Imaging Cardiac Stem Cell Transplantation Using Radionuclide Labeling
                        Techniques: Clinical Applications and Future Directions

Ležaič, Luka; Haddad, François; Vrtovec, Bojan; Wu, Joseph C.

doi:10.14797/mdcj-9-4-218

Cited by 5 publications

(4 citation statements)

References 26 publications

(22 reference statements)

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“…Nuclear medicine imaging technology refers to the use of radionuclide as tracers, which is suitable for functional and metabolic imaging. The most widely used radionuclide tracers include 99m Tc, 18 F-FDG, 125 I, etc., but these radionuclide tracers have certain radioactive contamination and toxicity (Lezaic et al, 2013;Skelton et al, 2015;deKemp et al, 2016). The technology need two devices, single electron emission computed tomography (SPECT) and positron emission tomography (PET), both of which have high sensitivity (Katsikis and Koutelou, 2014).…”

Section: Cell Tracingmentioning

confidence: 99%

The Current Dilemma and Breakthrough of Stem Cell Therapy in Ischemic Heart Disease

Liu

Han

Liang

et al. 2021

Front. Cell Dev. Biol.

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Ischemic heart disease (IHD) is the leading cause of mortality worldwide. Stem cell transplantation has become a promising approach for the treatment of IHD in recent decades. It is generally recognized that preclinical cell-based therapy is effective and have yielded encouraging results, which involves preventing or reducing myocardial cell death, inhibiting scar formation, promoting angiogenesis, and improving cardiac function. However, clinical studies have not yet achieved a desired outcome, even multiple clinical studies showing paradoxical results. Besides, many fundamental puzzles remain to be resolved, for example, what is the optimal delivery timing and approach? Additionally, limited cell engraftment and survival, challenging cell fate monitoring, and not fully understood functional mechanisms are defined hurdles to clinical translation. Here we review some of the current dilemmas in stem cell-based therapy for IHD, along with our efforts and opinions on these key issues.

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Section: Cell Tracingmentioning

confidence: 99%

The Current Dilemma and Breakthrough of Stem Cell Therapy in Ischemic Heart Disease

Liu

Han

Liang

et al. 2021

Front. Cell Dev. Biol.

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“…Intracoronary infusion of unselected BMMNC has low retention rates of stem cells in comparison to other techniques such as selected CD34+ or mesenchymal stem cells infusion. This factor decreases the chance of cardiomyogenic differentiation in this technique, as well (23). Thus, it may be considered in critically ill patients, to benefit from reparative effect of BMMNCs injection as a rescue treatment, as in two of inotrope dependent patients in this study.…”

Section: Discussionmentioning

confidence: 82%

A Study of Intracoronary Injection of Hematopoietic Stem Cells in Pediatric Dilated Cardiomyopathy: Is It an Applicable Solution for Critically Ill Patients?

et al. 2019

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Background: Benefits of stem cell therapy on remodelling and cardiac function have been described in adults with dilated cardiomyopathy and acute myocardial infarction. Objectives: We investigated the effect of this treatment modality amongst children with severe dilated cardiomyopathy. Methods: Intracoronary injection of autologous bone marrow mononuclear stem cells was performed in our centers for 8 severely ill children during 2015-2016. The mean age of the patients was 10.1 years (5 girls, 3 boys). They were followed by longitudinal speckle tracking echocardiography (STE) and conventional echocardiography for 6 months. Results: Heart functional class improved in 62% of patients. M-mode echocardiography showed significant improvement in ejection fraction (mean 24.8 ± 8.3 vs. 37.4 ± 10.5) and in STE, the mean global longitudinal strain improved (GLS:-2.8 ± 1.9 vs.-5.2 ± 3.9). None of the patients had serious complications. Conclusions: Intracoronary injection of autologous mononuclear stem cells might improve the ventricular function and cardiac remodelling in pediatric patients with dilated cardiomyopathy and could be considered in critically ill patients.

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“…The main goal of stem cell therapy in various studies is myocardial muscle regeneration and revascularization which is expected to improve cardiac contractility and bioelectrical conduction without serious side effects. (Lezaic, et al 2013;Van der Spoel, et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Increase Migration of Peripheral Blood Derived Endothelial Progenitor Cells of Stable Coronary Artery Disease Patient With Angiotensin Converting Enzyme Inhibitors

Achmad,

Oktaviano,

Soemantri

2023

JSCRTE

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This research is based on refractory angina pectoris, which remains a problem despite advances in coronary heart disease treatment. Stem cell therapy is still in preclinical research stages to address refractory angina. Endothelial progenitor cells (EPCs) aid in improving endothelium and the growth of new blood vessels. Heart medication has shown to enhance both the quantity and function of EPCs in patients at cardiovascular risk or with heart disease. Previous studies reported that ACE inhibitors (ACEI) have a positive effect on EPCs. Thus, this study analyzes the impact of three different ACE inhibitors on EPC migration in laboratory conditions. Its aim is to ascertain the increase in EPC migration in stable coronary heart disease patients after ACEI administration. The research methodology involves an experimental design with a control group and post-treatment assessment only. Mononuclear cells are isolated from stable coronary heart disease patients' peripheral blood and incubated for 3 days. The EPCs are then divided into captopril, ramipril, lisinopril, and a control group, observed for 48 hours. EPC migration is assessed by counting the cells moving from the upper chamber to the membrane facing the lower chamber using a transwell migration assay after 20 hours, observed with a light microscope and Giemsa staining. Data analysis via ANOVA statistical tests indicates increased EPC migration in the captopril, ramipril, and lisinopril groups compared to the control. Captopril shows the highest effect among the groups, while no significant difference is observed between captopril and lisinopril, as well as between ramipril and lisinopril.

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Imaging Cardiac Stem Cell Transplantation Using Radionuclide Labeling Techniques: Clinical Applications and Future Directions

Cited by 5 publications

References 26 publications

The Current Dilemma and Breakthrough of Stem Cell Therapy in Ischemic Heart Disease

The Current Dilemma and Breakthrough of Stem Cell Therapy in Ischemic Heart Disease

A Study of Intracoronary Injection of Hematopoietic Stem Cells in Pediatric Dilated Cardiomyopathy: Is It an Applicable Solution for Critically Ill Patients?

Increase Migration of Peripheral Blood Derived Endothelial Progenitor Cells of Stable Coronary Artery Disease Patient With Angiotensin Converting Enzyme Inhibitors

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