Imaging features and functional outcome in a case of idiopathic acute exudative polymorphous vitelliform maculopathy

Sommer, Michael; Singer, Christoph; Djavid, Daniel; Seidel, Gerald

doi:10.1016/j.ajoc.2020.100870

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…Again, we review the results of the ophthalmologic examination, idiopathic Acute Exudative Polymorphous Vitelliform Maculopathy (AEPVM) was considered. 11 And then we looked in the literature further and found that if we diagnosed this disease, we should rule out carefully other underlying masquerading diseases and specifically paraneoplastic syndromes. 12 In addition, the patient had been diagnosed with thymoma 20 years prior; 15 years prior, she had been diagnosed with MG; 3 years prior, she had been diagnosed with rheumatic immune system paraneoplastic symptoms-polymyositis.…”

Section: Discussionmentioning

confidence: 99%

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis

Tong

et al. 2021

European Journal of Ophthalmology

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Importance: This is the first reported case of acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM) in a patient with thymoma, accompanied by myasthenia gravis (MG) and polymyositis. Objective: To examine the pathogenesis of ocular disease in a patient with yolk-like fundus lesions and thymoma, MG, and polymyositis throughout the body based on clinical manifestations, diagnosis, differential diagnosis, and genetic testing to determine the appropriate treatment course. Design, setting, and participants: We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0 × 1.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patient’s medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20 years prior), followed by a diagnosis of MG with suspect thymic association (15 years prior). Three years prior, the patient had been diagnosed with polymyositis related to paraneoplastic syndrome; 1 year prior, she had been examined for pleural thickening due to suspected metastatic tumor. Results: On her most recent follow-up visit at 3 months after initial diagnosis, the patient was stable with no clinically significant progression in ocular or systemic conditions.

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Section: Discussionmentioning

confidence: 99%

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis

Tong

et al. 2021

European Journal of Ophthalmology

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“…Multimodal retinal imaging is key for the differential diagnosis and to adequately evaluate lesion progression over time. Colour fundus photography (CFP), SD-OCT and FAF usually provide enough information to establish a clinical diagnosis, but in cases of suspected macular neovascularisation, or inflammation dye-based angiography imaging is warranted 14. CFP was performed to document the findings in the posterior pole, as can be seen in figure 1.…”

Section: Investigationsmentioning

confidence: 99%

“…On the other hand, similarities are also evident between AEPVM and vitelliform macular dystrophies such as multifocal BVMD or ARB, although no genetic association has ever been found in patients with AEPVM. Interestingly, there are only ~20 idiopathic cases reported in the literature to date 1 13 14…”

Section: Introductionmentioning

confidence: 99%

Idiopathic acute exudative polymorphous vitelliform maculopathy: the importance of multimodal imaging, systemic workup and genetic testing

et al. 2023

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The authors describe a case of acute exudative polymorphous vitelliform maculopathy (AEPVM) in an otherwise healthy man in his 60s complaining of subacute bilateral blurred vision. At examination, best-corrected visual acuity was 20/32 in the right eye and 20/40 in the left eye. Bilateral central large serous detachments with inferior meniscus-like deposition of a vitelliform-like material were observed at funduscopy and confirmed by spectral-domain optical coherence tomography. Small vitelliform-like lesions along the temporal superior vascular arcades were also seen. The lesions with vitelliform appearance appeared hyperautofluorescent on fundus autofluorescence. A complete systemic workup and genetic testing were performed and the diagnosis of idiopathic AEPVM was established. Six months later, a complete resolution of the lesions was observed.

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Imaging features and functional outcome in a case of idiopathic acute exudative polymorphous vitelliform maculopathy

Cited by 2 publications

References 2 publications

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis

Idiopathic acute exudative polymorphous vitelliform maculopathy: the importance of multimodal imaging, systemic workup and genetic testing

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