Imaging diffusion in a microfluidic device by third harmonic microscopy

Petzold, Uwe; Büchel, A.; Hardt, Steffen; Halfmann, Thomas

doi:10.1007/s00348-012-1321-5

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…The material properties were those of water (density ~1000 kg/m 3 and dynamic viscosity ~0.001 Pa·s). A diffusion coefficient was used for the fluids 25 , 26 . Fluid flow rate was 400 μL/min.…”

Section: Resultsmentioning

confidence: 99%

Ultrafast Synthesis of Multifunctional Submicrometer Hollow Silica Spheres in Microfluidic Spiral Channels

Nie

Hao

Zhang

2017

Sci Rep

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We demonstrate a facile and ultrafast approach for the synthesis of multifunctional submicrometer hollow silica spheres (smHSSs) using microfluidic spiral channels with enhanced mixing performance, introduced by the transverse Dean flows cross the channel as a result of centrifugal effects. Formation of smHSSs is initiated by the hydrolysis of tetraethyl orthosilicate (TEOS) at the interface of two laminar reactant flows. Complete mixing of the flows further facilitates the subsequent condensation of hydrolyzed TEOS, which builds up the shell layer of smHSSs. The average size of the as-synthesized smHSSs is 804.7 nm, and the thickness of the shell layer is ~20 nm. Multifunctional smHSSs integrated with proteins, fluorescent dyes, quantum dots, and magnetic nanoparticles can be further produced via this general platform. Their applications in cell imaging, organic dye adsorption, and drug delivery are examined.

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Section: Resultsmentioning

confidence: 99%

Ultrafast Synthesis of Multifunctional Submicrometer Hollow Silica Spheres in Microfluidic Spiral Channels

Nie

Hao

Zhang

2017

Sci Rep

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“…One of its typical applications is to separate the desired chemical from a multicomponent solution by cascading multiple identical diffusers. Diffusion measurement in a microfluid typically relies on fluorescence, Raman or opticalnonlinearity-based spectroscopy [40][41][42][43] . Scanning acoustic microscopy can be used to measure the acoustic impedance in nondestructive testing and biomedical applications for the detection of lesions, but the mechanical scanning of ultrasonic transducers is not suitable for microfluidics 44 .…”

Section: Conceptmentioning

confidence: 99%

High spatiotemporal resolution optoacoustic sensing with photothermally induced acoustic vibrations in optical fibres

et al. 2021

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Optoacoustic vibrations in optical fibres have enabled spatially resolved sensing, but the weak electrostrictive force hinders their application. Here, we introduce photothermally induced acoustic vibrations (PTAVs) to realize high-performance fibre-based optoacoustic sensing. Strong acoustic vibrations with a wide range of axial wavenumbers kz are photothermally actuated by using a focused pulsed laser. The local transverse resonant frequency and loss coefficient can be optically measured by an intra-core acoustic sensor via spectral analysis. Spatially resolved sensing is further achieved by mechanically scanning the laser spot. The experimental results show that the PTAVs can be used to resolve the acoustic impedance of the surrounding fluid at a spatial resolution of approximately 10 μm and a frame rate of 50 Hz. As a result, PTAV-based optoacoustic sensing can provide label-free visualization of the diffusion dynamics in microfluidics at a higher spatiotemporal resolution.

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“…Alcohol-water mixtures have been of great interest because they are widely used in biochemistry, medicine, and food science, and because their hydration structure and thermodynamic properties vary anomalistically [35][36][37][38][39][40][41][42]. Fluorescence-based techniques [8,17], third harmonic microscopy [43], coherent anti-Stokes Raman scattering microscopy [44], surface plasmon resonance reflectance imaging [45], and terahertz time-domain spectroscopy [46] have been used to measure/image alcohol concentrations in water. However, none of these techniques has been applied to simultaneous imaging of temperature and concentration, as mentioned above.…”

Section: Measurement Science and Technologymentioning

confidence: 99%

Simultaneous imaging of temperature and concentration of ethanol–water mixtures in microchannel using near-infrared dual-wavelength absorption technique

Kakuta

Yamashita

Kawashima

et al. 2016

Meas. Sci. Technol.

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This paper presents a simultaneous imaging method of temperature and ethanol concentration of ethanol-water mixtures in microfluidic channels. The principle is based on the facts that the absorbance at a wavelength of 1905 nm is dependent on the temperature of water and that the absorbance at 1935 nm is independent of the temperature but strongly dependent on the molar concentration of water, which is reciprocal to the molar concentration of ethanol in the mixture. The absorbance images at the two wavelengths were acquired alternately, each at 50 frames per second, by an alternate irradiation system and near-infrared (NIR) camera, and then converted to the temperature and concentration images by a linear regression model. The imaging method was applied to a dilute ethanol-water mixture with an ethanol concentration of 0.43 M and water flowing side by side in a temperature-controlled Y-channel. The concentration images clearly showed differences between the mixture and water streams, and that the transverse concentration gradient between the two streams decreased downstream by mutual diffusion. It was also confirmed that the mutual diffusion coefficient increased as the temperature increased. The temperature images showed that uniform distributions were immediately formed due to heat transfer between the fluid and channel materials.

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Imaging diffusion in a microfluidic device by third harmonic microscopy

Cited by 7 publications

References 30 publications

Ultrafast Synthesis of Multifunctional Submicrometer Hollow Silica Spheres in Microfluidic Spiral Channels

Ultrafast Synthesis of Multifunctional Submicrometer Hollow Silica Spheres in Microfluidic Spiral Channels

High spatiotemporal resolution optoacoustic sensing with photothermally induced acoustic vibrations in optical fibres

Simultaneous imaging of temperature and concentration of ethanol–water mixtures in microchannel using near-infrared dual-wavelength absorption technique

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