Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy

Cui, Ying; Zhu, Ying; Wang, Jay C.; Lu, Yifan; Zeng, Rebecca; Katz, Raviv; Wu, David M.; Vavvas, Demetrios G.; Husain, Deeba; Miller, Joan W.; Kim, Leo A.

doi:10.1167/tvst.8.6.18

Cited by 53 publications

(33 citation statements)

References 26 publications

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“…Because of the large dimension of the scans, the time necessary for acquisition, and the automated fusion operated by the instrument, OCTA montage images are susceptible to all these types of artifacts. Patients with higher-severity DR eyes with NV, epiretinal membrane, diabetic macular edema, and pigment epithelium detachment may be at particular risk for poor-quality imaging [ 26 ].…”

Section: Technical Solutions To Achieve Wf-octamentioning

confidence: 99%

Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

Amato

Nadin

Borghesan

et al. 2020

Journal of Diabetes Research

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Purpose. To summarize the role of widefield optical coherence tomography angiography (WF-OCTA) in diabetic retinopathy (DR), extending from the acquisition strategies to the main clinical findings. Methods. A PubMed-based search was carried out using the terms “Diabetic retinopathy”, “optical coherence tomography angiography”, “widefield imaging”, and “ultra-widefield imaging”. All studies published in English up to August 2020 were reviewed. Results. WF-OCTA can be obtained with different approaches, offering advantages over traditional imaging in the study of nonperfusion areas (NPAs) and neovascularization (NV). Quantitative estimates and topographic distribution of NPA and NV are useful for treatment monitoring and artificial intelligence-based approaches. Curvature, segmentation, and motion artifacts should be assessed when using WF-OCTA. Conclusions. WF-OCTA harbors interesting potential in DR because of its noninvasiveness and capability of objective metrics of retinal vasculature. Further studies will facilitate the migration from traditional imaging to WF-OCTA in both the research and clinical practice fields.

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Section: Technical Solutions To Achieve Wf-octamentioning

confidence: 99%

Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

Amato

Nadin

Borghesan

et al. 2020

Journal of Diabetes Research

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“…All examinations were performed by one experienced researcher, and each OCTA image was graded using the motion artifact score (MAS) (score 1–6). 6 A higher MAS reflected more artifacts and lower image quality. Only the images with a MAS of <2 were used for analysis.…”

Section: Methodsmentioning

confidence: 98%

A Comparative Study of Macular and Choroidal Thickness and Blood-Flow Parameters in Patients with Intermediate and Simple Juvenile Moderate Myopia

Lin¹,

Yang

Lin³

et al. 2021

IJGM

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Objective This study aimed to compare the macular and choroidal thicknesses and blood-flow parameters of patients with intermediate and simple juvenile moderate myopia in order to provide a greater understanding of the pathogenesis of myopia and a basis for its prevention. Methods Participants were selected from patients under the age of 18 with moderate myopia who were treated in our ophthalmic clinic between June and December 2019. Seventy-five right eyes were selected from participants with a mean spherical equivalent ranging from −6.0 to −3.0 D. These samples were divided into two groups based on eye axial length (AL). The thicknesses of the macula and choroid, the area of the foveal avascular zone (FAZ), and the blood flow density of the macular capillaries were measured, intergroup comparison was conducted. Results The average area of the FAZ was larger in the intermediate group than in the simple group. PERIM in the upper half was lower in the intermediate group than in the simple group, and the blood-flow density in the lower half of the macular area was higher in the simple group than in the intermediate group. The blood-flow density within 1 mm of the fovea centralis and the downward blood-flow density were higher in the intermediate group than in the simple group. The thicknesses of the lower part of the FAZ, the choroid of the fovea centralis, and the choroid under the retina were all larger in the intermediate group than in the simple group. Conclusion The area of the FAZ in patients with intermediate juvenile moderate myopia is larger than that in patients with simple myopia; the choroid in the fovea of macula compensatorily increases, and blood flow density also increases; the thickness of the choroid under the retina increases with myopia.

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“…The accuracy of segmentation algorithms in the identification of retinal layers, especially in eyes with pathological abnormalities, imposes the limitation in OCTA data interpretation. The occurrence of segmentation error was 11% in the non-proliferative DR category and increased to 50% in the proliferative DR category [179]. Furthermore, high rates of segmentation error, particularly in eyes with diabetic macular edema, that may affect vascular density measurements, were reported [180].…”

Section: Limitations Of Optical Coherence Tomography Angiographymentioning

confidence: 98%

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

Chua

Sim

Tan

et al. 2020

JCM

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Diabetic retinopathy (DR) is a common complication of diabetes mellitus that disrupts the retinal microvasculature and is a leading cause of vision loss globally. Recently, optical coherence tomography angiography (OCTA) has been developed to image the retinal microvasculature, by generating 3-dimensional images based on the motion contrast of circulating blood cells. OCTA offers numerous benefits over traditional fluorescein angiography in visualizing the retinal vasculature in that it is non-invasive and safer; while its depth-resolved ability makes it possible to visualize the finer capillaries of the retinal capillary plexuses and choriocapillaris. High-quality OCTA images have also enabled the visualization of features associated with DR, including microaneurysms and neovascularization and the quantification of alterations in retinal capillary and choriocapillaris, thereby suggesting a promising role for OCTA as an objective technology for accurate DR classification. Of interest is the potential of OCTA to examine the effect of DR on individual retinal layers, and to detect DR even before it is clinically detectable on fundus examination. We will focus the review on the clinical applicability of OCTA derived quantitative metrics that appear to be clinically relevant to the diagnosis, classification, and management of patients with diabetes or DR. Future studies with longitudinal design of multiethnic multicenter populations, as well as the inclusion of pertinent systemic information that may affect vascular changes, will improve our understanding on the benefit of OCTA biomarkers in the detection and progression of DR.

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Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy

Cited by 53 publications

References 26 publications

Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

Widefield Optical Coherence Tomography Angiography in Diabetic Retinopathy

A Comparative Study of Macular and Choroidal Thickness and Blood-Flow Parameters in Patients with Intermediate and Simple Juvenile Moderate Myopia

Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

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