Imaging Diagnosis—acquired Goitrous Hypothyroidism Following Treatment With Trimethoprim Sulfamethoxazole

Taeymans, Olivier; O'marra, Shana K.

doi:10.1111/j.1740-8261.2009.01563.x

Cited by 4 publications

(9 citation statements)

References 11 publications

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“…A palpable goiter may develop in dogs treated chronically with potentiated sulfonamides (Seelig et al, 2008;Taeymans and O'Marra, 2009). A palpable goiter may develop in dogs treated chronically with potentiated sulfonamides (Seelig et al, 2008;Taeymans and O'Marra, 2009).…”

Section: Miscellaneous Causesmentioning

confidence: 99%

Hypothyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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Section: Miscellaneous Causesmentioning

confidence: 99%

Hypothyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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“…In addition, human patients treated with some medications (eg, metoclopramide, amiodarone) can develop slightly increased serum TSH concentrations . Similarly, transiently high serum TSH concentrations can develop in dogs with nonthyroidal disease (with hypoadrenocorticism being the best characterized example), as well as during treatment with certain drugs . Therefore, it is clear that more studies evaluating serum TSH concentrations in a larger population of cats are needed—especially in cats with nonthyroidal illness during the recovery phase of illness, as well as after treatment with medications known to increase serum TSH in other species.…”

Section: Discussionmentioning

confidence: 99%

“…Of the 4 reported adult cats with naturally occurring primary hypothyroidism, 2 had lymphocytic thyroiditis, 1 had idiopathic atrophy, and 1 had a goitrous form of hypothyroidism associated with diffuse thyroid follicular hyperplasia of both thyroid lobes . Goitrous hypothyroidism is extremely rare in dogs, with iatrogenic, drug‐induced thyroid goiter being the most common cause . However, a subset of adult hypothyroid humans have goiter secondary to iodine deficiency, environmental goitrogens, or ineffective thyroid hormone synthesis caused by biosynthetic defect (dyshormonogenesis) …”

Section: Introductionmentioning

confidence: 99%

Spontaneous primary hypothyroidism in 7 adult cats

Peterson

Carothers²,

Gamble

et al. 2018

Veterinary Internal Medicne

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BackgroundNaturally occurring hypothyroidism in adult cats is rare, with only 4 cases reported.ObjectivesTo describe the historical, clinical, laboratory, and scintigraphic features of adult cats with spontaneous hypothyroidism.AnimalsSeven adult cats referred for suspected hypothyroidism.MethodsProspective case series. We collected data on cats’ signalment, clinical signs, results of physical examination, routine laboratory and thyroid hormone testing, and thyroid imaging (thyroid scintigraphy or ultrasound). We subsequently treated cats with levothyroxine and evaluated their response to treatment.ResultsCats ranged from 3.5 to 11 years, with no apparent breed predilection; 6/7 cats were male. Only 2/7 cats were initially tested because of signs of hypothyroidism (hair‐coat changes, lethargy, obesity); others were tested for routine thyroid monitoring or palpable thyroid nodules. Four were azotemic (serum creatinine, 2.2‐3.4 mg/dL). Six of the cats had low serum thyroxine (T4) and free T4 (fT4) concentrations, whereas all 7 cats had high thyroid‐stimulating hormone (TSH) concentrations. In 6/7 cats, thyroid scintigraphy revealed bilateral goiter with intense radionuclide uptake; imaging showed no visible thyroid tissue in the other. After levothyroxine treatment, serum concentrations of T4 and fT4 increased and TSH fell; high serum creatinine normalized in azotemic cats; and repeat imaging showed reduction in goiter size.Conclusions and Clinical ImportancePrimary hypothyroidism develops in adult cats, with a higher prevalence than previously thought. Most cats appear to develop a goitrous form of hypothyroidism associated with thyroid hyperplasia, whereas thyroid atrophy appears to be less common. With levothyroxine replacement, clinical and laboratory abnormalities improve or resolve.

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“…If follicular cell hyperplasia and hypertrophy are severe, gross enlargement (macroscopic goiter) of the thyroid gland develops 106 . Interspecies variation in the thyroid gland response to sulfonamides is pronounced, with a mild alteration in humans 117 compared to marked thyroid dysfunction in the rat 118 and dog 57,59,60,119‐123 …”

Section: Effects Of Drugs On Thyroid Functionmentioning

confidence: 99%

“…106 Interspecies variation in the thyroid gland response to sulfonamides is pronounced, with a mild alteration in humans 117 compared to marked thyroid dysfunction in the rat 118 and dog. 57,59,60,[119][120][121][122][123] Numerous prospective studies in dogs have evaluated the effects of potentiated sulfonamides on thyroid function tests. In general, the collective results indicate that drug dose and treatment duration have the largest impact, but alternative variables such as the sulfonamide moiety used and drug PO bioavailability also may play roles.…”

Section: Sulfonamidesmentioning

confidence: 99%

Influence of medications on thyroid function in dogs: An update

Bolton

Panciera

2023

Veterinary Internal Medicne

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Erroneous thyroid function test results can occur because of drugs that alter thyroid hormone physiology in one or more aspects, including synthesis, secretion, distribution, and metabolism. Research since publication of the last review in the Journal of Veterinary Internal Medicine (JVIM) 20 years ago has evaluated the effects of amiodarone, zonisamide, inhalant anesthetics, clomipramine, trilostane, and toceranib on thyroid function tests in the dog. In addition, recent work on the effects of glucocorticoids, sulfonamides, phenobarbital, and nonsteroidal anti‐inflammatory drugs will be reviewed. Awareness of these effects is necessary to avoid misdiagnosis of hypothyroidism and unnecessary treatment.

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Imaging Diagnosis—acquired Goitrous Hypothyroidism Following Treatment With Trimethoprim Sulfamethoxazole

Cited by 4 publications

References 11 publications

Hypothyroidism

Hypothyroidism

Spontaneous primary hypothyroidism in 7 adult cats

Influence of medications on thyroid function in dogs: An update

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