Imaging features of bone metastases in patient with gastrointestinal stromal tumors

Jati, Anupma; Tatlı, Servet; Morgan, Jeffrey A.; Glickman, Jonathan N.; Demetri, George D.; Abbele, Annick Van Den; Silverman, Stuart G.

doi:10.4261/1305-3825.dir.5179-11.1

Cited by 24 publications

(26 citation statements)

References 14 publications

(20 reference statements)

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“…In a series of studies concerning metastatic GISTs, the incidence of bone metastasis was ~3% (15,16,20). However, the specific characteristics of patients with bone metastasis have not yet been identified.…”

Section: Discussionmentioning

confidence: 99%

“…PET-CT is useful for the early diagnosis of bone metastases that originate from GISTs. Upon PET-CT, metastatic bone lesions exhibit high 18 F-fluorodeoxyglucose avidity, similar to that of the liver and other metastatic sites (16). In the present study, PET-CT proved useful in achieving a diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…The most common metastatic sites are the liver and peritoneum, whereas GISTs are rarely found to metastasize intracranially or to the lymph nodes, lungs or subcutaneous tissue, as described in a limited number of previous case studies (5–7). Although a small number of studies have described bone metastases originating from GISTs (6,8–14), the true prevalence remains unknown (15,16). At present, the standard therapy for GIST is surgical complete resection, which is is possible in ~85% of patients.…”

Section: Introductionmentioning

confidence: 99%

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Bone metastasis of a gastrointestinal stromal tumor: A report of two cases

et al. 2015

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Abstract.Gastrointestinal stromal tumors (GISTs) are the most frequently diagnosed mesenchymal tumors of the GI tract. GISTs usually arise from the stomach, followed by the small intestine, rectum and other locations in the GI tract. The most common metastatic sites are the liver and peritoneum, whereas GISTs rarely metastasize to the bone. Although a small number of previous studies have described bone metastases originating from GISTs, the true prevalence is yet to be elucidated. The present study describes two cases of bone metastasis in patients with GISTs and reviews the relevant literature. Case one was of a 78-year-old male who presented with bone metastasis to the femoral neck five years after the resection of a GIST. The metastasis was completely resected and the patient remains alive nine years after the initial diagnosis of the GIST. Case 2 was of a 41-year-old male who presented with bone metastases to the ribs following resection of GISTs seven and 17 years earlier. The metastases were completely resected and the patient remains alive 17 years after the initial diagnosis. In total, only 10 cases of GISTs with metastases to the bone have been reported in the English literature. The possibility of bone metastases originating from a GIST should be considered during clinical follow-up, particularly in the presence of liver metastases. If feasible, bone metastases should be completely surgically excised.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bone metastasis of a gastrointestinal stromal tumor: A report of two cases

et al. 2015

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“…The frequency of bone metastasis from GIST has been reported to range from 3.2 to 6.0% [2, 3]. GIST-derived bone metastases are osteolytic lesions and occur most commonly in the spine and pelvis [2, 4, 5]. Swift treatment is needed for GIST-derived bone metastases in order to prevent pathological fractures, and many cases require emergent treatment [6].…”

Section: Introductionmentioning

confidence: 99%

“…Metastases from GIST commonly develop in the abdominal cavity and liver, but rarely arise in bones [1]. The frequency of bone metastasis from GIST has been reported to range from 3.2 to 6.0% [2, 3]. GIST-derived bone metastases are osteolytic lesions and occur most commonly in the spine and pelvis [2, 4, 5].…”

Section: Introductionmentioning

confidence: 99%

Cytological Findings of Gastrointestinal Stromal Tumor-Derived Bone Metastasis

et al. 2018

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Objective: Procedures for diagnosing bone tumors should be rapid and minimally invasive. Thus, cytological examinations are more useful for such purposes than histological examinations. In order to identify cytomorphological findings that could be used to diagnose bone metastasis from gastrointestinal stromal tumors (GIST), previous cases were reviewed. Study Design: Cytological samples of 7 lesions from 4 patients with GIST-derived bone metastasis, which were obtained from 2001 to 2017 at the JFCR Cancer Institute Hospital, were reviewed. Results: The metastasis of GIST to the bone was clinically suspected before the cytological and histological examinations in all cases since they all involved other metastatic lesion(s), and characteristic osteolytic lesions were detected on radiological images. Although various cell shapes were encountered, spindle cell proliferation was seen in all cytological samples. No pleomorphism was apparent. Characteristic nuclear findings were observed. All of the cases could be diagnosed as GIST-derived bone metastasis. Conclusion: GIST-derived bone metastasis can be diagnosed by examining cytological samples.

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Clinical and pathological characteristics of gastrointestinal stromal tumor (GIST) metastatic to bone

et al. 2017

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Our aim in this study was to describe the clinical, morphological, and molecular profile of gastrointestinal stromal tumor (GIST) metastatic to bone. We analyzed the morphological, phenotypic, and molecular characteristics of seven cases, and in addition reviewed 17 cases from literature. Sequence analysis of KIT and PDGFRA genes was possible for six cases. For the GIST cases with bone metastasis, the most common primaries were small intestine (29%), stomach (25%), and rectum (21%). Sites of bone metastases were vertebrae (11), pelvis (8), femur (8), ribs (6), humerus (5), skull (3), scapula (1), and mandible (1). The size ranged from 1.5 to 13 cm (median, 3.8 cm). Bone metastases without involvement of any other organ were seen in 17% of the cases and were solitary in 14 (58%). Adjacent soft tissue involvement was present in nearly half of the patients. Bone metastasis was either manifest at the time of diagnosis (28%) or occurred after a mean period of 4.7 years (3 months-20 years). Morphologically, neoplastic cells were spindle in 67%, epithelioid in 13%, and mixed epithelioid and spindle in 20%. CD117, DOG1, and CD34 were positive in 88, 86, and 85% of the cases, respectively. KIT Exon 11 mutations were the most frequent gene alteration (78%), followed by KIT Exon 13 mutations. Of 17 of the cases with available follow-up information, 7 (41%) patients developed bone metastasis under imatinib therapy. Five patients (29%) died of disease within a mean of 17 months. Bone metastases from GIST are usually found in patients with advanced disease and typically present as lytic masses with occasional soft tissue involvement. We could not identify any KIT or PDGFRA alterations predisposing to bone metastasis.

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Imaging features of bone metastases in patient with gastrointestinal stromal tumors

Cited by 24 publications

References 14 publications

Bone metastasis of a gastrointestinal stromal tumor: A report of two cases

Bone metastasis of a gastrointestinal stromal tumor: A report of two cases

Cytological Findings of Gastrointestinal Stromal Tumor-Derived Bone Metastasis

Clinical and pathological characteristics of gastrointestinal stromal tumor (GIST) metastatic to bone

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