Imaging Evaluation of Cutaneous Lymphoma Using Functional and Structural Imaging

Fardin, Sara; Gholami, Somayeh; Werner, Tom; Rook, Alain H.; Alavi, Abass

doi:10.1016/b978-0-12-802838-4.00035-2

Cited by 2 publications

(4 citation statements)

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“…Primary cutaneous lymphomas are frequently multifocal and physical examination largely underestimates the disease burden. 5,6 Although, HRUS can show the sonographic features and the extent of the infiltration of the lesions in the cutaneous layers, it does not show the progression of the disease beyond the primary superficial lesion. Another limitation of HRUS is that, it only suggests the diagnosis and guides the biopsy but does not confirm it.…”

Section: Discussionmentioning

confidence: 99%

“…PET alone has poor anatomical resolution, but FDG PET and CT, together, has proved superior to CT in the staging, restaging and extranodal detection of lymphomas. 5,20,21 PET-CT is the modality of choice in detecting extracutaneous involvement, monitoring the post-therapeutic disease activity and is routinely recommended for the staging of patients with FDG-avid, potentially curable lymphomas. 5,6 PET-CT imaging has revealed increased up take of FDG in the cutaneous lesions in 92.3% of the cases in our study (Figures 6-8).…”

Section: Discussionmentioning

confidence: 99%

“…5,20,21 PET-CT is the modality of choice in detecting extracutaneous involvement, monitoring the post-therapeutic disease activity and is routinely recommended for the staging of patients with FDG-avid, potentially curable lymphomas. 5,6 PET-CT imaging has revealed increased up take of FDG in the cutaneous lesions in 92.3% of the cases in our study (Figures 6-8). We have, in our series, one case of PCBCL revealing extensive skeletal metastases on PET-CT, and review of literature has not revealed any other case with skeletal metastases (Figure 9).…”

Section: Discussionmentioning

confidence: 99%

“…Primary cutaneous lymphoma accounts for 19% of extranodal lymphomas with an estimated annual incidence of 1:100,000 and the approximate subtype incidence is about 65% for PCTCLs, 25% for PCBCLs, the rest being the NK cell neoplasms. 1,[3][4][5] The clinical manifestations of primary cutaneous lymphomas are completely dissimilar to those of secondary cutaneous lymphomas, i.e. nodal or systemic malignant lymphomas which secondarily involve the skin.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The clinical value of imaging in primary cutaneous lymphomas: Role of high resolution ultrasound and PET-CT

Mandava

Koppula

Wortsman

et al. 2019

The British Journal of Radiology

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Background: Primary cutaneous lymphoma is a rare extranodal non-Hodgkin’s lymphoma confined to the skin. The data on the imaging findings of primary cutaneous lymphomas are largely lacking and the current diagnosis is based on clinical and histopathological examination. With the advances in dermatological ultrasound and molecular imaging, newer perspectives in the evaluation of cutaneous lymphomas are available. Objective: To review and describe the imaging findings in patient’s with the diagnosis of primary cutaneous lymphoma. Methods: A multicentric, retrospective observational study was undertaken in four countries to review the high resolution ultrasonography (HRUS) and fluorine 18-fludeoxyglucose positron emission tomography-computed tomography (PET-CT) imaging findings. Results: We had 41 patients, Female:Male 1:4.1; mean age, 57 years; range, 13–94 years. High resolution ultrasonography of the primary cutaneous lesions revealed thickening of the dermis in all the cases and the lesions were hypoechoic without any calcifications or central necrosis. The sonographic appearances of the lesions were categorised into focal infiltrative, nodular, pseudonodular, and diffusely infiltrative patterns. Nodular and pseudonodular lesions were predominant in B cell lymphomas, while diffusely infiltrative lesions were more common in T-cell lymphomas. On colour Doppler imaging, the lesions were hypervascular. Whole body 18F-fludeoxyglucose PET–CT imaging of the patients revealed increased uptake of the metabolite in the lesions. Conclusion: Sonographic patterns based on high resolution ultrasonography provide early clues to the non-invasive diagnosis of primary cutaneous lymphomas and PET-CT is the recommended modality of imaging for staging and follow-up. Advances in knowledge: High resolution ultrasound with colour Doppler and PET-CT imaging are complimentary to the clinical diagnosis of primary cutaneous lymphomas.

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Section: Discussionmentioning

confidence: 99%