Imaging findings of a primary bladder maltoma

Maninderpal, K G; Amir, Fatima; Azad, Hooman; Mun, Kein Seong

doi:10.1259/bjr/66130737

Cited by 16 publications

(29 citation statements)

References 6 publications

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“…[ 1 2 ] Primary lymphomas of the urinary bladder are extremely rare, representing 0.2% of all extranodal lymphomas and <1% of all bladder tumors. [ 3 ] As of 2007, a little over 100 cases have been reported since the initial discovery by Eve and Chaffey in 1885. [ 4 5 ]…”

Section: Introductionmentioning

confidence: 99%

Primary bladder lymphoma, diffuse large B-cell type: Case report and literature review of 26 cases

et al. 2015

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Primary lymphoma of the urinary bladder is exceedingly rare, representing 0.2% of all extranodal non-Hodgkin's lymphoma. Although Matsuno et al. and others state the most common type is mucosa-associated lymphoid tissue (MALT) lymphoma, 20% of all the primary lymphomas of the urinary bladder are considered to be high grade neoplasms; the majority being diffuse large B-cell lymphoma (DLBCL). This is a case report of a 48-year-old man that presented with hematuria, frequency, nocturia, and flank pain that was found to have high grade DLBCL. Twenty-six other cases of both low and high grade primary bladder lymphomas were selected in order to provide a thorough comparison of different treatment modalities. Of the cases reviewed, bladder lymphoma was more common in females (2:1). The average age at diagnosis was 63.9 years old (low grade: 68.7 years old, high grade: 58.8 years old). The most common low-grade neoplasm was MALT lymphoma (85.7%). For the low-grade malignancies, the most successful treatments were simple therapies (2 transurethral resection of a bladder tumour [TURBT], 1 antibiotics), solitary chemotherapy, and combination TURBT/chemo; all 3 of which achieved 100% clinical remission (CR) in the cases reviewed. The most common high grade neoplasm was DLBCL (76.9%). The most successful therapies used to treat high grade lesions were solitary chemotherapy (cyclophosphamide, duanorubacin, vincristine, prednisolone [CHOP] or ritoximab, CHOP [R-CHOP]) and combination therapies (2 radiation/CHOP, 2 surgery/CHOP). In the agreement with the current literature, this review has shown that simple therapies (TURBT) are equally as effective as aggressive treatments (chemotherapy, radiation) and should therefore be used as first line treatment in low grade tumors. For high grade malignancies, chemotherapy (R-CHOP or CHOP) alone or combination therapy (CHOP/surgery or CHOP/radiation) is recommended.

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Section: Introductionmentioning

confidence: 99%

Primary bladder lymphoma, diffuse large B-cell type: Case report and literature review of 26 cases

et al. 2015

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“…Bladder lymphoma was first described in 1985 by Eve and Chaffey [2]. Just over 100 cases have been reported since.…”

Section: Discussionmentioning

confidence: 99%

“…Just over 100 cases have been reported since. Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue type (MALT-type lymphoma) of the urinary bladder, first described in 1990, is the most common primary bladder lymphoma [2,4,5]. On histology most, cases are low-grade lymphomas [6].…”

Section: Discussionmentioning

confidence: 99%

“…It should eliminate the presence of any other lesions to confirm the primary origin of the bladder lymphoma. It must include hole body PET-scan and bone marrow biopsy [2,27].…”

Section: Discussionmentioning

confidence: 99%

“…It constitutes 5% of the nonurothelial tumour of the urinary tract [1] Primary isolated bladder lymphoma represents only 0.2% of all extranodal Non-Hodgkin-Lymphoma and less than 1% of all bladder tumours [2,3]. Of primary lymphomas of the bladder, mucosa associated lymphoid tissue lymphoma, or MALT, is the most prevalent histological subtype.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Case Report about a Primary Bladder Lymphoma

Combaz¹,

Kühn²

2017

Int Arch Urol Complic

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Primary isolated bladder lymphoma represents around 0.2% of all extranodal Non-Hodgkin-Lymphoma and less than 1% of all bladder tumours. Clinical representation may be unspecific and correct diagnosis is essential for the appropriate treatment. We expose the case of a patient with a primary B-cell bladder lymphoma with normal cystoscopy. Case report:A 67-year-old patient presented with lower urinary tract infections, overactive bladder with urinary incontinence as well as haematuria susceptible for bladder carcinoma. Urine sediment, cytologie, abdominal-and kidney ultrasound as well as a CT scan did not lead to a conclusive diagnosis. Surprisingly, cystoscopy did not demonstrate any tumourous lesions and urine cytology revealed free of malignant cells. Cold four-quadrant cut biopsies finally did reveal the presence of a primary B-cell lymphoma. After a four weeks' antibody treatment of Rituximab (Mabthera) the patient showed subjective improvement and lower urinary tract symptoms disappeared. Clinical follow-up as well as repeat cystoscopic biopsies were undertaken every six months. After a follow-up period of nearly three years the patient is still in complete remission. Urinary tract infections and incontinence as well as OAB symptoms disappeared entirely.Discussion: Haematuria was the main clinical finding in the current case of primary bladder lymphoma. Uneventful radiologic examinations lead to the necessity of bladder biopsies without any macroscopic pathologic findings. We present the exceedingly rare case of a primary bladder lymphoma without any characteristic lesions in the bladder lumen. For this reason, cystoscopic four quadrant biopsies should be used largely. Biopsies are essential leading to the correct diagnosis and finally successful treatment. Single antibody therapy with Rituximab is an option in selected cases as the one presented and can be used as un therapeutic option.

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Bladder Cancer

Woo

Cho

2018

Bladder Cancer

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Imaging findings of a primary bladder maltoma

Cited by 16 publications

References 6 publications

Primary bladder lymphoma, diffuse large B-cell type: Case report and literature review of 26 cases

Primary bladder lymphoma, diffuse large B-cell type: Case report and literature review of 26 cases

Case Report about a Primary Bladder Lymphoma

Bladder Cancer

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