Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism

Abstract

In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with nonmotor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson’s disease dementia, and Alzheimer’s disease are discussed.

Neuroimaging Advances in Neurologic and Neurodegenerative Diseases

“…This review captures the variability and heterogeneity in FTLD and their links to imaging patterns. Finally, Brooks (2020) provides a comprehensive review of neuroimaging in PD and related disorders (such as LBD), focusing on MRI, SPECT (i.e., DATScan), and PET findings (primarily dopamine-focused and other neurotransmitter-focused tracers) [4].…”