Imaging articular cartilage under compression—cartilage elastography

Hardy, Peter; Ridler, Anne C.; Chiarot, Cameron B.; Plewes, Don B.; Henkelman, R. Mark

doi:10.1002/mrm.20439

Cited by 34 publications

(29 citation statements)

References 31 publications

(34 reference statements)

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“…A large number of MRI- and ultrasound-based techniques are available to map displacements and strain at high resolution, which are then coupled to material models to estimate stress [122] or material properties [123–126], most often classified as elastography [127]. Because the material properties of cartilage change in OA [8], controlled magnitudes of ex vivo or in vivo mechanical loading would likely result in aberrant deformation for progressively diseased tissue, suggesting that displacement or strain alone may be a sufficiently unique functional measure.…”

Section: Functional Imaging Of Cartilage Mechanicsmentioning

confidence: 99%

Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics

Neu

2014

Osteoarthritis and Cartilage

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Functional imaging refers broadly to the visualization of organ or tissue physiology using medical image modalities. In load-bearing tissues of the body, including articular cartilage lining the bony ends of joints, changes in strain, stress, and material properties occur in osteoarthritis (OA), providing an opportunity to probe tissue function through the progression of the disease. Here, biomechanical measures in cartilage and related joint tissues are discussed as key imaging biomarkers in the evaluation of OA. Emphasis will be placed on the a) potential of radiography, ultrasound, and magnetic resonance imaging to assess early tissue pathomechanics in OA, b) relative utility of kinematic, structural, morphological, and biomechanical measures as functional imaging biomarkers, and c) improved diagnostic specificity through the combination of multiple imaging biomarkers with unique contrasts, including elastography and quantitative assessments of tissue biochemistry. In comparison to other modalities, magnetic resonance imaging provides an extensive range of functional measures at the tissue level, with conventional and emerging techniques available to potentially to assess the spectrum of preclinical to advance OA.

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Section: Functional Imaging Of Cartilage Mechanicsmentioning

confidence: 99%

Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics

Neu

2014

Osteoarthritis and Cartilage

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“…Cartilage deformation by tag registration imposes lines of interest onto cartilage and tracks these during the cyclic compression of cartilage [67,72], but requires interpolation to determine depthdependent responses to load. In terms of pixel-by-pixel mechanical characterization, displacement-sensitive stimulated-echo acquisition mode (STEAM) has measured deformations and strains in articular cartilage [73]. MR elastography [74] can determine the shear properties of articular cartilage [25] and measure changes that occur with enzymatic degradation [24].…”

Section: Magnetic Resonance Imaging To Quantify Mechanical Changes Wimentioning

confidence: 99%

“…STEAM is constrained by long imaging times and low resolution, which becomes a major limitation with thinner tissues such as articular cartilage. Propagating high-frequency shear [24,25] or compression [73] waves indirectly to tissue within intact joints for MR elastography and STEAM, respectively, is technically difficult and requires additional equipment (i.e. highfrequency actuators).…”

Section: Magnetic Resonance Imaging To Quantify Mechanical Changes Wimentioning

confidence: 99%

Probing articular cartilage damage and disease by quantitative magnetic resonance imaging

Chan

Neu

2013

J. R. Soc. Interface.

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Osteoarthritis (OA) is a debilitating disease that reflects a complex interplay of biochemical, biomechanical, metabolic and genetic factors, which are often triggered by injury, and mediated by inflammation, catabolic cytokines and enzymes. An unmet clinical need is the lack of reliable methods that are able to probe the pathogenesis of early OA when disease-rectifying therapies may be most effective. Non-invasive quantitative magnetic resonance imaging (qMRI) techniques have shown potential for characterizing the structural, biochemical and mechanical changes that occur with cartilage degeneration. In this paper, we review the background in articular cartilage and OA as it pertains to conventional MRI and qMRI techniques. We then discuss how conventional MRI and qMRI techniques are used in clinical and research environments to evaluate biochemical and mechanical changes associated with degeneration. Some qMRI techniques allow for the use of relaxometry values as indirect biomarkers for cartilage components. Direct characterization of mechanical behaviour of cartilage is possible via other specialized qMRI techniques. The combination of these qMRI techniques has the potential to fully characterize the biochemical and biomechanical states that represent the initial changes associated with cartilage degeneration. Additionally, knowledge of in vivo cartilage biochemistry and mechanical behaviour in healthy subjects and across a spectrum of osteoarthritic patients could lead to improvements in the detection, management and treatment of OA.

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“…While there is a strong influence of hydrodynamic effects during fast cyclic compression, in the static case we find a more balanced biomechanical system. Many authors report that MRI visualization changes under pressure (10,(31)(32)(33)(34)(35)(36)(37)(38). It is evident that collagen network structure is influenced by load.…”

Section: Influence Of Load On the Mri Visualization Of Joint Cartilagementioning

confidence: 99%

MRI assessment of cartilage ultrastructure

Gründer¹

2006

NMR in Biomedicine

121

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In T 2 -weighted MRI images joint cartilage can appear laminated. The multilaminar appearance is visualized as zones of different intensity. This appearance is based on the dipolar interaction of water molecules within cartilage zones of different collageneous network structures. Therefore, the MR visualization of zones of anisotropic arrangement of the collagen fibers depends upon their orientation to the static magnetic field (magic-angle effect). The aim of this article is to demonstrate the potential of high-resolution MRI for characterizing cartilage network structuring and biomechanical properties. Information equivalent to that from polarization light microscopy can be derived noninvasively. Based on NMR microscopic (mMRI) data, potential new possibilities of MRI for quantitative assessment of collagen structuring and intracartilagenous load distribution are presented. These methods use MR intensity angle dependence and load influence on cartilage visualization. Alternatively to the determination of mechanical parameters from cartilage deformation, it is demonstrated that stress distribution and biomechanical properties can be derived in principle from the local intensity variation of anisotropic fiber orientation zones. The limitations with respect to a clinical application of the proposed methods are discussed.

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Imaging articular cartilage under compression—cartilage elastography

Cited by 34 publications

References 31 publications

Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics

Functional imaging in OA: role of imaging in the evaluation of tissue biomechanics

Probing articular cartilage damage and disease by quantitative magnetic resonance imaging

MRI assessment of cartilage ultrastructure

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