3][4][5][6][7] The characteristic histologic features of GPF include multiple plexiform nodules containing paucicellular to moderately cellular myxoid, collagenous, or fibromyxoid stromal components. 5 In contrast to GIST, GPF is negative for C-Kit/CD117, Dog1, and CD34.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls

Lai

Kresak

Cao

et al. 2019

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls

Lai

Kresak

Cao

et al. 2019

Journal of Surgical Research

View full text Add to dashboard Cite

“…Five cases in 4 reports were excluded because of incompatible immunohistochemistry results, such as positive for CD34 or S100. [4–7] Including 79 PF cases in 41 reports and 1 PF case treated in our center, a total of 80 PF cases (of which 70 were adult PF and 10 were pediatric PF cases) were included in this review; they are listed in Table 1 . [2,6,8–46] There was complete agreement between the review authors assessing the reports.…”

Section: Resultsmentioning

confidence: 99%

Pediatric plexiform fibromyxoma

Fukazawa¹,

Koga²,

Hiroshige³

et al. 2019

Medicine

View full text Add to dashboard Cite

Background:Plexiform fibromyxoma (PF) is a rare gastric mesenchymal tumor, with approximately 80 cases reported to date. Gastrointestinal stromal tumor, the most common primary mesenchymal tumor of the stomach, shows different biological and clinical characteristics between adult and pediatric patients.Objectives:This systematic literature review was conducted to elucidate the pathological and clinical features of pediatric PF compared to adult PF.Methods:MEDLINE (1948 to March 2018) and EMBASE (1947 to March 2018) were searched, and all English articles that reported clinical data on PF patients were identified. Two authors independently reviewed the articles and extracted data to assess immunohistochemistry, sex, chief complaint, tumor size, tumor-related mortality, and tumor recurrence and metastasis.Results:A total of 41 reports with 80 PF patients (of whom 70 were adult PF and 10 were pediatric PF patients) confirmed by histological and immunohistochemical findings were included. Of a total of 80 tumors, 62 (78%) were located in the gastric antrum, 42 (65%) presented with ulceration, and 48 (74%) were resected by partial gastrectomy. Median tumor size of the resected specimen was larger in pediatric PF than in adult PF cases (5.3 cm vs 4.0 cm, P = .036). However, there was no difference between pediatric and adult PFs in immunohistochemical expression, sex predominance, chief complaint, tumor-related mortality, and tumor recurrence and metastasis during the follow-up periods.Conclusion:Other than increased tumor growth in pediatric PFs, PF is a single disease entity with similar pathological features and benign clinical behavior regardless of onset age.

show abstract

“…Data regarding the radiologic features of PF are limited in the literature due to its rarity[ 28 ]. Imaging findings may be suggestive of another mesenchymal tumor such as GIST[ 22 ].…”

Section: Imagingmentioning

confidence: 99%

Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis

Arslan

et al. 2021

WJGO

View full text Add to dashboard Cite

Plexiform fibromyxoma (PF) is a very rare mesenchymal neoplasm of the stomach that was first described in 2007 and was officially recognized as a subtype of gastric mesenchymal neoplasm by World Health Organization (WHO) in 2010. Histologically, PF is characterized by a plexiform growth of bland spindle to ovoid cells embedded in a myxoid stroma that is rich in small vessels. The lesion is usually paucicellular. While mucosal and vascular invasion have been documented, no metastasis or malignant transformation has been reported. Its pathogenesis is largely unknown and defining molecular alterations are not currently available. There are other mesenchymal tumors arising in the gastrointestinal tract that need to be differentiated from PF given their differing biologic behaviors and malignant potential. Histologic mimics with spindle cells include gastrointestinal stromal tumor, smooth muscle tumor, and nerve sheath tumor. Histologic mimics with myxoid stroma include myxoma and aggressive angiomyxoma. Molecular alterations that have been described in a subset of PF may be seen in gastroblastoma and malignant epithelioid tumor with glioma-associated oncogene homologue 1 ( GLI1 ) rearrangement. The recent increase in publications on PF reflects growing recognition of this entity with expansion of clinical and pathologic findings in these cases. Herein we provide a review of PF in comparison to other mesenchymal tumors with histologic and molecular resemblance to raise the awareness of this enigmatic neoplasm. Also, we highlight the challenges pathologists face when the sample is small, or such rare entity is encountered intraoperatively.

show abstract

Imaging findings of gastric plexiform fibromyxoma with a cystic change

Cited by 14 publications

References 22 publications

Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls

Gastric Plexiform Fibromyxoma: A Great Mimic of Gastrointestinal Stromal Tumor (GIST) and Diagnostic Pitfalls

Pediatric plexiform fibromyxoma

Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis

Contact Info

Product

Resources

About