Imaging Efficacy of a Hepatocyte-Selective Polyiodinated Triglyceride for Contrast-Enhanced Computed Tomography

Abstract

In the animal model tested, DHOG-LE imaging efficacy was directly related to iodine dose and was independent of formulation composition. Thus, administration of DHOG-LE in highly concentrated lipid preparations minimized administered dose volume and resulted in appreciable liver enhancement, even at the lowest dose of 50 mg I/kg.

MicroCT Liver Contrast Agent Enhancement Over Time, Dose, and Mouse Strain

“…Some of the benefits of organ-selective contrast agents include reduced systemic toxicity, lower overall dose, and the potential to obtain functional and anatomical information [5]. Another benefit of this contrast agent is that it has a long residual activity, even allowing for only one injection per week if needed, which is much longer than water-soluble contrast agents.…”

In‐vivo high‐resolution X‐ray microtomography for liver and spleen tumor assessment in mice

“…A 20% oil-in-water emulsion of glyceryl-2-oley-1,3-bis-[7-(3-amino-2,4,6-triiodophenyl)-heptanoate] (DHOG), corresponding to a polyiodinated triglyceride (ITG) analog incorporated in a neutral lipid core of chylomicron remnant-like lipid emulsion with particles of less than 200 nm in diameter, was shown to enable high-quality long-lasting visualization in micro-CT imaging studies, especially of the liver (8,(10)(11)(12)(13). Once sequestered by the liver, the triglyceride core is metabolized and excreted through the biliary system and taken up by the liver through a high-capacity receptor-mediated apolipoprotein-E process.…”

Structural imaging of the pancreas in rat using micro-CT: application to a non-invasive longitudinal evaluation of pancreatic ductal carcinoma monitoring

“…According to the manufacturer recommends, the ITG contrast enhancers for CT, trade-named Fenestra liver contrast (LC) and vascular contrast (VC) both from Advanced Research Technologies (Inc., Montreal, Canada), [9][10][11] should be injected together intravenously (vol/vol) at the dose of 1 ml/100 g of body weight for each of them, with a iodine concentration of 50 mg/ml. Such a fluid volume highly exceeds the maximal intravenous amount allowed by the European current best practice guideline, which is 0.5 ml/100 g body weight at the maximum corresponding to 10% of the rat volemia.…”

“…tool remains still relatively rare in small animal studies [5][6][7][8][9][10][11][12][13][14][15]. Furthermore until now, very few data concerning its use for pancreatic imaging in animal models have been reported in the literature [16].…”