Imaging contribution for the diagnosis of disseminated paracoccidioidomycosis

Morais, Rafaela Queiroz de; Salomon, Marcela Frotté Bopp; Corbiceiro, Weydler Campos Hottz; Melo, Alessandro Severo Alves de; Corrêa, Diogo Goulart

doi:10.1016/j.ijid.2020.09.1482

Cited by 1 publication

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“…The most common imaging pattern of pulmonary PCM is a combination of two or more of these lesions in the same exam ( Figure 2 ). 37–39 …”

Section: Imaging Featuresmentioning

confidence: 99%

“…The most common imaging pattern of pulmonary PCM is a combination of two or more of these lesions in the same exam (Figure 2). [37][38][39] Granuloma Granulomas are the most common presentation of neuro-PCM, which is characterized by single or multiple lesions in different parts of the central nervous system, without calcifications, with perilesional edema, and mass effect. On CT, this lesion is hypodense, with irregular margins, irregular peripheral contrast enhancement of varying thickness, associated with perilesional edema.…”

Section: Imaging Featuresmentioning

confidence: 99%

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Insights into Magnetic Resonance Imaging Findings in Central Nervous System Paracoccidioidomycosis: A Comprehensive Review

Costa¹,

Hygino²,

Souza³

et al. 2023

RRTM

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Paracoccidioidomycosis (PCM) is a infection caused by the thermodimorphic fungus Paracoccidioides spp. (P. lutzii and, mainly, P. brasiliensis ). This infection predominantly affects rural male workers aged between 30 and 50 years old who deal with soil on daily activities. Clinically, the disease is classified as acute/subacute phase, which evolves rapidly, secondary to dissemination of the fungus through to the phagocytic-mononuclear system, leading to fever, weight loss, and anorexia, associated with hepatosplenomegaly and lymphadenopathy, which can be complicated with suppuration and fistulization; and chronic phase, which corresponds to 74% to 95% of symptomatic cases, with a common pulmonary involvement. Central nervous system involvement is almost always a characteristic of the chronic form. Inhalation is the most common route of primary infection, usually affecting the lungs, forming the primary complex. From the primary complex, hematogenic dissemination can occur to any organ, including the brain and spinal cord. Although PCM of the central nervous system diagnosis is usually based on histopathological analysis and the imaging features are not specific for PCM, computed tomography and magnetic resonance imaging can demonstrate evidences of granuloma, abscess, meningitis, or a combination of these lesions, contributing to a preoperative diagnosis, especially when considered in conjunction with epidemiology. In this article, we review the pathophysiology, clinical manifestations and imaging aspects of neuro-PCM.

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“…The most common imaging pattern of pulmonary PCM is a combination of two or more of these lesions in the same exam ( Figure 2 ). 37–39 …”

Section: Imaging Featuresmentioning

confidence: 99%

Section: Imaging Featuresmentioning

confidence: 99%