Imaging Characteristics of Breast Lymphoma; a Case Series

Abstract

Introduction: Breast involvement by lymphoma is rare. It can occur as a primary breast tumour or as an extranodal manifestation of the systemic disease. The imaging features of breast lymphoma (BL) arenot characteristic. Biopsy is necessary for diagnosis due to non-specific imaging features. Materials and Methods: A retrospective electronic medical chart review was conducted of patients diagnosed with lymphomaof breast that underwent diagnostic radiological procedures (including mammography, ultrasound breast, computed tomography (CT) scan and positron emission tomography (PET/CT) scan from 1 July 2018 to 31 March 2019 at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Pakistan. Results: Four patients were identified. On mammogram, the most common finding consisted of the presence of high-density masses with circumscribed or indistinct margins. On ultrasound, hypoechoic masses and indistinct diffuse infiltrative patterns were observed. PET/CT and CT were helpful in detecting extramammary sites of disease and for classifying the disease into primary or secondary BL. Conclusion: The early diagnosis of the BL is important. The radiologists should include lymphoma in the differential diagnosis when there is the absence of microcalcifications or spiculated margins on mammography and ultrasound.

Secondary breast lymphoma: A case report

“…Lymphoma is a hematologic malignancy that frequently involves the breast. Lymphoma appears as a primary tumor or as an extranodal manifestation of a secondary disease [ 4 , 7 , 13 , 17 ].…”

“…It may manifest as metastatic disease or recurrent disease. The age of presentation is 60-65 years [ [2] , [3] , [4] , [5] , 7 , 12 , 15 ].…”

“…Abnormal axillary nodes may be seen ipsilaterally in primary lymphoma and bilaterally in secondary lymphoma. Microcalcifications and mass with spiculated margins have not been reported in the literature in this type of tumors [ [2] , [3] , [4] , 7 , 9 , 10 , [13] , [14] , [15] , 17 , 18 ].…”

“…Abnormal axillary nodes are also seen. In cases with skin involvement, small superficial nodules, and skin thickening are identified due to lymphatic blockage of the tumor, resulting in retrograde edema [ [2] , [3] , [4] , 7 , 9 , 10 , [13] , [14] , [15] , [16] , [17] ].…”