Imaging Brain Fatty Acid Amide Hydrolase in Untreated Patients With Psychosis

Watts, Jeremy J.; Jacobson, Maya R.; Lalang, Nittha; Boileau, Isabelle; Tyndale, Rachel F.; Kiang, Michael; Ross, Ruth A.; Houle, Sylvain; Wilson, Alan A.; Rusjan, Pablo; Mizrahi, Romina

doi:10.1016/j.biopsych.2020.03.003

Cited by 22 publications

(9 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, this is a secondary analysis of a previous published case–control study (Da Silva et al, 2019; Hafizi et al, 2017; Jacobson et al, 2021; Watts et al, 2020) and thus we cannot infer causation. While cannabis use is associated with higher calorie intake (Rodondi et al, 2006; Smit & Crespo, 2001) and could also be associated with a poorer diet quality and increase alcohol consumption (Smit & Crespo, 2001), we did not collect detailed dietary or physical activity habits of the participants in the study and blood was not withdrawn fasting.…”

Section: Discussionmentioning

confidence: 99%

“…Blood samples were collected from NCU and CU prior to the injection of PET radiotracers scan for previous studies reported elsewhere (Da Silva et al, 2019; Hafizi et al, 2017; Jacobson et al, 2021; Watts et al, 2020). Whole‐blood samples were centrifuged at 3000× g for 5 min at 4°C to isolate serum.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, we conducted a secondary analysis of a clinical study (Da Silva et al, 2019; Hafizi et al, 2017; Watts et al, 2020) to evaluate whether cannabis use could alter fatty acid metabolism, their bioactive metabolites, and consequently the immune response in cannabis users (CU) compared to non‐cannabis users (NCU) following overnight abstinence.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long‐term cannabis users: A secondary analysis of a case–control study

Cisbani

Koppel

Metherel

et al. 2022

Lipids

Self Cite

View full text Add to dashboard Cite

Cannabis is now legal in many countries and while numerous studies have reported on its impact on cognition and appetite regulation, none have examined fatty acid metabolism in young cannabis users. We conducted an exploratory analysis to evaluate cannabis impact on fatty acid metabolism in cannabis users (n = 21) and non‐cannabis users (n = 16). Serum levels of some saturated and monounsaturated fatty acids, including palmitic, palmitoleic, and oleic acids were higher in cannabis users compared to nonusers. As palmitic acid can be derived from diet or lipogenesis from sugars, we evaluated lipogenesis using a de novo lipogenesis index (palmitate/linoleic acid) and carbon‐specific isotope analysis, which allows for the determination of fatty acid 13C signature. The significantly higher de novo lipogenesis index in the cannabis users group along with a more enriched 13C signature of palmitic acid suggested an increase in lipogenesis. In addition, while serum glucose concentration did not differ between groups, pyruvate and lactate were lower in the cannabis user group, with pyruvate negatively correlating with palmitic acid. Furthermore, the endocannabinoid 2‐arachidonoylglycerol was elevated in cannabis users and could contribute to lipogenesis by activating the cannabinoid receptor 1. Because palmitic acid has been suggested to increase inflammation, we measured peripheral cytokines and observed no changes in inflammatory cytokines. Finally, an anti‐inflammatory metabolite of palmitic acid, palmitoylethanolamide was elevated in cannabis users. Our results suggest that lipogenic activity is increased in cannabis users; however, future studies, including prospective studies that control dietary intake are required.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long‐term cannabis users: A secondary analysis of a case–control study

Cisbani

Koppel

Metherel

et al. 2022

Lipids

Self Cite

View full text Add to dashboard Cite

show abstract

“…No se halló suficiente significación esta-dística con respecto al polimorfismo rs324420. Watts et al (2020) encontraron recientemente que niveles más bajos de FAAH se asociaron con síntomas psicóticos más graves. Estos resultados fueron independientes de la exposición al cannabis.…”

Section: Faahunclassified

El gen del receptor cannabinoide tipo 2 se asocia con la comorbilidad entre esquizofrenia y dependencia de cannabis y el gen de la enzima amidohidrolasa de ácidos grasos se asocia con la dependencia de cannabis en población española

Horcajadas

Piriz²,

González

et al. 2021

Adicciones

View full text Add to dashboard Cite

El gen del receptor cannabinoide tipo 2 se asocia con la comorbilidad entre esquizofrenia y dependencia de cannabis y el gen de la enzima amidohidrolasa de ácidos grasos se asocia con la dependencia de cannabis en población española Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population

show abstract

“…From imaging studies to pharmacological experimental reports, current findings suggest that the enzymes involved in the synthesis and degradation of endocannabinoids play a modulatory role in schizophrenia [ 131 , 132 ]. For example, patients with the first episode of psychosis showed an increase in the expression of FAAH and MAGL, whereas a decrease in the levels of NAPE and DAGL was found as compared to healthy controls [ 133 ].…”

Section: The Modulatory Role Of the Endocannabinoid System In Mental ...mentioning

confidence: 99%

The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health

Amatriain-Fernández

Budde

Gronwald

et al. 2021

View full text Add to dashboard Cite

: According to the World Health Organization (WHO), 47 million of people display mental health disorders Worldwide. In addition, epidemiological studies have shown that the extension of life expectancy and the increase in aged population will significantly impact in the prevalence of several mental impairments. Although there are strategies for preventing and alleviate mental illnesses such as pharmacological and psychological approaches, limited results have been observed. Thus, the search for new therapeutics for managing psychiatric disorders has explored multiple roads. In recent years, it has been demonstrated that physical activity and exercise promote health benefits. On the other hand, among the neurobiological systems that participate in the genesis and development of mental disruptions, the endocannabinoid system has been suggested as an active player. Supporting this hypothesis, data suggest that the elements comprising the endocannabinoid system, such as the CB1/CB2 cannabinoid receptors, endogenous ligands (N-arachidonoylethanolamine [anandamide, AEA] and 2-arachidonoylglycerol [2- AG]), transporters and the enzymes involved in the biosynthesis and degradation of the AEA and 2-AG, modulate mental diseases. In this review, we discuss that the endocannabinoid system might be considered as a modulator for the positive outcomes of exercise in the management of mental disorders. Clinically, this promising field might be exploited by targeting the elements of the endocannabinoid system aimed to increase the exercise benefits applied to patients with mental illnesses.

show abstract

Imaging Brain Fatty Acid Amide Hydrolase in Untreated Patients With Psychosis

Cited by 22 publications

References 53 publications

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long‐term cannabis users: A secondary analysis of a case–control study

Serum lipid analysis and isotopic enrichment is suggestive of greater lipogenesis in young long‐term cannabis users: A secondary analysis of a case–control study

El gen del receptor cannabinoide tipo 2 se asocia con la comorbilidad entre esquizofrenia y dependencia de cannabis y el gen de la enzima amidohidrolasa de ácidos grasos se asocia con la dependencia de cannabis en población española

The Endocannabinoid System as Modulator of Exercise Benefits in Mental Health

Contact Info

Product

Resources

About