Imaging Assessment of Cardiovascular Disease in Systemic Lupus Erythematosus

Croca, Sara; Rahman, Anisur

doi:10.1155/2012/694143

Cited by 20 publications

(16 citation statements)

References 57 publications

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“…Patients with SLE have an excess cardiovascular risk compared with general population, leading to increased cardiovascular morbidity and mortality. Although the precise explanation for this is yet to be established, it seems to be associated with the presence of an accelerated atherosclerotic process, arising from the combination of traditional and lupus-specific risk factors [1]. The CVD risk among SLE patients compared with the general population is at least doubled.…”

Section: Discussionmentioning

confidence: 99%

“…Development and establishment of new stratification tools to efficiently identify patients at increased cardiovascular risk are essential. With advances in imaging techniques, the ultimate goal of cardiovascular assessment will shift from assessing symptomatic patients to diagnosing asymptomatic early CVD which will hopefully help prevent its progression [1].…”

Section: Discussionmentioning

confidence: 99%

“…Systemic lupus erythematosus (SLE) is a chronic and multisystemic autoimmune disorder [1,2]. It may result from disturbed tolerance to self antigens and development of auto-antibodies leading to the formation of immune complexes.…”

Section: Introductionmentioning

confidence: 99%

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Intima-media thickness in secondary anti-phospholipid syndrome patients: Impact of disease activity

Raafat

Fawzy

Fishawy

2015

The Egyptian Rheumatologist

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Aim of the work: To assess the carotid intima-media thickness (IMT) and plaque formation in systemic lupus erythematosus (SLE) patients with and without antiphospholipid syndrome (APS) by doppler ultrasonography and to correlate it with the clinical features, disease activity and damage.Patients and methods: Thirty-six female SLE patients with secondary APS and another 36 without were included. Thirty-six matching healthy volunteers were included as control. In patients, the disease activity and damage were assessed using the SLE Disease Activity Index (SLEDAI) and Systemic Lupus International Collaborating Clinics (SLICC) index, respectively. Doppler ultrasound was carried out for patients and control and the IMT was measured.Results: The demographic and clinical characteristics of patients are presented. The disease activity was significantly higher in SLE patients with APS (19.7 ± 7.9) compared to SLE only patients (15.1 ± 9.2) (p = 0.03). The low density lipoprotein (LDL) was significantly increased in APS patients (p = 0.04). The IMT was comparable between both groups (0.83 ± 0.15 mm) vs (0.86 ± 0.2 mm) (p = 0.55) and both were significantly increased compared to the control (0.61 ± 0.11 mm) (p < 0.0001). The dyslipidemia present in the patients showed a significant difference in the measured lipid profile parameters (p < 0.0001). The IMT significantly correlated with the SLEDAI in both groups (p < 0.002 and <0.001 respectively).Conclusion: The increased IMT as a marker of atherosclerosis is confirmed in SLE patients with no obvious difference in those with secondary APS. The link between the increased IMT and disease activity favors the role of disease-specific potential risk factors, in addition to the traditional conventional ones, in the development of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Intima-media thickness in secondary anti-phospholipid syndrome patients: Impact of disease activity

Raafat

Fawzy

Fishawy

2015

The Egyptian Rheumatologist

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“…It should be noted that diagnostic imaging revealed subclinical atherosclerosis in 30-52% of SLE patients [24,25,27,28].…”

Section: Introductionmentioning

confidence: 97%

“…[14]. Vascular disease in SLE patients can occur due to a combination of diferent pathological processes, for example, atherosclerosis, cloting disorders, and systemic vasculitis associated with vascular wall injury (especially endothelial dysfunction), caused by an autoimmune process [24,28].…”

Section: Introductionmentioning

confidence: 99%

Accelerated Atherosclerosis in Patients with Systemic Lupus Erythematosus and the Role of Selected Adipocytokines in This Process

Hrycek¹,

Banasiewicz-Szkróbka²,

AleksanderŻurakowski³

et al. 2017

Lupus

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Systemic lupus erythematosus (SLE) can afect various systems and organs. The most severe forms of the disease afect the kidneys, the central nervous system, and the heart. Cardiac and cardiovascular system diseases are inter alia caused by atherosclerosis, vasculitis, and thromboembolic events. Patients with SLE are at a higher risk of developing accelerated atherosclerosis. This process in SLE patients cannot be explained solely based on classical risk factors. Recently, some adipocytokines/adipokines have been indicated in the development of atherosclerosis, inlammation, and immune processes. It has also been postulated that adipokines might regulate the immune response and hence the atherogenic process. In this work, the factors contributing to accelerated atherosclerosis in SLE patients with special respect to vasculitis/vascular injury are presented, and selected adipocytokines, that is leptin, resistin, and adiponectin, with their relation to atherosclerosis and SLE, are under discussion.

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Sex-Specific Cardiovascular Comorbidities with Associations in Dermatologic and Rheumatic Disorders

Kerkhof¹,

Хамаганова

2018

Advances in Experimental Medicine and Biology

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Cardiology, dermatology, and rheumatology form a fascinating triad. Many skin and joint disorders are associated with cardiovascular comorbidities because they share etiologic elements. Female predominance is often remarkable and likely related to autoimmune pathology. Although studies have shown that X-encoded genes may be involved in the differences in immunity between males and females, other studies have also shown that sex chromosomes are irrelevant and that estrogens and androgens are responsible for the differences. The elevated immune activity in females provides a beneficial position in coping with a pathogenic stimulus but may also enhance their susceptibility to autoimmunity. The complexity of the immune system and its role as a defensive force against infection requires an armamentarium to precisely identify and selectively control inflammatory processes or cells which promote atherosclerosis. On the other hand, the inflammation in skin diseases seems to be an active source of diverse proinflammatory cytokines and chemokines which can predispose to cardiovascular comorbidities. Also, it has been shown that comorbidity disproportionately accelerates risk in women.The skin offers a readily available window to facilitate detection of risk factors or even to assist the diagnostic process regarding a variety of disorders, including those with cardiovascular involvement. Current imaging techniques provide exquisite capabilities for diagnosing and possibly even counteracting atherosclerotic plaque formation, before serious cardiovascular events occur. Combining imaging approaches (such as videocapillaroscopy, intravascular ultrasound, and FDG positron emission tomography) with insights based on immunology will likely accelerate advances in this area.We review major dermatologic manifestations and rheumatologic disorders which are associated with cardiac and vascular abnormalities. In particular we discuss sex-specific aspects concerning incidence and severity of cardiovascular disease associated with systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, atopic dermatitis, and hidradenitis suppurativa.

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Imaging Assessment of Cardiovascular Disease in Systemic Lupus Erythematosus

Cited by 20 publications

References 57 publications

Intima-media thickness in secondary anti-phospholipid syndrome patients: Impact of disease activity

Intima-media thickness in secondary anti-phospholipid syndrome patients: Impact of disease activity

Accelerated Atherosclerosis in Patients with Systemic Lupus Erythematosus and the Role of Selected Adipocytokines in This Process

Sex-Specific Cardiovascular Comorbidities with Associations in Dermatologic and Rheumatic Disorders

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