Imaging findings in primary adenosquamous carcinoma of the liver: a case report

Yokota, Hajime; Matoba, Munetaka; Tonami, Hisao; Hasegawa, Taisuke; Saitô, Hitoshi; Kurose, Nozomu

doi:10.1016/j.clinimag.2007.01.007

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…The imaging findings of primary SCC and ASC patients in our study were almost the same with previous reports, and they also found most of the MRI of primary hepatic SCC and ASC presented a low signal on T1WI image and high signal on T2WI image [ 33 ]. Someone detected that the ASC had a performance of high-signal T1WI image, which might relate to its solid-cystic structure and central necrosis [ 30 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma

et al. 2015

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BackgroundThere are still several controversies and ambiguities in the aspects of primary hepatic squamous cell carcinoma and primary hepatic adenosquamous carcinoma. To further clarify the specific features of these two infrequent diseases and provide beneficial propose for clinical decision, we did this retrospective study.MethodsWe reviewed the clinical features and outcomes of three primary hepatic squamous cell carcinoma (SCC) patients and six primary hepatic adenosquamous carcinoma (ASC) patients from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital in China. Meanwhile, 40 hepatocellular carcinoma (HCC) patients and 26 metastatic hepatic SCC or ASC patients who were hospitalized in the same period were also reviewed to make a comparison. In order to find out the definite survival information of SCC and ASC patients, 30 previous studies containing 37 primary hepatic SCC (16) and ASC (21) patients were reviewed, and their information of survival was analyzed together with the included patients in our hospital.ResultsSerum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9). On the pathologic performance, primary SCC/ASC tumor was rarely accompanied with tumor capsule. They presented peripheral hepatic lymph node metastasis more likely and showed low proportion of microvascular invasion. The median survival time of primary hepatic SCC/ASC patients after liver resection (LR) was 15 months. And the 1-, 3-, 5-year survival rates after LR were 60%, 24%, and 12%, respectively. Significant difference was not discovered when SCC and ASC patients were compared with HCC patients (P = 0.294). The median survival time after LR for primary SCC and ASC patients was respectively 23 months and 13 months.ConclusionsThe comprehensive application of some clinical characteristics, histopathologic features, and imaging findings may be useful for us in making definite diagnoses for primary hepatic SCC and ASC patients preoperatively. And the treatment of liver resection was effective for those patients who met the selection criteria for liver resection.

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Section: Discussionmentioning

confidence: 99%

The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma

et al. 2015

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“…These results are consistent with the poor prognosis of primary hepatic ASC patients after surgery. The clinical information of 19 patients (surgery followed by postoperative adjuvant chemotherapy, surgery and chemotherapy after recurrence, chemotherapy and conversion surgery, systemic chemotherapy alone, and chemoradiation) treated with chemotherapy, including the details of the drugs used is summarized in Table 2 [ 17 , 19 – 21 , 27 – 29 , 36 , 37 , 39 , 41 , 45 , 46 ]. In patients who received postoperative adjuvant chemotherapy, tumor recurrence was prevented in five out of seven patients.…”

Section: Discussionmentioning

confidence: 99%

Unresectable primary hepatic adenosquamous carcinoma successfully treated with systemic and transcatheter hepatic arterial injection chemotherapies followed by conversion surgery: a case report and literature review

et al. 2021

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Background Primary hepatic adenosquamous carcinoma (ASC) is a type of tumor that has the features of both adenocarcinoma and squamous cell carcinoma (SCC). The prognosis for patients with ASC is poor, as the chemotherapy has been ineffective so far. Case presentation Here, we report a case of a 62-year-old male patient who presented with high fever. The tumor marker levels were high, and abdominal dynamic computed tomography showed a liver tumor and distant lymph node metastases. Upon further investigation, needle biopsy of the liver tumor showed a primary hepatic SCC. Because the SCC was unresectable, the patient was treated with tegafur/gimeracil/oteracil (S-1) and transcatheter hepatic arterial injection (TAI) of cisplatin. After chemotherapy, a surgical resection performed on the remaining liver tumor, made the patient cancer-free. After the operation, the liver tumor was confirmed as primary hepatic ASC. Subsequently, the patient was administered postoperative adjuvant chemotherapy, which prevented its recurrence. Conclusions Due to the lack of an effective treatment for primary hepatic ASC, its prognosis is poor. Here, we suggest that a chemotherapy combination of 5-fluorouracil (S-1) and cisplatin along with conversion surgery might be an effective way for treating primary hepatic ASC. Our experience from this case shall be valuable to clinicians around the world involved in the treatment of primary hepatic ASC.

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“…Imaging features are shared with other carcinomas developing in the extrahepatic biliary tract (Yokota et al 2007;Kim et al 2009). In CT scans, the lesion was diagnosed as bile duct cancer of the periductal infiltrative type seen as a segmentally thickened ductal wall encircling the lumen, with delayed enhancement.…”

Section: Clinical and Imaging Presentationmentioning

confidence: 98%

Carcinomas with a Squamous Cell Lineage

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Imaging findings in primary adenosquamous carcinoma of the liver: a case report

Cited by 12 publications

References 9 publications

The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma

The comparison of surgical patients with primary hepatic squamous cell carcinoma or adenosquamous carcinoma and surgical patients with hepatocellular carcinoma

Unresectable primary hepatic adenosquamous carcinoma successfully treated with systemic and transcatheter hepatic arterial injection chemotherapies followed by conversion surgery: a case report and literature review

Carcinomas with a Squamous Cell Lineage

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