Imaging fiber microarray fluorescent ion sensors based on bulk optode microspheres

Wyglądacz, Katarzyna; Bakker, Eric

doi:10.1016/j.aca.2004.10.071

Cited by 43 publications

(46 citation statements)

References 43 publications

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“…303 They transmit coherent images enabling combined imaging and sensing, relating the responses monitored by the sensor to observable physical changes. The Walt and Bakker groups have developed high-density microarray optical sensors for explosive-like vapors, 3,83,299 metal ions, 304 and bio-sensors. 305,306 In a similar approach McDevitt and coworkers used polystyrene-poly(ethylene glycol) and agarose microspheres arranged in micromachined cavities etched in silicon wafers for analysis of beverages.…”

Section: Nanosensorsmentioning

confidence: 99%

Design of fluorescent materials for chemical sensing

2007

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There is an enormous demand for chemical sensors for many areas and disciplines. High sensitivity and ease of operation are two main issues for sensor development. Fluorescence techniques can easily fulfill these requirements and therefore fluorescent-based sensors appear as one of the most promising candidates for chemical sensing. However, the development of sensors is not trivial; material science, molecular recognition and device implementation are some of the aspects that play a role in the design of sensors. The development of fluorescent sensing materials is increasingly captivating the attention of the scientists because its implementation as a truly sensory system is straightforward. This critical review shows the use of polymers, sol-gels, mesoporous materials, surfactant aggregates, quantum dots, and glass or gold surfaces, combined with different chemical approaches for the development of fluorescent sensing materials. Representative examples have been selected and they are commented here.

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Section: Nanosensorsmentioning

confidence: 99%

Design of fluorescent materials for chemical sensing

2007

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“…This has been proven by numerous research on polyacrylate based ion-selective electrodes [e.g. 17,18] as well as on polymeric microspheres [4,6,16].…”

Section: Resultsmentioning

confidence: 97%

“…Incorporation of molecules into the polymeric microspheres, in principle, can be achieved either during polymerization [4,6] or afterwards by absorption of molecules to ready spheres, e.g. during microspheres contact with mixed water/THF based solution containing the molecule of choice [15,16].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Enzyme Substrates Protective Encapsulation within Polymeric Microspheres

Zajda¹,

Jastrzębska²,

Olszyna³

et al. 2013

AJAC

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Determination of enzymes activity is an important task of analytical and biomedical oriented fluorimetry. Despite of a long track record of application, there is still some room for improvements in this field. In the case of hydrolases, spontaneous decomposition of substrate leads to substantial errors in determination of enzyme activity. An innovative and effective approach is proposed allowing protection of enzyme substrate within the lipophilic moiety of polyacrylate microspheres. It is shown that the introduction of substrate into microspheres is not only an effective method of prevention of unwanted spontaneous process, but also does not disturb the availability of substrate for enzymatic hydrolysis. The effect of presence of proteins in the sample on fluorimetric responses was studied. In contrary to previous studies related to application of lipophilic polymers in biomedical analysis, it is shown that the presence of bovine serum albumins enhances the sensitivity of fluorimetric determination. It is shown that this surprising effect is related to adsorption of proteins on the microspheres surface and change of surface charge of polymer.

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“…[56] This general bead based sensing approach was extended to the use of imaging arrays in which the beads were dropped into etched wells that can be individually addressed with fluorescence microscopy. [58] The volume of a 10-mm microparticle sensors is about 1 picoliter and hence drastically smaller relative to their traditional thick film counterparts. [59] A net extraction of even 1 millimolar concentration into such a particle corresponds therefore to just a quantity of about 1 fmol.…”

Section: Optical Ion Sensorsmentioning

confidence: 99%

Advancing Membrane Electrodes and Optical Ion Sensors

Bakker

Crespo²,

Grygołowicz‐Pawlak³

et al. 2011

Chimia

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While potentiometric sensors experienced a golden age in the 1970s that drove innovation and implementation in the clinical laboratory as sensors of choice, it has been only fairly recently that a theoretical understanding coupled with modern materials approaches transformed the area of membrane electrodes from a playful, yet empirical field to one firmly rooted in scientific understanding. This paper summarizes key progress in the field during the past two decades, emphasizing that the key impulses at the time originated from the emerging field of optical ion sensors. This simplified and transformed the underlying theory of their potentiometric membrane electrode counterparts, where subsequently substantial progress was made, including the realization of ultra-trace detection limits. The better understanding of zero-current ion fluxes and transport processes in turn allowed the development of approaches utilizing dynamic electrochemistry principles, thereby drastically expanding the field of membrane electrodes and making available a range of new methodologies that would have been difficult to predict only a few years ago. These significant developments are now starting to come back and influence the field of optical sensors, where the control and triggering of dynamic processes, away from simpler equilibrium principles, are becoming a highly promising field of research.

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Imaging fiber microarray fluorescent ion sensors based on bulk optode microspheres

Cited by 43 publications

References 43 publications

Design of fluorescent materials for chemical sensing

Design of fluorescent materials for chemical sensing

Enzyme Substrates Protective Encapsulation within Polymeric Microspheres

Advancing Membrane Electrodes and Optical Ion Sensors

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