Imaging features of automated breast volume scanner: Correlation with molecular subtypes of breast cancer

Zheng, Fei-Meng; Lü, Qing; Huang, Beijian; Xia, Han-Sheng; Yan, Lixia; Xi, Wang; Yuan, Wei; Wang, Wenping

doi:10.1016/j.ejrad.2016.11.032

Cited by 43 publications

(37 citation statements)

References 30 publications

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“…We found that TN invasive breast carcinoma was associated with sonographic features of regular shape, no angular/spiculated margin, posterior acoustic enhancement and no calcifications. This finding was in agreement with previous studies 9 , 10 , 12 , 15 , 20 – 24 . These four sonographic features were usually regarded as imaging characteristics of benign breast masses in BI-RADS lexicon.…”

Section: Discussionsupporting

confidence: 94%

Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature

Zhang

Shi

et al. 2018

Sci Rep

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In this study, we aimed to evaluate the clinical and pathological factors that associated with sonographic appearances of triple-negative (TN) invasive breast carcinoma. With the ethical approval, 560 patients who were pathologically confirmed as invasive breast carcinoma were reviewed for ultrasound, clinical, and pathological data. Logistic regression analysis was used to identify the typical sonographic features for TN invasive breast carcinomas. The effect of clinical and pathological factors on the sonographic features of TN invasive breast carcinoma was studied. There were 104 cases of TN invasive breast carcinoma. The independent sonographic features for the TN subgroup included regular shape (odds ratio, OR = 2.14, p = 0.007), no spiculated/angular margin (OR = 1.93, p = 0.035), posterior acoustic enhancement (OR = 2.14, p = 0.004), and no calcifications (OR = 2.10, p = 0.008). Higher pathological grade was significantly associated with regular tumor shape of TN breast cancer (p = 0.012). Higher Ki67 level was significantly associated with regular tumor shape (p = 0.023) and absence of angular/spiculated margin (p = 0.005). Higher human epidermal growth factor receptor 2 (HER2) score was significantly associated with the presence of calcifications (p = 0.033). We conclude that four sonographic features are associated with TN invasive breast carcinoma. Heterogeneity of sonographic features was associated with the pathological grade, Ki67 proliferation level and HER2 score of TN breast cancers.

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Section: Discussionsupporting

confidence: 94%

Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature

Zhang

Shi

et al. 2018

Sci Rep

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“…Breast cancer is a complex disease with varied therapeutic responses and clinical outcomes due to its heterogeneity . Current clinical practice for breast cancer management is generally based on histologic and molecular criteria .…”

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confidence: 99%

The Association Between Ultrasound Features and Biological Properties of Invasive Breast Carcinoma Is Modified by Age, Tumor Size, and the Preoperative Axilla Status

Tong

Sun

Zhou

et al. 2019

J of Ultrasound Medicine

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Objectives-To investigate the value of ultrasound (US) feature-based models in predicting the proliferation and invasiveness of invasive breast cancer (IBC) and to compare the performance of models based solely on US features with models that combined US features, patient age, tumor size, and axilla status from US.Methods-With ethical approval, 746 patients with a pathologic diagnosis of IBC were reviewed for preoperative clinical, US, and postoperative pathologic data. The proliferation and invasiveness properties of the IBC included the histologic grade and Ki-67 status and lymphovascular invasion (LVI) and axillary lymph node metastasis (ALNM), respectively. Logistic regression analyses were used to identify independent risk factors for tumor proliferation and invasiveness.Results-Posterior echo enhancement, calcification, a tumor size larger than 2 cm, and suspicion of ALNM from axillary US were independent risk factors for a high histologic grade and high Ki-67 expression of IBC (P < .05). A posterior echo shadow, patient age younger than 45 years, and suspicious findings on axillary US imaging were independent variables for predicting the presence of LVI and ALNM in IBC (P < .05). Calcification was the independent factor for predicting LVI (P = .013). The predictive performance of the combined models was improved compared with the US feature-based models, with a higher accuracy rate and negative predictive value. The area under curve of the combined models was also significantly higher than that of the single models (P < .05).Conclusions-Compared with the US feature-based models, the combined models yielded better predictive performance. This may provide a more robust model to predict the tumor biological properties of IBC before surgery.

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“…Zheng et al [47] in a study on 303 malignant breast tumours shows a strong correlation between the "retraction phenomenon" and the molecular subtypes.…”

Section: Other Applicationsmentioning

confidence: 96%

Automatic breast ultrasound: state of the art and future perspectives

Nicosia¹,

Ferrari²,

Bozzini³

et al. 2020

ecancer

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The three-dimensional automated breast ultrasound system (3D ABUS) is a new device which represents a huge innovation in the breast ultrasound field, with several application scenarios of great interest. ABUS's aim is to solve some of the main defects of traditional ultrasound, such as lack of standardization, high level of skill non-reproducibility, small field of view and high commitment of physician time. ABUS has proven to be an excellent non-ionising alternative to other supplemental screening options for women with dense breast tissue; also, it has appeared to be very promising in daily clinical practice. The purpose of this paper is to present a summary of current applications of ABUS, focusing on clinical applications and future perspectives as ABUS is particularly promising for studies involving artificial intelligence, radiomics and evaluation of breast molecular subtypes.

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Imaging features of automated breast volume scanner: Correlation with molecular subtypes of breast cancer

Cited by 43 publications

References 30 publications

Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature

Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature

The Association Between Ultrasound Features and Biological Properties of Invasive Breast Carcinoma Is Modified by Age, Tumor Size, and the Preoperative Axilla Status

Automatic breast ultrasound: state of the art and future perspectives

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