Imaging evidence of the relationship between atherosclerosis and chronic obstructive pulmonary disease

Pike, Damien; Lindenmaier, Tamas J; Sin, Don D.; Párraga, Grace

doi:10.2217/iim.13.70

Cited by 5 publications

(3 citation statements)

References 126 publications

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“…10 Furthermore, subclinical 11 and clinical atherosclerosis have been robustly associated with and suggested as contributing factors for the development of isolated PE in large retrospective studies, [12][13][14] although the cross-sectional nature of these investigations has precluded definitive conclusions as to the direction of the risk relationship. A common mechanism involved in the described clinical conditions that also predisposes to in situ pulmonary thrombosis is a persistent local inflammatory process, 11,[15][16][17] which also entails chronically elevated levels of proinflammatory cytokines in the systemic circulation. 17,18 Because of the evidence suggesting that isolated PE constitutes an in situ phenomenon distinct from DVTassociated PE, and on the suspicion that isolated PE may share causative mechanisms with arterial cardiovascular disease, we hypothesized that the presence of isolated PE may signal an elevated risk of arterial thrombotic disease.…”

mentioning

confidence: 99%

Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease

Cate

Eggebrecht

Schulz

et al. 2020

Chest

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mentioning

confidence: 99%

Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease

Cate

Eggebrecht

Schulz

et al. 2020

Chest

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“…The increased risk is also linked with the unique physiological crosstalk between the lungs and heart, which is unlike that in other organs. Indeed, research indicates that lung inflammation, as seen in conditions like SARS-CoV-2 infection, significantly impacts the heart due to the interconnectedness of the cardiopulmonary system ( 100 ). A substantial portion of the COPD disease burden relates to the management of cardiovascular comorbidities and infectious AE-COPD.…”

Section: Inflammatory Mechanisms In Ami and Copdmentioning

confidence: 99%

Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Marriott,

Singanayagam,

El-Awaisi

2024

Front. Cardiovasc. Med.

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Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions. Although extensive research has been conducted on individual inflammatory pathways in AMI and COPD, the understanding of thrombo-inflammatory crosstalk in comorbid settings remains limited. The effectiveness of various inflammatory components in reducing AMI infarct size or slowing COPD progression has shown promise, yet their efficacy in the context of comorbidity with COPD and AMI is not established. This review focuses on the critical importance of both local and systemic inflammation, highlighting it as a key pathophysiological connection between AMI and COPD/AE-COPD.

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“…Although COPD is a lung condition, it is associated with significant extrapulmonary pathology, in particular cardiovascular disease [ 2 ]. The mechanisms driving this are complex, being influenced by a number of shared pathophysiological mechanisms including smoking, systemic cellular inflammation, oxidative stress and sedentarism [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial

Alasmari,

Alsulayyim,

Alghamdi

et al. 2023

Eur Respir J

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BackgroundShort term studies suggest that dietary nitrate supplementation may improve cardiovascular risk profile, lowering blood pressure (BP) and enhancing endothelial function. It is not clear if these beneficial effects are sustained and whether they apply in people with COPD, who have a worse cardiovascular profile than those without COPD. Nitrate-rich beetroot juice BRJ (NR-BRJ) is a convenient dietary source of nitrate.MethodsThe ON-BC trial was a randomized, double-blind, placebo-controlled parallel group study in stable COPD patients with home systolic BP (SBP) measurement ≥130 mmHg. Participants were randomly allocated (1:1) using computer-generated, block randomization to either 70 mL of NR-BRJ (400 mg NO3−) (n=40) or an otherwise identical nitrate-depleted placebo juice Pl-BRJ (0 mg NO3−) (n=41), once daily for 12 weeks. The primary endpoint was between group change in home SBP measurement. Secondary outcomes included change in 6-minute walking distance (6MWD) and measures of endothelial function (reactive hyperaemia index (RHI) and augmentation index (AIx75)) using an EndoPAT device. Plasma nitrate and platelet function were also measured.ResultsCompared to placebo, active treatment lowered SBP (Hodges-Lemman treatment effect MD[95% CI]; −4.5[-3.0 to −5.9] improved 6MWD (+30.0 m [15.7 to 44.2], p<0.001), RHI +0.34 (0.03 to 0.63) p=0.03, and AIx75 −7.61% [-14.3 to −0.95], p=0.026.ConclusionsIn people with COPD, prolonged dietary nitrate supplementation in the form of beetroot juice produces a sustained reduction in BP, associated with an improvement in endothelial function and exercise capacity.

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Imaging evidence of the relationship between atherosclerosis and chronic obstructive pulmonary disease

Cited by 5 publications

References 126 publications

Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease

Isolated Pulmonary Embolism Is Associated With a High Risk of Arterial Thrombotic Disease

Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial

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