Imaging features of focal intrahepatic extramedullary haematopoiesis.

Wong, Yiu Chung; Chen, Frederick; Tai, KS; Yip, Linwah; Tsang, Kwt; Chan, F. L.; Ooi, G. C.

doi:10.1259/bjr.72.861.10645201

Cited by 49 publications

(39 citation statements)

References 15 publications

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“…1,2 In general, the reported characteristics of EMH on ultrasound, computed tomography, and MRI are quite variable, and even if clinical suspicion is high, these techniques are at best suggestive. 11,12 A number of radiotracers have been used to demonstrate EMH based on the various physiologic activities of the marrow. Perhaps the best known of these radiotracers are the colloids, such as Technetium-99m-colloid (99 mTc), which are taken up by macrophages.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Extramedullary Hematopoiesis

Bowling

Cauthen

Perry

et al. 2008

Journal of Thoracic Imaging

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Extramedullary hematopoiesis (EMH) is the formation and development of blood cells outside of the bone marrow. Of particular interest to chest physicians and radiologists is the occurrence of EMH in the lungs and pleura. There have been several reports of patients presenting with pulmonary EMH published in the literature and the majority are due to a secondary process, such as myeloproliferative disorders, hemolytic anemias, hereditary spherocytosis, and Gaucher disease. We present a case report of pulmonary EMH and a review of the literature concentrating on the etiology, clinical presentation, pathophysiology, diagnosis, and therapy for this uncommon disorder.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Extramedullary Hematopoiesis

Bowling

Cauthen

Perry

et al. 2008

Journal of Thoracic Imaging

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“…Radionuclide bone marrow scanning using Fe citrate are helpful in establishing the diagnosis by demonstrating activity in the mass [3,4,10] . However, caution should be exercised in the use of these modalities as the sole method of investigation because of the occasionally reported failure of these investigations to detect [10] and differentiate EMH from lymphoma [11] .…”

Section: Discussionmentioning

confidence: 99%

“…However, caution should be exercised in the use of these modalities as the sole method of investigation because of the occasionally reported failure of these investigations to detect [10] and differentiate EMH from lymphoma [11] . Therefore, the exclusion of malignancy obviates the need for tissue biopsy, preferably by a wide-bore (18 G) needle or Tru-Cut biopsy, as in our case.…”

Section: Discussionmentioning

confidence: 99%

Presacral Extramedullary Hematopoiesis: A Diagnostic Confusion concerning a Rare Presentation

Al-Aabassi

Murad

2005

Med Princ Pract

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Objective: To report a rare case of extramedullary hematopoiesis (EMH) with an asymptomatic intrapelvic mass in a patient with thalassemia major. Clinical Presentation: The patient presented with a pelvic mass discovered by ultrasonography before undertaking laparoscopic cholecystectomy for gallstones. Technetium-99m MDP bone scan failed to differentiate EMH from malignancy. A fine-needle aspiration smear was misdiagnosed when atypical megakaryocytes were interpreted as malignant cells. EMH was suggested by magnetic resonance imaging and confirmed by an ultrasound-guided Tru-Cut biopsy. Conclusion: This case report illustrates the need to consider EMH in the differential diagnosis of patients with chronic hematological disorders and mass lesions in extramedullary sites.

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“…Microscopically, there is diffuse infiltration of hematopoietic cells, altough there may be tumor-like masses of hematopoietic tissue with a variable degree of fibrosis [8,9]. Only 10-12 cases of focal intrahepatic EMH have been reported [10][11][12]. Few cases of nodular EMH diagnosed by FNA have been reported in the literature [13].…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic Extramedullary Hematopoietic Tumor Mimicking Metastatic Carcinoma from a Colonic Primary

et al. 2004

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Background: Extramedullary hematopoiesis (EMH) is associated with a number of diseases in which the normal function of the bone marrow is disturbed. While organs with hemopoietic capacity like the liver and spleen are most commonly involved, EMH has also occasionally been found in other organs like the adrenal gland, lymph nodes, breast, thymus, small bowel and central nervous system. However, presentation of a myeloproliferative disorder, such as EMH in these organs is a rare event. Case Report: We report clinical and fine-needle aspiration (FNA) findings in a patient who presented with intrahepatic EMH which mimicked metastatic carcinoma from a colonic primary. Results: Ultrasound-guided FNA of the intrahepatic mass revealed megakaryocytes and myelocytes thus establishing the diagnosis of EMH. Conclusions: EMH is an unusual condition that can mimic other solid masses of the liver. Because radiologic findings are not specific, EMH should be considered in the differential diagnosis, especially in patients with a myeloproliferative disorder. FNA and subsequent cytopathological interpretation of the aspirates enables avoidance of unnecessary potentially hazardous surgery.

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Imaging features of focal intrahepatic extramedullary haematopoiesis.

Cited by 49 publications

References 15 publications

Pulmonary Extramedullary Hematopoiesis

Pulmonary Extramedullary Hematopoiesis

Presacral Extramedullary Hematopoiesis: A Diagnostic Confusion concerning a Rare Presentation

Intrahepatic Extramedullary Hematopoietic Tumor Mimicking Metastatic Carcinoma from a Colonic Primary

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