Imaging evaluation of lymphadenopathy and patterns of lymph node spread in head and neck cancer

Forghani, Reza; Yu, Eugene; Levental, Mark; Som, Peter M.; Curtin, Hugh D.

doi:10.1586/14737140.2015.978862

Cited by 43 publications

(26 citation statements)

References 66 publications

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“…The qualitative diagnosis of malignant lesions in the cervical lymph node directly affects the selection of treatment options and the patient prognosis 16 17 . Previous imaging diagnoses of lymph node lesions have mainly depended on changes in lesion morphology, such as the size, shape, and necrotic area 18 . Although malignant lesions in different cervical lymph nodes manifest certain imaging characteristics, and typical cases are not difficult to diagnose, some atypical cases cannot be diagnosed accurately because conventional imaging techniques cannot provide specificity and sensitivity simultaneously.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of malignant cervical lymphadenopathy by dual-energy CT: a preliminary analysis

Yang

Luo

Lin

et al. 2016

Sci Rep

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The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC), squamous cell carcinoma (SCC) and lymphoma. We retrospectively analysed 92 patients with pathologically confirmed cervical lymphadenopathy due to TC, SC, SCC and lymphoma. All patients received a DECT scan before therapy. Using GSI (gemstone spectral imaging) Volume Viewer software, we analysed the enhanced monochromatic data, and the quantitative parameters we acquired included the iodine concentration (IC), water concentration (WC) and the slope of the spectral HU curve (λHU). One-way ANOVA showed significant differences in the IC and λHU among different groups (P < 0.05). Post-hoc pairwise comparisons demonstrated the IC and λHU of TC group were significantly higher than those of SC, SCC and lymphoma groups (P < 0.05). In addition, the IC and λHU of SC group were significantly higher than those of the SCC and lymphoma groups (P < 0.05). Other comparisons of IC and λHU values showed no significant differences (P > 0.05). The quantitative parameters derived from DECT were useful supplements to conventional computed tomography images and were helpful for distinguishing different malignant cervical lymphadenopathies.

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Section: Discussionmentioning

confidence: 99%

Differentiation of malignant cervical lymphadenopathy by dual-energy CT: a preliminary analysis

Yang

Luo

Lin

et al. 2016

Sci Rep

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“…Only grossly pathologic nodes were evaluated on the basis of either 1) biopsy or neck dissection, when such results were available, or 2) an abnormal-appearing node in the primary or secondary drainage area of the primary tumor by at least 2 criteria among the following: abnormal short-axis diameter, internal necrosis/heterogeneity, rounded contour, or irregular contour. 22 For tumors and lymph nodes, the ROIs were placed in the homogeneous-appearing enhancing part of the lesion, avoiding areas of cystic change/ necrosis or visible artifacts. For muscles, the ROIs were placed in areas without visible artifacts.…”

Section: Postprocessing and Image Analysismentioning

confidence: 99%

Optimal Virtual Monochromatic Images for Evaluation of Normal Tissues and Head and Neck Cancer Using Dual-Energy CT

Lam

Gupta

Levental

et al. 2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Dual-energy CT is not used routinely for evaluation of the head and neck, and there is no consensus on the optimal virtual monochromatic image energies for evaluating normal tissues or head and neck cancer. We performed a quantitative evaluation to determine the optimal virtual monochromatic images for visualization of normal tissues, head and neck squamous cell carcinoma, and lymphadenopathy.

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“…This includes ultrasound exams of the head and neck for evaluation of cervical lymphadenopathy, salivary gland disorders and head and neck cancer [21–23]. Additionally, there is a general lack of guidance in the use of technical terms and report structure in this field, leading to great variability in report content [1, 24]. Therefore, establishing a standard for ultrasound reports using structured reporting may be greatly beneficial for physicians acquiring ultrasound skills as well as for the referring clinician [25, 26].…”

Section: Introductionmentioning

confidence: 99%

Structured reporting of head and neck ultrasound examinations

et al. 2019

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Background Reports of head and neck ultrasound examinations are frequently written by hand as free texts. Naturally, quality and structure of free text reports is variable, depending on the examiner’s individual level of experience. Aim of the present study was to compare the quality of free text reports (FTR) and structured reports (SR) of head and neck ultrasound examinations. Methods Both standard FTRs and SRs of head and neck ultrasound examinations of 43 patients were acquired by nine independent examiners with comparable levels of experience. A template for structured reporting of head and neck ultrasound examinations was created using a web-based approach. FTRs and SRs were evaluated with regard to overall quality, completeness, required time to completion, and readability by four independent raters with different specializations (Paired Wilcoxon test, 95% CI) and inter-rater reliability was assessed (Fleiss’ kappa). A questionnaire was used to compare FTRs vs. SRs with respect to user satisfaction (Mann-Whitney U test, 95% CI). Results By comparison, completeness scores of SRs were significantly higher than FTRs’ completeness scores (94.4% vs. 45.6%, p < 0.001), and pathologies were described in more detail (91.1% vs. 54.5%, p < 0.001). Readability was significantly higher in all SRs when compared to FTRs (100% vs. 47.1%, p < 0.001). The mean time to complete a report, however, was significantly higher in SRs (176.5 vs. 107.3 s, p < 0.001). SRs achieved significantly higher user satisfaction ratings (VAS 8.87 vs. 1.41, p < 0.001) and a very high inter-rater reliability (Fleiss’ kappa 0.92). Conclusions As compared to FTRs, SRs of head and neck ultrasound examinations are more comprehensive and easier to understand. On the balance, the additional time needed for completing a SR is negligible. Also, SRs yield high inter-rater reliability and may be used for high-quality scientific data analyses.

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Imaging evaluation of lymphadenopathy and patterns of lymph node spread in head and neck cancer

Cited by 43 publications

References 66 publications

Differentiation of malignant cervical lymphadenopathy by dual-energy CT: a preliminary analysis

Differentiation of malignant cervical lymphadenopathy by dual-energy CT: a preliminary analysis

Optimal Virtual Monochromatic Images for Evaluation of Normal Tissues and Head and Neck Cancer Using Dual-Energy CT

Structured reporting of head and neck ultrasound examinations

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