Imaging Diagnosis-Canine Meningioangiomatosis

Gonçalves, Rita; Johnston, Pamela; Wessmann, Annette; Penderis, Jacques

doi:10.1111/j.1740-8261.2009.01640.x

Cited by 5 publications

(10 citation statements)

References 12 publications

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“…105 Human MA has often been reported in association with other lesions of the CNS, most often with an overlying meningioma, 76 as was reported in one dog. 32 This disorder is only described in 12 dogs, 9,32,35,57,79,82,93,101 one horse, 26 one cow, 43 and one mouse, 3 while 3 additional canine cases reside in our archive (unpublished data). Previous potentially misidentified cases may include reports of murine meningeal tumors diagnosed as "meningeal sarcoma" 66 and "malignant meningioma," 68 which were so classified based on the pattern of infiltration into brain along the adventitia of small blood vessels.…”

Section: Meningioangiomatosismentioning

confidence: 90%

“…One small case series reported the age range of affected dogs as 4 to 14 months, 9 although in a solitary case report, the dog was 9 years old at the time of diagnosis. 79 In addition to the brainstem, canine MA was also reported in the cervical 9 and thoracolumbar spinal cord, 35 while spinal lesions of MA have not been reported in the human literature. The clinical presentation of MA in animals again depends on the involved area, but common clinical signs include those characteristic of local brain invasion and compression.…”

Section: Meningioangiomatosismentioning

confidence: 99%

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A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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In disease, blood vessel proliferation has many salient roles including in inflammation, when granulation tissue fills superficial defects, or in the recanalization of an occluded blood vessel. Sometimes angiogenesis goes awry—granulation can be exuberant, and plexiform proliferation of vascular components can contribute to pulmonary hypertension. This review focuses on the diverse manifestations of pathologic vascular overgrowth that occur in the brain, spinal cord, and meninges of animals from birth until old age. Entities discussed include systemic reactive angioendotheliomatosis in which glomeruloid vascular proliferations are encountered in various organs including the central nervous system (CNS). The triad of CNS vascular malformations, hamartomas, and benign vascular proliferations are an especially fraught category in which terminology overlap and the microscopic similarity of various disorders makes diagnostic classification incredibly challenging. Pathologists commonly take refuge in “CNS vascular hamartoma” despite the lack of any unique histopathologic features and we recommend that this diagnostic category be abandoned. Malformative lesions that are often confusing and have similar features; the conditions include arteriovenous malformation, cavernous angioma, venous angioma, and capillary telangiectases. Meningioangiomatosis, a benign meningovascular proliferation with dual components, is a unique entity seen most commonly in young dogs. Last, accepted neoplastic conditions range from lower-grade locally acquired growths like hemangioblastoma (a tumor of mysterious interstitial stromal cells encountered in the setting of abundant capillary vasculature proliferation), the rare hemangioendothelioma, and the highly malignant and invariably multifocal metastatic hemangiosarcoma. Additionally, this review draws on the comparative medical literature for further insights into this problematic topic in pathology.

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Section: Meningioangiomatosismentioning

confidence: 90%

Section: Meningioangiomatosismentioning

confidence: 99%

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

et al. 2020

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“…In veterinary medicine, MA was first described in a dog in 1988, 18 with 12 canine cases reported since then. 2,5,6,9,12,13,17,18 Based on limited evidence from these cases, MA appears to affect younger dogs <1-y-old; no apparent breed or sex predisposition has been observed. Clinical signs vary according to the anatomic location of the lesions, with affected dogs displaying seizures and variable neurologic deficits in postural reactions and gait.…”

mentioning

confidence: 97%

“…10,19 The characteristic lesion of MA consists of a proliferation of meningothelial and spindle cells (presumably meningeal fibroblasts) that efface the subarachnoid spaces and typically extend along the perivascular spaces into the outer encephalic or spinal cord neuroparenchyma. 2,6,15…”

mentioning

confidence: 99%

“…Clinical signs vary according to the anatomic location of the lesions, with affected dogs displaying seizures and variable neurologic deficits in postural reactions and gait. 2,5,6,9,12,13,17,18 A presumptive clinical diagnosis is challenging given that too few cases of MA have been described to develop characteristic imaging findings. MRI typically reveals an extraparenchymal lesion that is primarily T2-hyperintense with focal areas of hypointensity, and T1-hypointense with variable degrees of contrast enhancement.…”

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confidence: 99%

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Encephalic meningioangiomatosis in a cat

et al. 2022

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Meningioangiomatosis (MA) is a rare proliferative meningovascular entity that has been described mainly in humans and dogs. Here we describe MA in a 13-y-old spayed female domestic shorthaired cat that died 5 d after acute change in behavior, open-mouth breathing, seizures, hyperthermia, and inability to walk. On MRI, the lesion appeared predominantly as extraparenchymal hemorrhage. Autopsy changes consisted of a dark-red, hemorrhagic plaque that expanded the leptomeninges and outer neuroparenchyma of the right piriform and temporal telencephalic lobes, chalky white nodules in the peripancreatic fat, and yellow fluid in the abdomen. Histologically, the lesion in the brain consisted of leptomeningeal thickening by spindle cells that effaced the subarachnoid spaces and extended perivascularly into the underlying cerebral cortex. Spindle cells were arranged as streams or whorls around blood vessels, and had slender eosinophilic cytoplasm and elongated nuclei with coarsely stippled chromatin and 1 or 2 distinct nucleoli. There was extensive hemorrhage, clusters of hemosiderin-laden macrophages, and mineralization throughout. Spindle cells had positive immunolabeling for vimentin. A striking MRI and gross feature in our case was the extensive hemorrhage associated with the MA lesion. Additional findings included suppurative pancreatitis with peritonitis and supraspinatus myonecrosis.

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Nervous System

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2022

Veterinary Surgical Oncology

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Imaging Diagnosis-Canine Meningioangiomatosis

Cited by 5 publications

References 12 publications

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

A Review of Proliferative Vascular Disorders of the Central Nervous System of Animals

Encephalic meningioangiomatosis in a cat

Nervous System

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